UCSF

Arachidonate 5-lipoxygenase, Rat (1,236 Compounds)

Swissprot:
LOX5_RAT
Stitch:
LOX5_RAT
UniProt:
P12527
ChEMBL:
CHEMBL312
PDB:
Alox5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,236 82 35 22
Binding ≤ 1μM 739 42 17 8
Functional ≤ 10μM 366 33 12 9

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 952 85 36 16
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 57 11 1 1

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
LOX5-1-E Arachidonate 5-lipoxygenase (cluster #1 Of 6), Eukaryotic 1,382 99 38 23
LOX5-2-E Arachidonate 5-lipoxygenase (cluster #2 Of 6), Eukaryotic 64 8 6 2
LOX5-3-E Arachidonate 5-lipoxygenase (cluster #3 Of 6), Eukaryotic 17 1 0 0
LOX5-4-E Arachidonate 5-lipoxygenase (cluster #4 Of 6), Eukaryotic 260 19 8 5
LOX5-5-E Arachidonate 5-lipoxygenase (cluster #5 Of 6), Eukaryotic 119 11 4 0
LOX5-6-E Arachidonate 5-lipoxygenase (cluster #6 Of 6), Eukaryotic 309 24 8 4
Uniprot Swissprot Chembl Description Number Shared
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 210
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 183
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 183
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 48
CLTR2_HUMAN Q9NS75 CHEMBL4330 Cysteinyl Leukotriene Receptor 2, Human 45
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 44
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 43
LX12L_RAT Q02759 CHEMBL2741 Arachidonate 12-lipoxygenase, Rat 26
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 24
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 21
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 20
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 18
THAS_RAT P49430 CHEMBL4028 Thromboxane-A Synthase, Rat 17
Z50587 Z50587 CHEMBL372 Homo Sapiens 17
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 16
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 16
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 11
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 10
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 10
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 8
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 8
LX15B_RAT Q8K4F2 CHEMBL3289 Arachidonate 15-lipoxygenase, Type II, Rat 6
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 6
Z80419 Z80419 CHEMBL614772 RBL-1 (Basophilic Leukemia Cells) 6
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 5
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 5
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 5
PA21B_PIG P00592 CHEMBL4715 Phospholipase A2 Group 1B, Pig 5
Z50594 Z50594 CHEMBL375 Mus Musculus 5
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 4
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 4
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 4
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 4
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 4
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 4
Q9BEG3_BOVIN Q9BEG3 CHEMBL2980 Arachidonate 5-lipoxygenase, Bovin 4
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 3
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 3
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 3
Z100274 Z100274 CHEMBL614676 Liposome 3
Z100751 Z100751 CHEMBL613706 PMNL (Polymorphonuclear Leukocytes) 3
Z50512 Z50512 CHEMBL369 Cavia Porcellus 3
Z50588 Z50588 CHEMBL373 Canis Familiaris 3
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 3
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 3
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 2
LOX12_PIG P16469 CHEMBL2381 Arachidonate 12-lipoxygenase, Pig 2
PA21B_RAT P04055 CHEMBL5016 Phospholipase A2 Group 1B, Rat 2
PGH2_RABIT O02768 CHEMBL1293198 Prostaglandin G/H Synthase 2, Rabit 2
Q6UB75_PIG Q6UB75 CHEMBL3651 Group VII Phospholipase A2, Pig 2
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
HDAC8_HUMAN Q9BY41 CHEMBL3192 Histone Deacetylase 8, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 1
PDK2_HUMAN Q15119 CHEMBL3861 Pyruvate Dehydrogenase Kinase Isoform 2, Human 1
PDK3_HUMAN Q15120 CHEMBL3893 Pyruvate Dehydrogenase Kinase Isoform 3, Human 1
PDK4_HUMAN Q16654 CHEMBL4141 Pyruvate Dehydrogenase Kinase Isoform 4, Human 1
PGH1_RABIT O97554 CHEMBL3334 Cyclooxygenase-1, Rabit 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PTGDS_BOVIN O02853 CHEMBL4651 Prostaglandin D2 Synthase, Bovin 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1
Z102178 Z102178 CHEMBL613694 Liver Microsomes 1
Z102342 Z102342 CHEMBL613642 Liver 1
Z50507 Z50507 CHEMBL613115 Equus Caballus 1
Z80216 Z80216 CHEMBL614042 MAC13 1
Z80218 Z80218 CHEMBL614318 MAC16 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80420 Z80420 CHEMBL614632 RBL-2H3 (Basophilic Leukemia Cells) 1
Z81000 Z81000 CHEMBL614316 HT-22 (Hippocampal Cells) 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1

Most Common Rings