UCSF

Histone Deacetylase 11, Human (404 Compounds)

Swissprot:
HDA11_HUMAN
Stitch:
HDA11_HUMAN
UniProt:
Q96DB2
ChEMBL:
CHEMBL3310
Reactome:
REACT_160254
REACT_160243
REACT_118780
PDB:
HDAC11

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 404 20 10 10
Binding ≤ 1μM 301 17 9 8
Functional ≤ 10μM 24 4 2 4
Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 418
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 419
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 416
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 419
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 415
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 417
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 418
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 410
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 416
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 415
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 3

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 418
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 419
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 416
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 419
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 415
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 417
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 418
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 410
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 416
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 415
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 3

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 418
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 419
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 416
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 419
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 415
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 417
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 418
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 410
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 416
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 415
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 2 1 0 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 460 22 9 9
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 1,826 45 16 13
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 708 36 14 13
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 619 33 15 14
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 585 27 12 11
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 475 26 10 11
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 845 33 9 12
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 465 25 10 11
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 715 26 10 11
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 462 24 9 11

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
HDA11-1-E Histone Deacetylase 11 (cluster #1 Of 3), Eukaryotic 158 15 3 7
HDA11-2-E Histone Deacetylase 11 (cluster #2 Of 3), Eukaryotic 83 1 4 0
HDA11-3-E Histone Deacetylase 11 (cluster #3 Of 3), Eukaryotic 173 6 3 3
Uniprot Swissprot Chembl Description Number Shared
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 419
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 419
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 418
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 418
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 417
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 416
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 416
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 415
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 415
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 410
B1WBY8_RAT B1WBY8 CHEMBL4705 Histone Deacetylase 2, Rat 31
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 31
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 31
HDAC4_RAT Q99P99 CHEMBL2874 Histone Deacetylase 4, Rat 31
HDAC7_RAT Q99P96 CHEMBL2914 Histone Deacetylase 7, Rat 31
Q5RJZ2_RAT Q5RJZ2 CHEMBL4025 Histone Deacetylase 5, Rat 31
Q99P97_RAT Q99P97 CHEMBL3101 Histone Deacetylase 6, Rat 31
Q7YY76_CRYPV Q7YY76 CHEMBL3626 Histone Deacetylase, Crypv 27
Q7YY07_CRYPV Q7YY07 CHEMBL4740 Histone Deacetylase, Crypv 25
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 21
Q94F81_MAIZE Q94F81 CHEMBL4919 Histone Deacetylase HD2, Maize 19
HDAC1_CHICK P56517 CHEMBL4582 Histone Deacetylase 1, Chick 8
HDAC2_CHICK P56519 CHEMBL4583 Histone Deacetylase 2, Chick 8
HDAC3_CHICK P56520 CHEMBL4584 Histone Deacetylase 3, Chick 8
HDAC4_CHICK P83038 CHEMBL5599 Histone Deacetylase 4, Chick 8
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 7
Q9XYC7_PLAFA Q9XYC7 CHEMBL5541 Histone Deacetylase, Plafa 5
Z80877 Z80877 CHEMBL612255 NCI-H1299 (Non-small Cell Lung Carcinoma) 5
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 4
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 3
HDAH_ALCSD Q70I53 CHEMBL6017 Histone Deacetylase-like Amidohydrolase, Alcsd 3
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 3
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 3
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 3
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 3
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 3
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 3
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 3
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 3
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 2
HDAC3_MOUSE O88895 CHEMBL5142 Histone Deacetylase 3, Mouse 2
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 2
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2
Q9ZTP8_MAIZE Q9ZTP8 CHEMBL3541 Histone Deacetylase HD1B, Maize 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z80269 Z80269 CHEMBL614354 MKN-45 (Gastric Adenocarcinoma Cells) 2
Z80513 Z80513 CHEMBL614939 SQ20B 2
Z80525 Z80525 CHEMBL614055 SW48 2
Z80857 Z80857 CHEMBL614499 Friend Leukemia Cell Line 2
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 2
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 2
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 2
Z81199 Z81199 CHEMBL612440 NCI-H446 (Small Cell Lung Carcinoma Cells) 2
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 2
GALE_HUMAN Q14376 CHEMBL5843 UDP-glucose 4-epimerase, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
O53430_MYCTU O53430 CHEMBL3703 Mycothiol S-conjugate Amidase, Myctu 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
Q7K6A1_PLAF7 Q7K6A1 CHEMBL1293190 Histone Deacetylase, Plaf7 1
SF3B3_HUMAN Q15393 CHEMBL1250378 Splicing Factor 3B Subunit 3, Human 1
Z102015 Z102015 CHEMBL613013 Plasmodium Vivax 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z103348 Z103348 CHEMBL1075533 NCI-H2122 1
Z103359 Z103359 CHEMBL1075544 NCI-H661 1
Z50136 Z50136 CHEMBL612608 Plasmodium Falciparum (isolate FcB1 / Columbia) 1
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80123 Z80123 CHEMBL614287 DO4 (Melanoma Cells) 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 1
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 1
Z80277 Z80277 CHEMBL614170 MM96L (Melanoma Cells) 1
Z80322 Z80322 CHEMBL614135 NCI-H358 (Lung Carcinama Cells) 1
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 1
Z80514 Z80514 CHEMBL614166 St-4 (Stomach Carcinoma Cells) 1
Z80725 Z80725 CHEMBL613540 C180-13S (Ovarian Carcinoma Cells) 1
Z80838 Z80838 CHEMBL614489 EOL1 (Eosinophilic Cells) 1
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 1
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 1
Z80896 Z80896 CHEMBL614805 NCI-H69 (Small Cell Lung Carcinoma Cells) 1
Z80957 Z80957 CHEMBL614734 HMEC (Microvascular Endothelial Cells) 1
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 1
Z81070 Z81070 CHEMBL613987 JAM Cell Line 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81184 Z81184 CHEMBL614096 LOX IMVI (Melanoma Cells) 1
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1
Z81280 Z81280 CHEMBL614740 NCI-H226 (Non-small Cell Lung Carcinoma Cells) 1
Z81281 Z81281 CHEMBL614997 NCI-H23 (Non-small Cell Lung Carcinoma Cells) 1
Z81283 Z81283 CHEMBL614387 NCI-H522 (Non-small Cell Lung Carcinoma Cells) 1
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 1