ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (1,767)
Reactome (3)
Related By:
Pathway (11)
Organism (2)
Gene (0)
Org. Clust. (1)
ChEMBL (74)
Rings (50)

Peroxisome Proliferator-activated Receptor Gamma, Human (1,767 Compounds)

Swissprot:: PPARG_HUMAN
Stitch:: PPARG_HUMAN
UniProt:: P37231
ChEMBL:: CHEMBL235
Reactome:: REACT_15525; REACT_116145; REACT_27161
PDB:: 1FM6 (DOCK); 1FM9 (DOCK); 1I7I (DOCK); 1K74 (DOCK); 1KNU (DOCK); 1NYX (DOCK); 1PRG (DOCK); 1RDT (DOCK); 1WM0 (DOCK); 1ZEO (DOCK); 1ZGY (DOCK); 2ATH (DOCK); 2F4B (DOCK); 2FVJ (DOCK); 2G0G (DOCK); 2G0H (DOCK); 2GTK (DOCK); 2HFP (DOCK); 2HWQ (DOCK); 2HWR (DOCK); 2I4J (DOCK); 2I4P (DOCK); 2I4Z (DOCK); 2OM9 (DOCK); 2P4Y (DOCK); 2POB (DOCK); 2PRG (DOCK); 2Q59 (DOCK); 2Q5P (DOCK); 2Q5S (DOCK); 2Q61 (DOCK); 2Q6R (DOCK); 2Q6S (DOCK); 2Q8S (DOCK); 2QMV (DOCK); 2VSR (DOCK); 2VST (DOCK); 2VV0 (DOCK); 2VV1 (DOCK); 2VV2 (DOCK); 2VV3 (DOCK); 2VV4 (DOCK); 2XKW (DOCK); 2ZK0 (DOCK); 2ZK1 (DOCK); 2ZK2 (DOCK); 2ZK3 (DOCK); 2ZK4 (DOCK); 2ZK5 (DOCK); 2ZK6 (DOCK); 2ZNO (DOCK); 2ZVT (DOCK); 3ADS (DOCK); 3ADT (DOCK); 3ADU (DOCK); 3ADV (DOCK); 3ADW (DOCK); 3ADX (DOCK); 3AN3 (DOCK); 3AN4 (DOCK); 3B0Q (DOCK); 3B0R (DOCK); 3B1M (DOCK); 3B3K (DOCK); 3BC5 (DOCK); 3CDP (DOCK); 3CDS (DOCK); 3CS8 (DOCK); 3CWD (DOCK); 3D6D (DOCK); 3DZU (DOCK); 3DZY (DOCK); 3E00 (DOCK); 3ET0 (DOCK); 3ET3 (DOCK); 3FEJ (DOCK); 3FUR (DOCK); 3G9E (DOCK); 3GBK (DOCK); 3H0A (DOCK); 3HO0 (DOCK); 3HOD (DOCK); 3IA6 (DOCK); 3K8S (DOCK); 3KMG (DOCK); 3LMP (DOCK); 3NOA (DOCK); 3OSI (DOCK); 3OSW (DOCK); 3PBA (DOCK); 3PO9 (DOCK); 3PRG (DOCK); 3R8I (DOCK); 3TY0 (DOCK); 3U9Q (DOCK); 3V9T (DOCK); 3V9V (DOCK); 3V9Y (DOCK); 4PRG (DOCK); PPARG

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,767	48	20	29
Binding ≤ 1μM	1,164	23	11	19
Functional ≤ 10μM	1,733	48	18	28

Reactome ID	Description	Species
REACT_15525	Nuclear Receptor transcription pathway	Homo sapiens
REACT_116145	PPARA activates gene expression	Homo sapiens
REACT_27161	Transcriptional regulation of white adipocyte differentiation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
NR1H2_HUMAN	P55055	CHEMBL4093	LXR-beta, Human	18
PPARA_HUMAN	Q07869	CHEMBL239	Peroxisome Proliferator-activated Receptor Alpha, Human	1863
PPARD_HUMAN	Q03181	CHEMBL3979	Peroxisome Proliferator-activated Receptor Delta, Human	700
RARA_HUMAN	P10276	CHEMBL2055	Retinoic Acid Receptor Alpha, Human	13
RARB_HUMAN	P10826	CHEMBL2008	Retinoic Acid Receptor Beta, Human	15
RARG_HUMAN	P13631	CHEMBL2003	Retinoic Acid Receptor Gamma, Human	21
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	51
RXRB_HUMAN	P28702	CHEMBL1870	Retinoid X Receptor Beta, Human	17
RXRG_HUMAN	P48443	CHEMBL2004	Retinoid X Receptor Gamma, Human	17

PPARA activates gene expression

Uniprot	Swissprot	Chembl	Description	Number Shared
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	1
PPARA_HUMAN	Q07869	CHEMBL239	Peroxisome Proliferator-activated Receptor Alpha, Human	1863
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	51

Transcriptional regulation of white adipocyte differentiation

Uniprot	Swissprot	Chembl	Description	Number Shared
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	1
PPARA_HUMAN	Q07869	CHEMBL239	Peroxisome Proliferator-activated Receptor Alpha, Human	1863
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	51

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PPARG_MOUSE	P37238	CHEMBL2459	Peroxisome Proliferator-activated Receptor Gamma, Mouse	12	8	3	3
PPARG_RAT	O88275	CHEMBL4797	Peroxisome Proliferator-activated Receptor Gamma, Rat	91	6	5	5

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
PPARG-1-E	Peroxisome Proliferator-activated Receptor Gamma (cluster #1 Of 2), Eukaryotic	1,820	53	22	33
PPARG-2-E	Peroxisome Proliferator-activated Receptor Gamma (cluster #2 Of 2), Eukaryotic	17	3	2	0

Uniprot	Swissprot	Chembl	Description	Number Shared
PPARA_HUMAN	Q07869	CHEMBL239	Peroxisome Proliferator-activated Receptor Alpha, Human	1843
PPARD_HUMAN	Q03181	CHEMBL3979	Peroxisome Proliferator-activated Receptor Delta, Human	695
PPARG_RAT	O88275	CHEMBL4797	Peroxisome Proliferator-activated Receptor Gamma, Rat	73
PPARA_MOUSE	P23204	CHEMBL2128	Peroxisome Proliferator-activated Receptor Alpha, Mouse	53
PPARG_MOUSE	P37238	CHEMBL2459	Peroxisome Proliferator-activated Receptor Gamma, Mouse	52
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	51
Z80106	Z80106	CHEMBL614563	COS-1 (Kidney Cells)	35
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	21
PPARD_MOUSE	P35396	CHEMBL2458	Peroxisome Proliferator-activated Receptor Delta, Mouse	18
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	17
NR1H2_HUMAN	P55055	CHEMBL4093	LXR-beta, Human	17
NR1H3_HUMAN	Q13133	CHEMBL2808	LXR-alpha, Human	17
Z80169	Z80169	CHEMBL614039	Huh-7 (Hepatocellular Carcinoma)	14
PPARA_CANFA	Q95N78	CHEMBL2847	Peroxisome Proliferator-activated Receptor Alpha, Canine	13
PTGES_HUMAN	O14684	CHEMBL5658	Prostaglandin E Synthase, Human	12
Z81117	Z81117	CHEMBL613995	Keratinocytes (Keratinocytes)	10
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	9
AGTRA_RAT	P25095	CHEMBL329	Angiotensin II Type 1a (AT-1a) Receptor, Rat	8
AGTRB_RAT	P29089	CHEMBL263	Angiotensin II Type 1b (AT-1b) Receptor, Rat	8
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine Oxidase B, Human	8
PPARA_RAT	P37230	CHEMBL2129	Peroxisome Proliferator-activated Receptor Alpha, Rat	8
Z80166	Z80166	CHEMBL384	HT-29 (Colon Adenocarcinoma Cells)	8
Z80006	Z80006	CHEMBL614510	3T3-L1 (Fibroblast Cells)	7
Z80548	Z80548	CHEMBL614245	THP-1 (Acute Monocytic Leukemia Cells)	7
Z81244	Z81244	CHEMBL614123	J774 (Macrophage Cells)	5
Z81020	Z81020	CHEMBL395	HepG2 (Hepatoblastoma Cells)	4
Z81135	Z81135	CHEMBL614793	L6 (Skeletal Muscle Myoblast Cells)	3
RARG_HUMAN	P13631	CHEMBL2003	Retinoic Acid Receptor Gamma, Human	2
RXRA_RAT	Q05343	CHEMBL4431	Retinoid X Receptor Alpha, Rat	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
Z80110	Z80110	CHEMBL613507	CV-1 (Kidney Cells)	2
Z80561	Z80561	CHEMBL615023	U2OS (Osteosarcoma Cells)	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	1
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	1
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	1
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	1
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	1
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	1
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	1
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	1
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
FABPL_RAT	P02692	CHEMBL5738	Fatty Acid-binding Protein, Liver, Rat	1
GALE_HUMAN	Q14376	CHEMBL5843	UDP-glucose 4-epimerase, Human	1
HDA10_HUMAN	Q969S8	CHEMBL5103	Histone Deacetylase 10, Human	1
HDA11_HUMAN	Q96DB2	CHEMBL3310	Histone Deacetylase 11, Human	1
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	1
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	1
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	1
HDAC4_HUMAN	P56524	CHEMBL3524	Histone Deacetylase 4, Human	1
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	1
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	1
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	1
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	1
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	1
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	1
O53430_MYCTU	O53430	CHEMBL3703	Mycothiol S-conjugate Amidase, Myctu	1
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	1
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	1
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	1
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	1
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	1
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	1
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	1
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	1
Q7TNH1_MESAU	Q7TNH1	CHEMBL1075150	Peroxisome Proliferator Activated Receptor Alpha, Mesau	1
RXRB_HUMAN	P28702	CHEMBL1870	Retinoid X Receptor Beta, Human	1
RXRG_HUMAN	P48443	CHEMBL2004	Retinoid X Receptor Gamma, Human	1
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	1
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	1
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	1
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	1
Z80178	Z80178	CHEMBL614040	J774.A1 (Macrophage Cells)	1