UCSF

Glutamate Receptor Ionotropic, AMPA 4, Mouse (25 Compounds)

Swissprot:
GRIA4_MOUSE
Stitch:
GRIA4_MOUSE
UniProt:
Q9Z2W8
ChEMBL:
CHEMBL3615
Reactome:
REACT_252788
REACT_253367
REACT_258217
PDB:
Gria4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 25 5 4 3
Binding ≤ 1μM 16 5 4 3
Functional ≤ 10μM 7 1 1 0

Reactome Network (3)

Reactome ID Description Species
REACT_252788 Activation of AMPA receptors Mus musculus
REACT_253367 Trafficking of GluR2-containing AMPA receptors Mus musculus
REACT_258217 Unblocking of NMDA receptor, glutamate binding and activation Mus musculus
Uniprot Swissprot Chembl Description Number Shared
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 31
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 31

Trafficking of GluR2-containing AMPA receptors

Uniprot Swissprot Chembl Description Number Shared
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 31
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 31

Unblocking of NMDA receptor, glutamate binding and activation

Uniprot Swissprot Chembl Description Number Shared
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 31
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 31
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 122 18 13 13
GRIA4_RAT P19493 CHEMBL3505 Glutamate Receptor Ionotropic, AMPA 4, Rat 657 37 21 25
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 567 31 19 19
GRIA2_MOUSE P23819 CHEMBL3205 Glutamate Receptor Ionotropic, AMPA 2, Mouse 25 5 4 3
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 25 5 4 3

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
GRIA4-1-E Glutamate Receptor Ionotropic, AMPA 4 (cluster #1 Of 5), Eukaryotic 623 17 7 6
GRIA4-2-E Glutamate Receptor Ionotropic, AMPA 4 (cluster #2 Of 5), Eukaryotic 13 4 1 1
GRIA4-3-E Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic 51 4 5 4
GRIA4-4-E Glutamate Receptor Ionotropic, AMPA 4 (cluster #4 Of 5), Eukaryotic 58 20 10 20
GRIA4-5-E Glutamate Receptor Ionotropic, AMPA 4 (cluster #5 Of 5), Eukaryotic 23 1 3 1
Uniprot Swissprot Chembl Description Number Shared
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 31
GRIA2_MOUSE P23819 CHEMBL3205 Glutamate Receptor Ionotropic, AMPA 2, Mouse 31
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 31
GRIK1_HUMAN P39086 CHEMBL1918 Glutamate Receptor Ionotropic Kainate 1, Human 9
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 8
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 8
GRIA2_RAT P19491 CHEMBL3503 Glutamate Receptor Ionotropic, AMPA 2, Rat 7
GRIA3_HUMAN P42263 CHEMBL3595 Glutamate Receptor Ionotropic, AMPA 3, Human 7
GRIA3_RAT P19492 CHEMBL3504 Glutamate Receptor Ionotropic, AMPA 3, Rat 7
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 7
GRIA4_RAT P19493 CHEMBL3505 Glutamate Receptor Ionotropic, AMPA 4, Rat 7
GRIK5_HUMAN Q16478 CHEMBL2675 Glutamate Receptor Ionotropic Kainate 5, Human 7
GRIA1_RAT P19490 CHEMBL3753 Glutamate Receptor Ionotropic, AMPA 1, Rat 6
GRIK2_HUMAN Q13002 CHEMBL3683 Glutamate Receptor Ionotropic Kainate 2, Human 6
GRIK3_HUMAN Q13003 CHEMBL3684 Glutamate Receptor Ionotropic Kainate 3, Human 6
GRIK4_HUMAN Q16099 CHEMBL2829 Glutamate Receptor Ionotropic Kainate 4, Human 6
GRIK1_RAT P22756 CHEMBL2919 Glutamate Receptor Ionotropic Kainate 1, Rat 4
GRIK2_RAT P42260 CHEMBL3607 Glutamate Receptor Ionotropic Kainate 2, Rat 4
GRIK3_RAT P42264 CHEMBL3744 Glutamate Receptor Ionotropic Kainate 3, Rat 4
GRIK4_RAT Q01812 CHEMBL3044 Glutamate Receptor Ionotropic Kainate 4, Rat 4
GRIK5_RAT Q63273 CHEMBL4041 Glutamate Receptor Ionotropic Kainate 5, Rat 4
GRM1_MOUSE P97772 CHEMBL2892 Metabotropic Glutamate Receptor 1, Mouse 4
GRM3_MOUSE Q9QYS2 CHEMBL3824 Metabotropic Glutamate Receptor 3, Mouse 4
GRM7_MOUSE Q68ED2 CHEMBL3966 Metabotropic Glutamate Receptor 7, Mouse 4
GRM8_MOUSE P47743 CHEMBL4626 Metabotropic Glutamate Receptor 8, Mouse 4
Q80T35_MOUSE Q80T35 CHEMBL3033 Metabotropic Glutamate Receptor 6, Mouse 4
Q80T43_MOUSE Q80T43 CHEMBL3779 Metabotropic Glutamate Receptor 2, Mouse 4
Q80T47_MOUSE Q80T47 CHEMBL2832 Metabotropic Glutamate Receptor 5, Mouse 4
NMDE3_RAT Q00961 CHEMBL401 Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat 3
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 2
Z50594 Z50594 CHEMBL375 Mus Musculus 2
FOLH1_HUMAN Q04609 CHEMBL1892 Glutamate Carboxypeptidase II, Human 1
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 1
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 1
GRM5_HUMAN P41594 CHEMBL3227 Metabotropic Glutamate Receptor 5, Human 1
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 1
XCT_HUMAN Q9UPY5 CHEMBL1075149 Cystine/glutamate Transporter, Human 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1