UCSF

Pyruvate Dehydrogenase Kinase Isoform 1, Human (134 Compounds)

Swissprot:
PDK1_HUMAN
Stitch:
PDK1_HUMAN
UniProt:
Q15118
ChEMBL:
CHEMBL4766
Reactome:
REACT_12528
PDB:
2Q8F (DOCK)
2Q8G (DOCK)
2Q8H (DOCK)
PDK1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 134 4 3 4
Binding ≤ 1μM 86 1 0 3
Functional ≤ 10μM 6 0 0 1

Reactome Network (1)

Reactome ID Description Species
REACT_12528 Regulation of pyruvate dehydrogenase (PDH) complex Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PDK2_HUMAN Q15119 CHEMBL3861 Pyruvate Dehydrogenase Kinase Isoform 2, Human 110
PDK3_HUMAN Q15120 CHEMBL3893 Pyruvate Dehydrogenase Kinase Isoform 3, Human 110
PDK4_HUMAN Q16654 CHEMBL4141 Pyruvate Dehydrogenase Kinase Isoform 4, Human 110
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDK1_RAT Q63065 CHEMBL2416 Pyruvate Dehydrogenase Kinase Isoform 1, Rat 48 2 0 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDK2_HUMAN Q15119 CHEMBL3861 Pyruvate Dehydrogenase Kinase Isoform 2, Human 110 2 2 1
PDK3_HUMAN Q15120 CHEMBL3893 Pyruvate Dehydrogenase Kinase Isoform 3, Human 110 2 2 1
PDK4_HUMAN Q16654 CHEMBL4141 Pyruvate Dehydrogenase Kinase Isoform 4, Human 110 2 2 1

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
PDK1-1-E Pyruvate Dehydrogenase Kinase Isoform 1 (cluster #1 Of 3), Eukaryotic 36 3 2 3
PDK1-2-E Pyruvate Dehydrogenase Kinase Isoform 1 (cluster #2 Of 3), Eukaryotic 5 1 1 0
PDK1-3-E Pyruvate Dehydrogenase Kinase Isoform 1 (cluster #3 Of 3), Eukaryotic 141 2 0 1
Uniprot Swissprot Chembl Description Number Shared
PDK2_HUMAN Q15119 CHEMBL3861 Pyruvate Dehydrogenase Kinase Isoform 2, Human 110
PDK3_HUMAN Q15120 CHEMBL3893 Pyruvate Dehydrogenase Kinase Isoform 3, Human 110
PDK4_HUMAN Q16654 CHEMBL4141 Pyruvate Dehydrogenase Kinase Isoform 4, Human 110
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 11
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 9
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 9
PDK1_RAT Q63065 CHEMBL2416 Pyruvate Dehydrogenase Kinase Isoform 1, Rat 8
PDK2_RAT Q64536 CHEMBL3601 Pyruvate Dehydrogenase Kinase Isoform 2, Rat 8
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 6
Z50587 Z50587 CHEMBL372 Homo Sapiens 6
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 5
ABCC8_HUMAN Q09428 CHEMBL2071 Sulfonylurea Receptor 1, Human 4
ABCC9_HUMAN O60706 CHEMBL1971 Sulfonylurea Receptor 2, Human 4
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 4
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 4
IRK11_HUMAN Q14654 CHEMBL1886 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Human 4
IRK8_HUMAN Q15842 CHEMBL4770 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 8, Human 4
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 4
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 4
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 4
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 4
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 4
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 3
MAPK2_HUMAN P49137 CHEMBL2208 MAP Kinase-activated Protein Kinase 2, Human 3
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 3
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 3
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 3
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 2
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 2
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 2
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 2
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 2
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 2
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 2
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 2
MAPK5_HUMAN Q8IW41 CHEMBL3094 MAP Kinase-activated Protein Kinase 5, Human 2
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 2
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 2
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 2
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 2
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 2
AAKB1_HUMAN Q9Y478 CHEMBL3847 AMP-activated Protein Kinase, Beta-1 Subunit, Human 1
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 1
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CDC7_HUMAN O00311 CHEMBL5443 Cell Division Cycle 7-related Protein Kinase, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 1
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 1
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 1
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
IRAK1_HUMAN P51617 CHEMBL3357 Interleukin-1 Receptor-associated Kinase 1, Human 1
JAK1_HUMAN P23458 CHEMBL2835 Tyrosine-protein Kinase JAK1, Human 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 1
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 1
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 1
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
KS6A3_HUMAN P51812 CHEMBL2345 Ribosomal Protein S6 Kinase Alpha 3, Human 1
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
MARK2_HUMAN Q7KZI7 CHEMBL3831 MAP/microtubule Affinity-regulating Kinase 2, Human 1
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
PAK1_HUMAN Q13153 CHEMBL4600 Serine/threonine-protein Kinase PAK 1, Human 1
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 1
PDPK1_HUMAN O15530 CHEMBL2534 3-phosphoinositide Dependent Protein Kinase-1, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 1
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 1
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 1
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 1
SGK1_HUMAN O00141 CHEMBL2343 Serine/threonine-protein Kinase Sgk1, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
SRPK1_HUMAN Q96SB4 CHEMBL4375 Serine/threonine-protein Kinase SRPK1, Human 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1
TOPK_HUMAN Q96KB5 CHEMBL4896 PDZ-binding Kinase, Human 1
TYK2_HUMAN P29597 CHEMBL3553 Tyrosine-protein Kinase TYK2, Human 1
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 1
Z50512 Z50512 CHEMBL369 Cavia Porcellus 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1

Most Common Rings