UCSF

Histone Deacetylase 8, Human (715 Compounds)

Swissprot:
HDAC8_HUMAN
Stitch:
HDAC8_HUMAN
UniProt:
Q9BY41
ChEMBL:
CHEMBL3192
Reactome:
REACT_160254
REACT_160243
REACT_228222
REACT_118780
PDB:
1T64 (DOCK)
1T67 (DOCK)
1T69 (DOCK)
1VKG (DOCK)
1W22 (DOCK)
2V5W (DOCK)
2V5X (DOCK)
3EW8 (DOCK)
3EWF (DOCK)
3EZP (DOCK)
3EZT (DOCK)
3F06 (DOCK)
3F07 (DOCK)
3F0R (DOCK)
3MZ3 (DOCK)
3MZ4 (DOCK)
3MZ6 (DOCK)
3MZ7 (DOCK)
3RQD (DOCK)
3SFF (DOCK)
3SFH (DOCK)
HDAC8

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 715 26 10 11
Binding ≤ 1μM 491 21 8 9
Functional ≤ 10μM 37 4 2 5

Reactome Network (4)

Reactome ID Description Species
REACT_160254 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Homo sapiens
REACT_160243 Constitutive Signaling by NOTCH1 PEST Domain Mutants Homo sapiens
REACT_228222 HDACs deacetylate histones Homo sapiens
REACT_118780 NOTCH1 Intracellular Domain Regulates Transcription Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 462
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 416
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 605
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 528
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 526
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 459
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 457
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 584
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 450
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 452
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 462
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 416
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 605
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 528
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 526
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 459
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 457
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 584
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 450
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 452
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

HDACs deacetylate histones

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 462
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 605
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 528
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 526
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 462
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 416
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 605
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 528
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 526
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 459
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 457
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 584
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 450
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 452
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 10 1 0 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 1,826 45 16 13
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 708 36 14 13
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 619 33 15 14
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 585 27 12 11
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 475 26 10 11
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 845 33 9 12
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 465 25 10 11
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 462 24 9 11

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
HDAC8-1-E Histone Deacetylase 8 (cluster #1 Of 4), Eukaryotic 662 22 9 9
HDAC8-2-E Histone Deacetylase 8 (cluster #2 Of 4), Eukaryotic 45 4 1 2
HDAC8-3-E Histone Deacetylase 8 (cluster #3 Of 4), Eukaryotic 1 0 0 0
HDAC8-4-E Histone Deacetylase 8 (cluster #4 Of 4), Eukaryotic 27 2 0 0
Uniprot Swissprot Chembl Description Number Shared
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 605
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 584
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 528
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 526
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 462
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 459
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 457
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 452
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 450
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 416
Q94F81_MAIZE Q94F81 CHEMBL4919 Histone Deacetylase HD2, Maize 48
B1WBY8_RAT B1WBY8 CHEMBL4705 Histone Deacetylase 2, Rat 32
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 32
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 32
HDAC4_RAT Q99P99 CHEMBL2874 Histone Deacetylase 4, Rat 32
HDAC7_RAT Q99P96 CHEMBL2914 Histone Deacetylase 7, Rat 32
Q5RJZ2_RAT Q5RJZ2 CHEMBL4025 Histone Deacetylase 5, Rat 32
Q99P97_RAT Q99P97 CHEMBL3101 Histone Deacetylase 6, Rat 32
Q7YY76_CRYPV Q7YY76 CHEMBL3626 Histone Deacetylase, Crypv 27
Q7YY07_CRYPV Q7YY07 CHEMBL4740 Histone Deacetylase, Crypv 25
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 21
Q9ZTP8_MAIZE Q9ZTP8 CHEMBL3541 Histone Deacetylase HD1B, Maize 17
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 9
HDAC1_CHICK P56517 CHEMBL4582 Histone Deacetylase 1, Chick 8
HDAC2_CHICK P56519 CHEMBL4583 Histone Deacetylase 2, Chick 8
HDAC3_CHICK P56520 CHEMBL4584 Histone Deacetylase 3, Chick 8
HDAC4_CHICK P83038 CHEMBL5599 Histone Deacetylase 4, Chick 8
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 7
Q9XYC7_PLAFA Q9XYC7 CHEMBL5541 Histone Deacetylase, Plafa 5
Z80877 Z80877 CHEMBL612255 NCI-H1299 (Non-small Cell Lung Carcinoma) 5
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 4
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 4
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 4
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 4
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 3
HDAH_ALCSD Q70I53 CHEMBL6017 Histone Deacetylase-like Amidohydrolase, Alcsd 3
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 3
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 3
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 3
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 3
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 3
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 3
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 3
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 3
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 3
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 3
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 2
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 2
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z80269 Z80269 CHEMBL614354 MKN-45 (Gastric Adenocarcinoma Cells) 2
Z80513 Z80513 CHEMBL614939 SQ20B 2
Z80525 Z80525 CHEMBL614055 SW48 2
Z80857 Z80857 CHEMBL614499 Friend Leukemia Cell Line 2
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 2
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 2
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 2
Z81199 Z81199 CHEMBL612440 NCI-H446 (Small Cell Lung Carcinoma Cells) 2
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 2
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
GALE_HUMAN Q14376 CHEMBL5843 UDP-glucose 4-epimerase, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
O53430_MYCTU O53430 CHEMBL3703 Mycothiol S-conjugate Amidase, Myctu 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
Q7K6A1_PLAF7 Q7K6A1 CHEMBL1293190 Histone Deacetylase, Plaf7 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
SF3B3_HUMAN Q15393 CHEMBL1250378 Splicing Factor 3B Subunit 3, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
Z102015 Z102015 CHEMBL613013 Plasmodium Vivax 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z103348 Z103348 CHEMBL1075533 NCI-H2122 1
Z103359 Z103359 CHEMBL1075544 NCI-H661 1
Z50136 Z50136 CHEMBL612608 Plasmodium Falciparum (isolate FcB1 / Columbia) 1
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80123 Z80123 CHEMBL614287 DO4 (Melanoma Cells) 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 1
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 1
Z80277 Z80277 CHEMBL614170 MM96L (Melanoma Cells) 1
Z80322 Z80322 CHEMBL614135 NCI-H358 (Lung Carcinama Cells) 1
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 1
Z80514 Z80514 CHEMBL614166 St-4 (Stomach Carcinoma Cells) 1
Z80725 Z80725 CHEMBL613540 C180-13S (Ovarian Carcinoma Cells) 1
Z80838 Z80838 CHEMBL614489 EOL1 (Eosinophilic Cells) 1
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 1
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 1
Z80896 Z80896 CHEMBL614805 NCI-H69 (Small Cell Lung Carcinoma Cells) 1
Z80957 Z80957 CHEMBL614734 HMEC (Microvascular Endothelial Cells) 1
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 1
Z81070 Z81070 CHEMBL613987 JAM Cell Line 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81184 Z81184 CHEMBL614096 LOX IMVI (Melanoma Cells) 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1
Z81280 Z81280 CHEMBL614740 NCI-H226 (Non-small Cell Lung Carcinoma Cells) 1
Z81281 Z81281 CHEMBL614997 NCI-H23 (Non-small Cell Lung Carcinoma Cells) 1
Z81283 Z81283 CHEMBL614387 NCI-H522 (Non-small Cell Lung Carcinoma Cells) 1
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 1

Most Common Rings