ZINC 12

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Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	21	1	1	0
Binding ≤ 1μM	15	1	1	0

Reactome ID	Description	Species
REACT_198082	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Gallus gallus
REACT_198075	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Gallus gallus
REACT_203522	deactivation of the beta-catenin transactivating complex	Gallus gallus
REACT_197541	Factors involved in megakaryocyte development and platelet production	Gallus gallus
REACT_203085	formation of the beta-catenin:TCF transactivating complex	Gallus gallus
REACT_197098	G0 and Early G1	Gallus gallus
REACT_223355	NoRC negatively regulates rRNA expression	Gallus gallus
REACT_198137	NOTCH1 Intracellular Domain Regulates Transcription	Gallus gallus
REACT_209209	p75NTR negatively regulates cell cycle via SC1	Gallus gallus
REACT_256537	repression of WNT target genes	Gallus gallus
REACT_248417	RNA Polymerase I Transcription Initiation	Gallus gallus

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	1,826	45	16	13
HDAC1_MOUSE	O09106	CHEMBL4001	Histone Deacetylase 1, Mouse	26	3	1	2
HDAC1_RAT	Q4QQW4	CHEMBL2915	Histone Deacetylase 1, Rat	76	8	1	4

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural
HDAC2_CHICK	P56519	CHEMBL4583	Histone Deacetylase 2, Chick	21	1	1
HDAC3_CHICK	P56520	CHEMBL4584	Histone Deacetylase 3, Chick	21	1	1
HDAC4_CHICK	P83038	CHEMBL5599	Histone Deacetylase 4, Chick	21	1	1

Code	Description	Substances	Purchasable	Natural	In Man
HDAC1-1-E	Histone Deacetylase 1 (cluster #1 Of 4), Eukaryotic	1,131	29	13	8
HDAC1-2-E	Histone Deacetylase 1 (cluster #2 Of 4), Eukaryotic	667	10	2	5
HDAC1-3-E	Histone Deacetylase 1 (cluster #3 Of 4), Eukaryotic	12	6	1	1
HDAC1-4-E	Histone Deacetylase 1 (cluster #4 Of 4), Eukaryotic	98	3	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
HDAC2_CHICK	P56519	CHEMBL4583	Histone Deacetylase 2, Chick	21
HDAC3_CHICK	P56520	CHEMBL4584	Histone Deacetylase 3, Chick	21
HDAC4_CHICK	P83038	CHEMBL5599	Histone Deacetylase 4, Chick	21
Q7YY76_CRYPV	Q7YY76	CHEMBL3626	Histone Deacetylase, Crypv	19
Q7YY07_CRYPV	Q7YY07	CHEMBL4740	Histone Deacetylase, Crypv	10
HDA10_HUMAN	Q969S8	CHEMBL5103	Histone Deacetylase 10, Human	8
HDA11_HUMAN	Q96DB2	CHEMBL3310	Histone Deacetylase 11, Human	8
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	8
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	8
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	8
HDAC4_HUMAN	P56524	CHEMBL3524	Histone Deacetylase 4, Human	8
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	8
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	8
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	8
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	8
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	8
HDAH_ALCSD	Q70I53	CHEMBL6017	Histone Deacetylase-like Amidohydrolase, Alcsd	1
NCOR2_HUMAN	Q9Y618	CHEMBL5949	Nuclear Receptor Corepressor 2, Human	1
Q9XYC7_PLAFA	Q9XYC7	CHEMBL5541	Histone Deacetylase, Plafa	1
TF_HUMAN	P13726	CHEMBL4081	Coagulation Factor III, Human	1