ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (567)
Reactome (3)
Related By:
Pathway (8)
Organism (2)
Gene (3)
Org. Clust. (3)
ChEMBL (73)
Rings (15)

Glutamate Receptor Ionotropic, AMPA 1, Mouse (567 Compounds)

Swissprot:: GRIA1_MOUSE
Stitch:: GRIA1_MOUSE
UniProt:: P23818
ChEMBL:: CHEMBL3502
Reactome:: REACT_252788; REACT_253367; REACT_258217
PDB:: Gria1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	567	31	19	19
Binding ≤ 1μM	310	16	12	11
Functional ≤ 10μM	84	10	7	3

Reactome ID	Description	Species
REACT_252788	Activation of AMPA receptors	Mus musculus
REACT_253367	Trafficking of GluR2-containing AMPA receptors	Mus musculus
REACT_258217	Unblocking of NMDA receptor, glutamate binding and activation	Mus musculus

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	31
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	31

Trafficking of GluR2-containing AMPA receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	31
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	31

Unblocking of NMDA receptor, glutamate binding and activation

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	31
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	31
NMDE1_MOUSE	P35436	CHEMBL2521	Glutamate [NMDA] Receptor Subunit Epsilon 1, Mouse	1
NMDE3_MOUSE	Q01098	CHEMBL3555	Glutamate [NMDA] Receptor Subunit Epsilon 3, Mouse	1
NMDE4_MOUSE	Q03391	CHEMBL2893	Glutamate [NMDA] Receptor Subunit Epsilon 4, Mouse	1
NMDZ1_MOUSE	P35438	CHEMBL2895	Glutamate (NMDA) Receptor Subunit Zeta 1, Mouse	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GRIA1_HUMAN	P42261	CHEMBL2009	Glutamate Receptor Ionotropic, AMPA 1, Human	161	19	11	13
GRIA1_RAT	P19490	CHEMBL3753	Glutamate Receptor Ionotropic, AMPA 1, Rat	154	22	15	17

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
GRIA2_MOUSE	P23819	CHEMBL3205	Glutamate Receptor Ionotropic, AMPA 2, Mouse	25	5	4	3
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	25	5	4	3
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	25	5	4	3

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
GRIA1-1-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 4), Eukaryotic	199	21	9	14
GRIA1-2-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic	512	20	8	13
GRIA1-3-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic	30	4	5	4
GRIA1-4-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #4 Of 4), Eukaryotic	75	3	5	0

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA2_RAT	P19491	CHEMBL3503	Glutamate Receptor Ionotropic, AMPA 2, Rat	598
GRIA3_RAT	P19492	CHEMBL3504	Glutamate Receptor Ionotropic, AMPA 3, Rat	596
GRIA4_RAT	P19493	CHEMBL3505	Glutamate Receptor Ionotropic, AMPA 4, Rat	589
NMDZ1_RAT	P35439	CHEMBL330	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	152
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	143
GRIK1_RAT	P22756	CHEMBL2919	Glutamate Receptor Ionotropic Kainate 1, Rat	64
GRIK3_RAT	P42264	CHEMBL3744	Glutamate Receptor Ionotropic Kainate 3, Rat	63
GRIK2_RAT	P42260	CHEMBL3607	Glutamate Receptor Ionotropic Kainate 2, Rat	62
GRIK4_RAT	Q01812	CHEMBL3044	Glutamate Receptor Ionotropic Kainate 4, Rat	62
GRIK5_RAT	Q63273	CHEMBL4041	Glutamate Receptor Ionotropic Kainate 5, Rat	62
GRIA1_RAT	P19490	CHEMBL3753	Glutamate Receptor Ionotropic, AMPA 1, Rat	40
NMDE3_RAT	Q00961	CHEMBL401	Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat	39
NMD3A_RAT	Q9R1M7	CHEMBL342	Glutamate [NMDA] Receptor Subunit 3A, Rat	38
NMD3B_RAT	Q8VHN2	CHEMBL282	Glutamate [NMDA] Receptor Subunit 3B, Rat	38
NMDE1_RAT	Q00959	CHEMBL310	Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat	38
NMDE2_RAT	Q00960	CHEMBL311	Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat	38
NMDE4_RAT	Q62645	CHEMBL303	Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat	38
GRIA1_HUMAN	P42261	CHEMBL2009	Glutamate Receptor Ionotropic, AMPA 1, Human	33
GRIA2_MOUSE	P23819	CHEMBL3205	Glutamate Receptor Ionotropic, AMPA 2, Mouse	31
GRIA3_MOUSE	Q9Z2W9	CHEMBL3624	Glutamate Receptor Ionotropic, AMPA 3, Mouse	31
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	31
GRIA4_MOUSE	Q9Z2W8	CHEMBL3615	Glutamate Receptor Ionotropic, AMPA 4, Mouse	31
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	30
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	25
GRIK5_HUMAN	Q16478	CHEMBL2675	Glutamate Receptor Ionotropic Kainate 5, Human	19
GRIK1_HUMAN	P39086	CHEMBL1918	Glutamate Receptor Ionotropic Kainate 1, Human	18
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	15
GRIK3_HUMAN	Q13003	CHEMBL3684	Glutamate Receptor Ionotropic Kainate 3, Human	14
GRIK4_HUMAN	Q16099	CHEMBL2829	Glutamate Receptor Ionotropic Kainate 4, Human	12
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	12
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	8
GRM8_MOUSE	P47743	CHEMBL4626	Metabotropic Glutamate Receptor 8, Mouse	5
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	5
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	5
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	5
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	5
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	5
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	5
GLRA1_RAT	P07727	CHEMBL3246	Glycine Receptor Alpha-1 Chain, Rat	4
GLRA2_RAT	P22771	CHEMBL2328	Glycine Receptor Alpha-2 Chain, Rat	4
GLRA3_RAT	P24524	CHEMBL2677	Glycine Receptor Alpha-3 Chain, Rat	4
GLRB_RAT	P20781	CHEMBL4126	Glycine Receptor Beta Chain, Rat	4
GRM1_MOUSE	P97772	CHEMBL2892	Metabotropic Glutamate Receptor 1, Mouse	4
GRM3_MOUSE	Q9QYS2	CHEMBL3824	Metabotropic Glutamate Receptor 3, Mouse	4
GRM7_MOUSE	Q68ED2	CHEMBL3966	Metabotropic Glutamate Receptor 7, Mouse	4
Q80T35_MOUSE	Q80T35	CHEMBL3033	Metabotropic Glutamate Receptor 6, Mouse	4
Q80T43_MOUSE	Q80T43	CHEMBL3779	Metabotropic Glutamate Receptor 2, Mouse	4
Q80T47_MOUSE	Q80T47	CHEMBL2832	Metabotropic Glutamate Receptor 5, Mouse	4
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	3
GRM1_HUMAN	Q13255	CHEMBL3772	Metabotropic Glutamate Receptor 1, Human	3
GRM1_RAT	P23385	CHEMBL4477	Metabotropic Glutamate Receptor 1, Rat	3
GRM5_HUMAN	P41594	CHEMBL3227	Metabotropic Glutamate Receptor 5, Human	3
GRM5_RAT	P31424	CHEMBL2564	Metabotropic Glutamate Receptor 5, Rat	3
GLRA4_MOUSE	Q61603	CHEMBL3500	Glycine Receptor Alpha-4 Chain, Mouse	2
GRID1_HUMAN	Q9ULK0	CHEMBL2936	Glutamate Receptor Delta-1 Subunit, Human	2
GRM2_HUMAN	Q14416	CHEMBL5137	Metabotropic Glutamate Receptor 2, Human	2
GRM2_RAT	P31421	CHEMBL2851	Metabotropic Glutamate Receptor 2, Rat	2
GRM3_RAT	P31422	CHEMBL3067	Metabotropic Glutamate Receptor 3, Rat	2
GRM4_HUMAN	Q14833	CHEMBL2736	Metabotropic Glutamate Receptor 4, Human	2
Z50594	Z50594	CHEMBL375	Mus Musculus	2
EAA3_HUMAN	P43005	CHEMBL2721	Excitatory Amino Acid Transporter 3, Human	1
FOLH1_HUMAN	Q04609	CHEMBL1892	Glutamate Carboxypeptidase II, Human	1
GRIK2_XENLA	Q91755	CHEMBL3395	Glutamate Receptor Ionotropic Kainate 2, Xenla	1
GRM3_HUMAN	Q14832	CHEMBL2888	Metabotropic Glutamate Receptor 3, Human	1
GRM4_RAT	P31423	CHEMBL2787	Metabotropic Glutamate Receptor 4, Rat	1
GRM6_HUMAN	O15303	CHEMBL4573	Metabotropic Glutamate Receptor 6, Human	1
GRM6_RAT	P35349	CHEMBL3842	Metabotropic Glutamate Receptor 6, Rat	1
GRM8_HUMAN	O00222	CHEMBL3228	Metabotropic Glutamate Receptor 8, Human	1
GRM8_RAT	P70579	CHEMBL2718	Metabotropic Glutamate Receptor 8, Rat	1
MURI_HELPY	P56068	CHEMBL6078	Glutamate Racemase, Helpy	1
XCT_HUMAN	Q9UPY5	CHEMBL1075149	Cystine/glutamate Transporter, Human	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1
Z81252	Z81252	CHEMBL400	MDA-MB-231 (Breast Adenocarcinoma Cells)	1