ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (585)
Reactome (3)
Related By:
Pathway (21)
Organism (2)
Gene (8)
Org. Clust. (2)
ChEMBL (109)
Rings (39)

Histone Deacetylase 4, Human (585 Compounds)

Swissprot:: HDAC4_HUMAN
Stitch:: HDAC4_HUMAN
UniProt:: P56524
ChEMBL:: CHEMBL3524
Reactome:: REACT_160254; REACT_160243; REACT_118780
PDB:: 2H8N (DOCK); 2O94 (DOCK); 2VQJ (DOCK); 2VQM (DOCK); 2VQO (DOCK); 2VQQ (DOCK); 2VQV (DOCK); 2VQW (DOCK); HDAC4

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	585	27	12	11
Binding ≤ 1μM	436	22	9	9
Functional ≤ 10μM	46	4	2	5

Reactome ID	Description	Species
REACT_160254	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Homo sapiens
REACT_160243	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Homo sapiens
REACT_118780	NOTCH1 Intracellular Domain Regulates Transcription	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
HDA10_HUMAN	Q969S8	CHEMBL5103	Histone Deacetylase 10, Human	417
HDA11_HUMAN	Q96DB2	CHEMBL3310	Histone Deacetylase 11, Human	415
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	560
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	461
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	477
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	490
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	497
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	488
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	459
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	482
NCOR2_HUMAN	Q9Y618	CHEMBL5949	Nuclear Receptor Corepressor 2, Human	5

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
HDA10_HUMAN	Q969S8	CHEMBL5103	Histone Deacetylase 10, Human	417
HDA11_HUMAN	Q96DB2	CHEMBL3310	Histone Deacetylase 11, Human	415
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	560
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	461
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	477
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	490
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	497
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	488
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	459
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	482
NCOR2_HUMAN	Q9Y618	CHEMBL5949	Nuclear Receptor Corepressor 2, Human	5

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot	Swissprot	Chembl	Description	Number Shared
HDA10_HUMAN	Q969S8	CHEMBL5103	Histone Deacetylase 10, Human	417
HDA11_HUMAN	Q96DB2	CHEMBL3310	Histone Deacetylase 11, Human	415
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	560
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	461
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	477
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	490
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	497
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	488
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	459
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	482
NCOR2_HUMAN	Q9Y618	CHEMBL5949	Nuclear Receptor Corepressor 2, Human	5

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HDAC4_CHICK	P83038	CHEMBL5599	Histone Deacetylase 4, Chick	21	1	1	0
HDAC4_RAT	Q99P99	CHEMBL2874	Histone Deacetylase 4, Rat	61	8	1	3

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	1,826	45	16	13
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	708	36	14	13
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	619	33	15	14
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	475	26	10	11
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	845	33	9	12
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	465	25	10	11
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	715	26	10	11
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	462	24	9	11

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
HDAC4-1-E	Histone Deacetylase 4 (cluster #1 Of 3), Eukaryotic	375	21	5	6
HDAC4-2-E	Histone Deacetylase 4 (cluster #2 Of 3), Eukaryotic	223	5	6	3
HDAC4-3-E	Histone Deacetylase 4 (cluster #3 Of 3), Eukaryotic	40	5	1	2

Uniprot	Swissprot	Chembl	Description	Number Shared
HDAC1_HUMAN	Q13547	CHEMBL325	Histone Deacetylase 1, Human	556
HDAC6_HUMAN	Q9UBN7	CHEMBL1865	Histone Deacetylase 6, Human	497
HDAC5_HUMAN	Q9UQL6	CHEMBL2563	Histone Deacetylase 5, Human	490
HDAC7_HUMAN	Q8WUI4	CHEMBL2716	Histone Deacetylase 7, Human	488
HDAC9_HUMAN	Q9UKV0	CHEMBL4145	Histone Deacetylase 9, Human	482
HDAC3_HUMAN	O15379	CHEMBL1829	Histone Deacetylase 3, Human	477
HDAC2_HUMAN	Q92769	CHEMBL1937	Histone Deacetylase 2, Human	461
HDAC8_HUMAN	Q9BY41	CHEMBL3192	Histone Deacetylase 8, Human	459
HDA10_HUMAN	Q969S8	CHEMBL5103	Histone Deacetylase 10, Human	417
HDA11_HUMAN	Q96DB2	CHEMBL3310	Histone Deacetylase 11, Human	415
Q94F81_MAIZE	Q94F81	CHEMBL4919	Histone Deacetylase HD2, Maize	71
Q9ZTP8_MAIZE	Q9ZTP8	CHEMBL3541	Histone Deacetylase HD1B, Maize	43
B1WBY8_RAT	B1WBY8	CHEMBL4705	Histone Deacetylase 2, Rat	31
HDAC1_RAT	Q4QQW4	CHEMBL2915	Histone Deacetylase 1, Rat	31
HDAC3_RAT	Q6P6W3	CHEMBL2628	Histone Deacetylase 3, Rat	31
HDAC4_RAT	Q99P99	CHEMBL2874	Histone Deacetylase 4, Rat	31
HDAC7_RAT	Q99P96	CHEMBL2914	Histone Deacetylase 7, Rat	31
Q5RJZ2_RAT	Q5RJZ2	CHEMBL4025	Histone Deacetylase 5, Rat	31
Q99P97_RAT	Q99P97	CHEMBL3101	Histone Deacetylase 6, Rat	31
HDAC6_MOUSE	Q9Z2V5	CHEMBL2878	Histone Deacetylase 6, Mouse	30
Z80928	Z80928	CHEMBL394	HCT-116 (Colon Carcinoma Cells)	28
Q7YY76_CRYPV	Q7YY76	CHEMBL3626	Histone Deacetylase, Crypv	27
Q7YY07_CRYPV	Q7YY07	CHEMBL4740	Histone Deacetylase, Crypv	25
HDAC1_MOUSE	O09106	CHEMBL4001	Histone Deacetylase 1, Mouse	16
HDAC1_CHICK	P56517	CHEMBL4582	Histone Deacetylase 1, Chick	8
HDAC2_CHICK	P56519	CHEMBL4583	Histone Deacetylase 2, Chick	8
HDAC3_CHICK	P56520	CHEMBL4584	Histone Deacetylase 3, Chick	8
HDAC4_CHICK	P83038	CHEMBL5599	Histone Deacetylase 4, Chick	8
Z80682	Z80682	CHEMBL392	A549 (Lung Carcinoma Cells)	7
Z80125	Z80125	CHEMBL613508	DU-145 (Prostate Carcinoma)	6
Z80224	Z80224	CHEMBL387	MCF7 (Breast Carcinoma Cells)	6
Z80532	Z80532	CHEMBL614774	T-24 (Bladder Carcinoma Cells)	6
Z81252	Z81252	CHEMBL400	MDA-MB-231 (Breast Adenocarcinoma Cells)	6
NCOR2_HUMAN	Q9Y618	CHEMBL5949	Nuclear Receptor Corepressor 2, Human	5
Q9XYC7_PLAFA	Q9XYC7	CHEMBL5541	Histone Deacetylase, Plafa	5
Z80525	Z80525	CHEMBL614055	SW48	5
Z80877	Z80877	CHEMBL612255	NCI-H1299 (Non-small Cell Lung Carcinoma)	5
Z81199	Z81199	CHEMBL612440	NCI-H446 (Small Cell Lung Carcinoma Cells)	5
HDAH_ALCSD	Q70I53	CHEMBL6017	Histone Deacetylase-like Amidohydrolase, Alcsd	3
TF_HUMAN	P13726	CHEMBL4081	Coagulation Factor III, Human	3
Z80475	Z80475	CHEMBL613834	SK-BR-3 (Breast Adenocarcinoma)	3
Z81331	Z81331	CHEMBL612262	SW-620 (Colon Adenocarcinoma Cells)	3
HDA11_MOUSE	Q91WA3	CHEMBL5143	Histone Deacetylase 11, Mouse	2
HDAC2_MOUSE	P70288	CHEMBL4238	Histone Deacetylase 2, Mouse	2
HDAC3_MOUSE	O88895	CHEMBL5142	Histone Deacetylase 3, Mouse	2
HDAC5_MOUSE	Q9Z2V6	CHEMBL2768	Histone Deacetylase 5, Mouse	2
HDAC7_MOUSE	Q8C2B3	CHEMBL4219	Histone Deacetylase 7, Mouse	2
HDAC8_MOUSE	Q8VH37	CHEMBL2347	Histone Deacetylase 8, Mouse	2
HDAC9_MOUSE	Q99N13	CHEMBL5204	Histone Deacetylase 9, Mouse	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
Z80269	Z80269	CHEMBL614354	MKN-45 (Gastric Adenocarcinoma Cells)	2
Z80513	Z80513	CHEMBL614939	SQ20B	2
Z80851	Z80851	CHEMBL614496	Fibroblast MRHFcell Line	2
Z80857	Z80857	CHEMBL614499	Friend Leukemia Cell Line	2
Z80957	Z80957	CHEMBL614734	HMEC (Microvascular Endothelial Cells)	2
Z81020	Z81020	CHEMBL395	HepG2 (Hepatoblastoma Cells)	2
Z81034	Z81034	CHEMBL614004	A2780 (Ovarian Carcinoma Cells)	2
Z81170	Z81170	CHEMBL612518	LNCaP (Prostate Carcinoma)	2
Z81247	Z81247	CHEMBL399	HeLa (Cervical Adenocarcinoma Cells)	2
ABL1_HUMAN	P00519	CHEMBL1862	Tyrosine-protein Kinase ABL, Human	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
ERBB2_HUMAN	P04626	CHEMBL1824	Receptor Protein-tyrosine Kinase ErbB-2, Human	1
FGFR2_HUMAN	P21802	CHEMBL4142	Fibroblast Growth Factor Receptor 2, Human	1
FLT3_HUMAN	P36888	CHEMBL1974	Tyrosine-protein Kinase Receptor FLT3, Human	1
GALE_HUMAN	Q14376	CHEMBL5843	UDP-glucose 4-epimerase, Human	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
LCK_HUMAN	P06239	CHEMBL258	Tyrosine-protein Kinase LCK, Human	1
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	1
O53430_MYCTU	O53430	CHEMBL3703	Mycothiol S-conjugate Amidase, Myctu	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
Q7K6A1_PLAF7	Q7K6A1	CHEMBL1293190	Histone Deacetylase, Plaf7	1
RET_HUMAN	P07949	CHEMBL2041	Tyrosine-protein Kinase Receptor RET, Human	1
SF3B3_HUMAN	Q15393	CHEMBL1250378	Splicing Factor 3B Subunit 3, Human	1
VGFR2_HUMAN	P35968	CHEMBL279	Vascular Endothelial Growth Factor Receptor 2, Human	1
Z102015	Z102015	CHEMBL613013	Plasmodium Vivax	1
Z103205	Z103205	CHEMBL1075390	A431	1
Z103348	Z103348	CHEMBL1075533	NCI-H2122	1
Z103359	Z103359	CHEMBL1075544	NCI-H661	1
Z50136	Z50136	CHEMBL612608	Plasmodium Falciparum (isolate FcB1 / Columbia)	1
Z80054	Z80054	CHEMBL614058	Caco-2 (Colon Adenocarcinoma Cells)	1
Z80064	Z80064	CHEMBL382	CCRF-CEM (T-cell Leukemia)	1
Z80123	Z80123	CHEMBL614287	DO4 (Melanoma Cells)	1
Z80156	Z80156	CHEMBL383	HL-60 (Promyeloblast Leukemia Cells)	1
Z80164	Z80164	CHEMBL614580	HT-1080 (Fibrosarcoma Cells)	1
Z80166	Z80166	CHEMBL384	HT-29 (Colon Adenocarcinoma Cells)	1
Z80186	Z80186	CHEMBL385	K562 (Erythroleukemia Cells)	1
Z80244	Z80244	CHEMBL614335	MDA-MB-468 (Breast Adenocarcinoma)	1
Z80277	Z80277	CHEMBL614170	MM96L (Melanoma Cells)	1
Z80322	Z80322	CHEMBL614135	NCI-H358 (Lung Carcinama Cells)	1
Z80390	Z80390	CHEMBL390	PC-3 (Prostate Carcinoma Cells)	1
Z80418	Z80418	CHEMBL612557	RAW264.7 (Monocytic-macrophage Leukemia Cells)	1
Z80485	Z80485	CHEMBL614919	SK-MEL-28 (Melanoma Cells)	1
Z80493	Z80493	CHEMBL614925	SK-OV-3 (Ovarian Carcinoma Cells)	1
Z80514	Z80514	CHEMBL614166	St-4 (Stomach Carcinoma Cells)	1
Z80725	Z80725	CHEMBL613540	C180-13S (Ovarian Carcinoma Cells)	1
Z80838	Z80838	CHEMBL614489	EOL1 (Eosinophilic Cells)	1
Z80852	Z80852	CHEMBL614069	A-431 (Epidermoid Carcinoma Cells)	1
Z80874	Z80874	CHEMBL393	CEM (T-cell Leukemia)	1
Z80896	Z80896	CHEMBL614805	NCI-H69 (Small Cell Lung Carcinoma Cells)	1
Z81024	Z81024	CHEMBL396	NCI-H460 (Non-small Cell Lung Carcinoma)	1
Z81070	Z81070	CHEMBL613987	JAM Cell Line	1
Z81072	Z81072	CHEMBL397	Jurkat (Acute Leukemic T-cells)	1
Z81184	Z81184	CHEMBL614096	LOX IMVI (Melanoma Cells)	1
Z81186	Z81186	CHEMBL614097	LS174T (Colon Adencocarcinoma Cells)	1
Z81245	Z81245	CHEMBL614697	MDA-MB-435 (Breast Carcinoma Cells)	1
Z81280	Z81280	CHEMBL614740	NCI-H226 (Non-small Cell Lung Carcinoma Cells)	1
Z81281	Z81281	CHEMBL614997	NCI-H23 (Non-small Cell Lung Carcinoma Cells)	1
Z81283	Z81283	CHEMBL614387	NCI-H522 (Non-small Cell Lung Carcinoma Cells)	1
Z81335	Z81335	CHEMBL612263	HCT-15 (Colon Adenocarcinoma Cells)	1