ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (135)
Reactome (2)
Related By:
Pathway (4)
Organism (1)
Gene (4)
Org. Clust. (2)
ChEMBL (61)
Rings (8)

Glutamate Receptor Ionotropic Kainate 1, Human (135 Compounds)

Swissprot:: GRIK1_HUMAN
Stitch:: GRIK1_HUMAN
UniProt:: P39086
ChEMBL:: CHEMBL1918
Reactome:: REACT_21346; REACT_21343
PDB:: 2ZNS (DOCK); 2ZNT (DOCK); 2ZNU (DOCK); 3FUZ (DOCK); 3FV1 (DOCK); 3FV2 (DOCK); 3FVG (DOCK); 3FVK (DOCK); 3FVN (DOCK); 3FVO (DOCK); GRIK1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	135	26	10	8
Binding ≤ 1μM	70	6	7	6
Functional ≤ 10μM	14	3	0	0

Reactome ID	Description	Species
REACT_21346	Activation of Ca-permeable Kainate Receptor	Homo sapiens
REACT_21343	Activation of Na-permeable Kainate Receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	71
GRIK3_HUMAN	Q13003	CHEMBL3684	Glutamate Receptor Ionotropic Kainate 3, Human	39
GRIK4_HUMAN	Q16099	CHEMBL2829	Glutamate Receptor Ionotropic Kainate 4, Human	28
GRIK5_HUMAN	Q16478	CHEMBL2675	Glutamate Receptor Ionotropic Kainate 5, Human	38

Activation of Na-permeable Kainate Receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	71

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GRIK1_RAT	P22756	CHEMBL2919	Glutamate Receptor Ionotropic Kainate 1, Rat	132	28	16	19

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	105	7	7	6
GRIK3_HUMAN	Q13003	CHEMBL3684	Glutamate Receptor Ionotropic Kainate 3, Human	39	6	4	4
GRIK4_HUMAN	Q16099	CHEMBL2829	Glutamate Receptor Ionotropic Kainate 4, Human	28	3	2	2
GRIK5_HUMAN	Q16478	CHEMBL2675	Glutamate Receptor Ionotropic Kainate 5, Human	50	11	7	12

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
GRIK1-1-E	Glutamate Receptor Ionotropic Kainate 1 (cluster #1 Of 3), Eukaryotic	37	9	6	6
GRIK1-2-E	Glutamate Receptor Ionotropic Kainate 1 (cluster #2 Of 3), Eukaryotic	115	21	2	1
GRIK1-3-E	Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic	100	14	12	14

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	71
GRIA1_HUMAN	P42261	CHEMBL2009	Glutamate Receptor Ionotropic, AMPA 1, Human	42
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	42
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	39
GRIK3_HUMAN	Q13003	CHEMBL3684	Glutamate Receptor Ionotropic Kainate 3, Human	39
GRIK5_HUMAN	Q16478	CHEMBL2675	Glutamate Receptor Ionotropic Kainate 5, Human	38
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	33
GRIK4_HUMAN	Q16099	CHEMBL2829	Glutamate Receptor Ionotropic Kainate 4, Human	28
GRIK1_RAT	P22756	CHEMBL2919	Glutamate Receptor Ionotropic Kainate 1, Rat	21
GRIA2_RAT	P19491	CHEMBL3503	Glutamate Receptor Ionotropic, AMPA 2, Rat	20
GRIA1_MOUSE	P23818	CHEMBL3502	Glutamate Receptor Ionotropic, AMPA 1, Mouse	18
GRIA3_RAT	P19492	CHEMBL3504	Glutamate Receptor Ionotropic, AMPA 3, Rat	18
GRIA1_RAT	P19490	CHEMBL3753	Glutamate Receptor Ionotropic, AMPA 1, Rat	16
GRIA4_RAT	P19493	CHEMBL3505	Glutamate Receptor Ionotropic, AMPA 4, Rat	16
GRIK2_RAT	P42260	CHEMBL3607	Glutamate Receptor Ionotropic Kainate 2, Rat	12
GRIK5_RAT	Q63273	CHEMBL4041	Glutamate Receptor Ionotropic Kainate 5, Rat	12
GRIK3_RAT	P42264	CHEMBL3744	Glutamate Receptor Ionotropic Kainate 3, Rat	11
GRIK4_RAT	Q01812	CHEMBL3044	Glutamate Receptor Ionotropic Kainate 4, Rat	11
GRIA2_MOUSE	P23819	CHEMBL3205	Glutamate Receptor Ionotropic, AMPA 2, Mouse	9
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	9
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	9
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	7
NMDE3_RAT	Q00961	CHEMBL401	Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat	3
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
GRM1_HUMAN	Q13255	CHEMBL3772	Metabotropic Glutamate Receptor 1, Human	2
GRM1_RAT	P23385	CHEMBL4477	Metabotropic Glutamate Receptor 1, Rat	2
GRM2_HUMAN	Q14416	CHEMBL5137	Metabotropic Glutamate Receptor 2, Human	2
GRM2_RAT	P31421	CHEMBL2851	Metabotropic Glutamate Receptor 2, Rat	2
GRM3_RAT	P31422	CHEMBL3067	Metabotropic Glutamate Receptor 3, Rat	2
GRM4_HUMAN	Q14833	CHEMBL2736	Metabotropic Glutamate Receptor 4, Human	2
GRM5_HUMAN	P41594	CHEMBL3227	Metabotropic Glutamate Receptor 5, Human	2
GRM5_RAT	P31424	CHEMBL2564	Metabotropic Glutamate Receptor 5, Rat	2
GRM8_MOUSE	P47743	CHEMBL4626	Metabotropic Glutamate Receptor 8, Mouse	2
NMDE1_RAT	Q00959	CHEMBL310	Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat	2
NMDE2_RAT	Q00960	CHEMBL311	Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat	2
NMDE4_RAT	Q62645	CHEMBL303	Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat	2
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	2
NMDZ1_RAT	P35439	CHEMBL330	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	2
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	2
EAA3_HUMAN	P43005	CHEMBL2721	Excitatory Amino Acid Transporter 3, Human	1
GRM1_MOUSE	P97772	CHEMBL2892	Metabotropic Glutamate Receptor 1, Mouse	1
GRM3_HUMAN	Q14832	CHEMBL2888	Metabotropic Glutamate Receptor 3, Human	1
GRM3_MOUSE	Q9QYS2	CHEMBL3824	Metabotropic Glutamate Receptor 3, Mouse	1
GRM4_RAT	P31423	CHEMBL2787	Metabotropic Glutamate Receptor 4, Rat	1
GRM6_HUMAN	O15303	CHEMBL4573	Metabotropic Glutamate Receptor 6, Human	1
GRM6_RAT	P35349	CHEMBL3842	Metabotropic Glutamate Receptor 6, Rat	1
GRM7_MOUSE	Q68ED2	CHEMBL3966	Metabotropic Glutamate Receptor 7, Mouse	1
GRM8_HUMAN	O00222	CHEMBL3228	Metabotropic Glutamate Receptor 8, Human	1
GRM8_RAT	P70579	CHEMBL2718	Metabotropic Glutamate Receptor 8, Rat	1
MURI_HELPY	P56068	CHEMBL6078	Glutamate Racemase, Helpy	1
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	1
NMD3A_RAT	Q9R1M7	CHEMBL342	Glutamate [NMDA] Receptor Subunit 3A, Rat	1
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	1
NMD3B_RAT	Q8VHN2	CHEMBL282	Glutamate [NMDA] Receptor Subunit 3B, Rat	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	1
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	1
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	1
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	1
Q80T35_MOUSE	Q80T35	CHEMBL3033	Metabotropic Glutamate Receptor 6, Mouse	1
Q80T43_MOUSE	Q80T43	CHEMBL3779	Metabotropic Glutamate Receptor 2, Mouse	1
Q80T47_MOUSE	Q80T47	CHEMBL2832	Metabotropic Glutamate Receptor 5, Mouse	1