UCSF

Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Human (96 Compounds)

Swissprot:
IRK11_HUMAN
Stitch:
IRK11_HUMAN
UniProt:
Q14654
ChEMBL:
CHEMBL1886
Reactome:
REACT_75775
REACT_18325
PDB:
KCNJ11

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 96 11 5 6
Binding ≤ 1μM 71 11 5 6
Functional ≤ 10μM 144 5 2 3

Reactome Network (2)

Reactome ID Description Species
REACT_75775 ATP sensitive Potassium channels Homo sapiens
REACT_18325 Regulation of insulin secretion Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ABCC8_HUMAN Q09428 CHEMBL2071 Sulfonylurea Receptor 1, Human 171
ABCC9_HUMAN O60706 CHEMBL1971 Sulfonylurea Receptor 2, Human 161
IRK8_HUMAN Q15842 CHEMBL4770 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 8, Human 144

Regulation of insulin secretion

Uniprot Swissprot Chembl Description Number Shared
ABCC8_HUMAN Q09428 CHEMBL2071 Sulfonylurea Receptor 1, Human 171
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
IRK11_RAT P70673 CHEMBL3704 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Rat 3 2 2 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
IRK8_HUMAN Q15842 CHEMBL4770 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 8, Human 22 4 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
IRK11-1-E Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11 (cluster #1 Of 2), Eukaryotic 82 8 3 4
IRK11-2-E Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11 (cluster #2 Of 2), Eukaryotic 16 4 3 3
Uniprot Swissprot Chembl Description Number Shared
ABCC8_HUMAN Q09428 CHEMBL2071 Sulfonylurea Receptor 1, Human 171
ABCC9_HUMAN O60706 CHEMBL1971 Sulfonylurea Receptor 2, Human 161
IRK8_HUMAN Q15842 CHEMBL4770 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 8, Human 144
Z50512 Z50512 CHEMBL369 Cavia Porcellus 77
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 13
Z80047 Z80047 CHEMBL614063 Beta-TC3 (Insulinoma Cells) 5
Z80700 Z80700 CHEMBL614357 Beta-TC6 (Pancreatic Insulinoma Cells) 5
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 5
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 4
PDK2_HUMAN Q15119 CHEMBL3861 Pyruvate Dehydrogenase Kinase Isoform 2, Human 4
PDK3_HUMAN Q15120 CHEMBL3893 Pyruvate Dehydrogenase Kinase Isoform 3, Human 4
PDK4_HUMAN Q16654 CHEMBL4141 Pyruvate Dehydrogenase Kinase Isoform 4, Human 4
KCND3_HUMAN Q9UK17 CHEMBL1964 Voltage-gated Potassium Channel Subunit Kv4.3, Human 2
Z50587 Z50587 CHEMBL372 Homo Sapiens 2
ABCC9_RAT Q63563 CHEMBL3244 Sulfonylurea Receptor 2, Rat 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPC_ENTCL P05364 CHEMBL2725 Beta-lactamase, Entcl 1
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 1
IRK11_RAT P70673 CHEMBL3704 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Rat 1
IRK8_RAT Q63664 CHEMBL4293 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 8, Rat 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
Z102306 Z102306 CHEMBL613606 Aorta 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1