UCSF

Histone Deacetylase 3, Mouse (2 Compounds)

Swissprot:
HDAC3_MOUSE
Stitch:
HDAC3_MOUSE
UniProt:
O88895
ChEMBL:
CHEMBL5142
Reactome:
REACT_198620
REACT_241925
REACT_196591
REACT_196589
REACT_257106
REACT_196464
REACT_202086
REACT_198602
REACT_257219
REACT_198352
REACT_198351
REACT_27166
REACT_252217
PDB:
Hdac3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2 1 0 1
Binding ≤ 1μM 2 1 0 1

Reactome Network (13)

Reactome ID Description Species
REACT_198620 BMAL1:CLOCK,NPAS2 activates circadian gene expression Mus musculus
REACT_241925 Circadian Clock Mus musculus
REACT_196591 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mus musculus
REACT_196589 Constitutive Signaling by NOTCH1 PEST Domain Mutants Mus musculus
REACT_257106 HDACs deacetylate histones Mus musculus
REACT_196464 NOTCH1 Intracellular Domain Regulates Transcription Mus musculus
REACT_202086 p75NTR negatively regulates cell cycle via SC1 Mus musculus
REACT_198602 PPARA activates gene expression Mus musculus
REACT_257219 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp Mus musculus
REACT_198352 REV-ERBA represses gene expression Mus musculus
REACT_198351 RORA activates circadian gene expression Mus musculus
REACT_27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Mus musculus
REACT_252217 Transcriptional regulation of white adipocyte differentiation Mus musculus
Uniprot Swissprot Chembl Description Number Shared
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2

HDACs deacetylate histones

Uniprot Swissprot Chembl Description Number Shared
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 2
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 2

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2

p75NTR negatively regulates cell cycle via SC1

Uniprot Swissprot Chembl Description Number Shared
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC3_CHICK P56520 CHEMBL4584 Histone Deacetylase 3, Chick 21 1 1 0
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 619 33 15 14
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 61 8 1 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 26 3 1 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 8 1 0 1
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 11 1 0 1
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 40 1 0 1
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2 1 0 1
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 10 1 0 1
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2 1 0 1

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
HDAC3-1-E Histone Deacetylase 3 (cluster #1 Of 3), Eukaryotic 560 25 10 10
HDAC3-2-E Histone Deacetylase 3 (cluster #2 Of 3), Eukaryotic 107 8 4 3
HDAC3-3-E Histone Deacetylase 3 (cluster #3 Of 3), Eukaryotic 4 3 1 1
Uniprot Swissprot Chembl Description Number Shared
HDA10_HUMAN Q969S8 CHEMBL5103 Histone Deacetylase 10, Human 2
HDA11_HUMAN Q96DB2 CHEMBL3310 Histone Deacetylase 11, Human 2
HDA11_MOUSE Q91WA3 CHEMBL5143 Histone Deacetylase 11, Mouse 2
HDAC1_HUMAN Q13547 CHEMBL325 Histone Deacetylase 1, Human 2
HDAC1_MOUSE O09106 CHEMBL4001 Histone Deacetylase 1, Mouse 2
HDAC2_HUMAN Q92769 CHEMBL1937 Histone Deacetylase 2, Human 2
HDAC2_MOUSE P70288 CHEMBL4238 Histone Deacetylase 2, Mouse 2
HDAC3_HUMAN O15379 CHEMBL1829 Histone Deacetylase 3, Human 2
HDAC4_HUMAN P56524 CHEMBL3524 Histone Deacetylase 4, Human 2
HDAC5_HUMAN Q9UQL6 CHEMBL2563 Histone Deacetylase 5, Human 2
HDAC5_MOUSE Q9Z2V6 CHEMBL2768 Histone Deacetylase 5, Mouse 2
HDAC6_HUMAN Q9UBN7 CHEMBL1865 Histone Deacetylase 6, Human 2
HDAC6_MOUSE Q9Z2V5 CHEMBL2878 Histone Deacetylase 6, Mouse 2
HDAC7_HUMAN Q8WUI4 CHEMBL2716 Histone Deacetylase 7, Human 2
HDAC7_MOUSE Q8C2B3 CHEMBL4219 Histone Deacetylase 7, Mouse 2
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 2
HDAC8_MOUSE Q8VH37 CHEMBL2347 Histone Deacetylase 8, Mouse 2
HDAC9_HUMAN Q9UKV0 CHEMBL4145 Histone Deacetylase 9, Human 2
HDAC9_MOUSE Q99N13 CHEMBL5204 Histone Deacetylase 9, Mouse 2
B1WBY8_RAT B1WBY8 CHEMBL4705 Histone Deacetylase 2, Rat 1
HDAC1_RAT Q4QQW4 CHEMBL2915 Histone Deacetylase 1, Rat 1
HDAC3_RAT Q6P6W3 CHEMBL2628 Histone Deacetylase 3, Rat 1
HDAC4_RAT Q99P99 CHEMBL2874 Histone Deacetylase 4, Rat 1
HDAC7_RAT Q99P96 CHEMBL2914 Histone Deacetylase 7, Rat 1
HDAH_ALCSD Q70I53 CHEMBL6017 Histone Deacetylase-like Amidohydrolase, Alcsd 1
NCOR2_HUMAN Q9Y618 CHEMBL5949 Nuclear Receptor Corepressor 2, Human 1
Q5RJZ2_RAT Q5RJZ2 CHEMBL4025 Histone Deacetylase 5, Rat 1
Q94F81_MAIZE Q94F81 CHEMBL4919 Histone Deacetylase HD2, Maize 1
Q99P97_RAT Q99P97 CHEMBL3101 Histone Deacetylase 6, Rat 1
Q9XYC7_PLAFA Q9XYC7 CHEMBL5541 Histone Deacetylase, Plafa 1
Q9ZTP8_MAIZE Q9ZTP8 CHEMBL3541 Histone Deacetylase HD1B, Maize 1
SF3B3_HUMAN Q15393 CHEMBL1250378 Splicing Factor 3B Subunit 3, Human 1
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 1