UCSF

HEK293 (Embryonic Kidney Fibroblasts) (3 Compounds)

Swissprot:
Z80936
Stitch:
Z80936
UniProt:
Z80936
ChEMBL:
CHEMBL614818

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 3 0 0 0
Binding ≤ 1μM 2 0 0 0
Functional ≤ 10μM 414 34 13 17
ADME/T ≤ 10μM 86 15 13 10

Reactome Network (0)

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 34
Z80414 Z80414 CHEMBL614628 Raji (B-lymphoblastic Cells) 33
Z80704 Z80704 CHEMBL614358 BJ (Foreskin Fibroblast Cells) 28
Z80214 Z80214 CHEMBL614317 M14 (Melanoma Cells) 21
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 19
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 14
Z80433 Z80433 CHEMBL614882 RPMI-8226 (Multiple Myeloma Cells) 14
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 13
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 13
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 13
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 12
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 12
Z104292 Z104292 CHEMBL1907598 Integrin Alpha-V/beta-3 12
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 11
KCNQ2_MOUSE Q9Z351 CHEMBL2985 Voltage-gated Potassium Channel Subunit Kv7.2, Mouse 10
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 9
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 9
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 9
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 8
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 8
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 7
GYS1_HUMAN P13807 CHEMBL4000 Muscle Glycogen Synthase, Human 7
Z80013 Z80013 CHEMBL614513 A10 7
Z80140 Z80140 CHEMBL614570 GBM 7
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 7
Z80178 Z80178 CHEMBL614040 J774.A1 (Macrophage Cells) 7
Z80700 Z80700 CHEMBL614357 Beta-TC6 (Pancreatic Insulinoma Cells) 7
Z81186 Z81186 CHEMBL614097 LS174T (Colon Adencocarcinoma Cells) 7
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 6
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 6
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 6
ABCC8_HUMAN Q09428 CHEMBL2071 Sulfonylurea Receptor 1, Human 5
IRK11_HUMAN Q14654 CHEMBL1886 Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Human 5
Z80035 Z80035 CHEMBL381 B16 (Melanoma Cells) 5
Z80047 Z80047 CHEMBL614063 Beta-TC3 (Insulinoma Cells) 5
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 5
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 5
Z81011 Z81011 CHEMBL614840 Human Cell Lines 5
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 5
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 4
PTGR1_RAT P97584 CHEMBL4166 NADP-dependent Leukotriene B4 12-hydroxydehydrogenase, Rat 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 4
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 4
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 4
Z80169 Z80169 CHEMBL614039 Huh-7 (Hepatocellular Carcinoma) 4
Z81244 Z81244 CHEMBL614123 J774 (Macrophage Cells) 4
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 4
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 4
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 3
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 3
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 3
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 3
PSN1_HUMAN P49768 CHEMBL2473 Presenilin 1, Human 3
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 3
TLR4_HUMAN O00206 CHEMBL5255 Toll-like Receptor 4, Human 3
Z103203 Z103203 CHEMBL1075388 A375 3
Z50594 Z50594 CHEMBL375 Mus Musculus 3
Z80002 Z80002 CHEMBL614075 1A9 (Ovarian Adenocarcinoma Cells) 3
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 3
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 3
Z80068 Z80068 CHEMBL614542 CCRF-SB (Lymphoblastic Leukemia Cells) 3
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 3
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 3
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 3
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 3
Z80211 Z80211 CHEMBL614721 LoVo (Colon Adenocarcinoma Cells) 3
Z80295 Z80295 CHEMBL388 MT4 (Lymphocytes) 3
Z80354 Z80354 CHEMBL614213 OVCAR-3 (Ovarian Adenocarcinoma Cells) 3
Z80362 Z80362 CHEMBL389 P388 (Lymphoma Cells) 3
Z80471 Z80471 CHEMBL614910 SH-SY5 (Bone Marrow Neuroblastoma Cells) 3
Z80697 Z80697 CHEMBL614279 Bel-7402 (Hepatoma Cells) 3
Z80819 Z80819 CHEMBL614484 J774.2 3
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 3
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 3
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 3
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 2
APH1A_MOUSE Q8BVF7 CHEMBL3787 Gamma-secretase Subunit APH-1A, Mouse 2
APH1B_MOUSE Q8C7N7 CHEMBL3786 Gamma-secretase Subunit APH-1B, Mouse 2
CP2B6_HUMAN P20813 CHEMBL4729 Cytochrome P450 2B6, Human 2
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 2
MC3R_HUMAN P41968 CHEMBL4644 Melanocortin Receptor 3, Human 2
MC5R_HUMAN P33032 CHEMBL4608 Melanocortin Receptor 5, Human 2
NICA_MOUSE P57716 CHEMBL4548 Nicastrin, Mouse 2
PEN2_MOUSE Q9CQR7 CHEMBL4539 Gamma-secretase Subunit PEN-2, Mouse 2
PSN1_MOUSE P49769 CHEMBL5128 Presenilin-1, Mouse 2
PSN2_MOUSE Q61144 CHEMBL3483 Presenilin-2, Mouse 2
TOP1_HUMAN P11387 CHEMBL1781 DNA Topoisomerase I, Human 2
TOP1_MOUSE Q04750 CHEMBL2814 DNA Topoisomerase I, Mouse 2
TOP2A_HUMAN P11388 CHEMBL1806 DNA Topoisomerase II Alpha, Human 2
TOP2A_MOUSE Q01320 CHEMBL3586 DNA Topoisomerase II Alpha, Mouse 2
TOP2B_HUMAN Q02880 CHEMBL3396 DNA Topoisomerase II Beta, Human 2
TOP2B_MOUSE Q64511 CHEMBL5564 DNA Topoisomerase II Beta, Mouse 2
Z103205 Z103205 CHEMBL1075390 A431 2
Z103219 Z103219 CHEMBL1075404 Ca9-22 2
Z50347 Z50347 CHEMBL361 Saccharomyces Cerevisiae 2
Z50587 Z50587 CHEMBL372 Homo Sapiens 2
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 2
Z80005 Z80005 CHEMBL614077 3T3 (Fibroblast Cells) 2
Z80008 Z80008 CHEMBL612565 5637 (Epithelial Bladder Carcinoma Cells) 2
Z80017 Z80017 CHEMBL614023 A2780cisR (Cisplatin-resistant Ovarian Carcinoma Cells) 2
Z80018 Z80018 CHEMBL613859 A-375 (Malignant Melanoma Cells) 2
Z80021 Z80021 CHEMBL614516 A498 (Renal Carcinoma Cells) 2
Z80025 Z80025 CHEMBL614519 ACHN (Renal Adenocarcinoma Cells) 2
Z80026 Z80026 CHEMBL613860 AGS (Gastric Adenocarcinoma Cells) 2
Z80039 Z80039 CHEMBL614526 BGC-823 (Stomach Adenocarcinoma Cells) 2
Z80052 Z80052 CHEMBL614533 C8166 (Leukemic T-cells) 2
Z80092 Z80092 CHEMBL614031 CHO-K1 (Ovarian Cells) 2
Z80105 Z80105 CHEMBL613854 COR-L23 (Lung Carcinoma Cells) 2
Z80114 Z80114 CHEMBL614281 Daudi (Burkitts Lymphoma Cells) 2
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 2
Z80126 Z80126 CHEMBL614289 DuPro 2
Z80138 Z80138 CHEMBL614036 G-361 (Melanoma Cells) 2
Z80145 Z80145 CHEMBL614045 H69 2
Z80175 Z80175 CHEMBL614585 IMR-32 (Neuroblastoma Cells) 2
Z80188 Z80188 CHEMBL614590 KB 3-1 (Cervical Epithelial Carcinoma Cells) 2
Z80227 Z80227 CHEMBL614324 MCF7-ADR (Breast Carcinoma Cells) 2
Z80240 Z80240 CHEMBL614129 MDA-MB-361 2
Z80243 Z80243 CHEMBL614334 MDA-MB-453 (Breast Adenocarcinoma Cells) 2
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 2
Z80253 Z80253 CHEMBL614342 MEF (Embryonic Fibroblast Cells) 2
Z80254 Z80254 CHEMBL614343 MES-SA (Uterine Sarcoma Cells) 2
Z80255 Z80255 CHEMBL613827 MES-SA/DxS (Uterine Sarcoma Cells) 2
Z80267 Z80267 CHEMBL614352 MKN-1 2
Z80269 Z80269 CHEMBL614354 MKN-45 (Gastric Adenocarcinoma Cells) 2
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 2
Z80291 Z80291 CHEMBL614181 MRC5 (Embryonic Lung Fibroblast Cells) 2
Z80322 Z80322 CHEMBL614135 NCI-H358 (Lung Carcinama Cells) 2
Z80330 Z80330 CHEMBL614197 NCI-N87 2
Z80364 Z80364 CHEMBL614218 P388/ADR (Lymphoma Cells) 2
Z80367 Z80367 CHEMBL614220 P388/S 2
Z80389 Z80389 CHEMBL614140 PC-14 2
Z80441 Z80441 CHEMBL614889 RXF 944 2
Z80466 Z80466 CHEMBL614907 SF268 2
Z80468 Z80468 CHEMBL614908 SF-295 (Glioblastoma Cells) 2
Z80472 Z80472 CHEMBL612542 SiHa (Cervical Squamous Cell Carcinoma) 2
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 2
Z80477 Z80477 CHEMBL614912 SK_HEP1 (Hepatoma Cells) 2
Z80479 Z80479 CHEMBL614914 SK-MEL (Melanoma Cells) 2
Z80481 Z80481 CHEMBL614916 SK-MEL-1 (Metastatic Melanoma Cells) 2
Z80482 Z80482 CHEMBL614917 SK-MEL-2 (Melanoma Cells) 2
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 2
Z80490 Z80490 CHEMBL614923 SK-MES-1 2
Z80491 Z80491 CHEMBL614163 SK-N-MC (Neuroepithelioma Cells) 2
Z80492 Z80492 CHEMBL614924 SK-N-SH (Neuroblastoma Cells) 2
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 2
Z80495 Z80495 CHEMBL614927 SK-VLB 2
Z80503 Z80503 CHEMBL614931 SNU1 2
Z80509 Z80509 CHEMBL614935 SNU-638 (Gastric Carcinoma Cells) 2
Z80526 Z80526 CHEMBL612544 SW480 (Colon Adenocarcinoma Cells) 2
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 2
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 2
Z80559 Z80559 CHEMBL615021 U251 2
Z80560 Z80560 CHEMBL615022 U-251 (Glioma Cells) 2
Z80563 Z80563 CHEMBL615025 U-373 MG ( Glioblastoma Cells) 2
Z80565 Z80565 CHEMBL614247 U-87 MG (Glioblastoma Cells) 2
Z80574 Z80574 CHEMBL612799 UMUC3 2
Z80581 Z80581 CHEMBL614248 VA13 2
Z80583 Z80583 CHEMBL391 Vero (Kidney Cells) 2
Z80595 Z80595 CHEMBL612810 WIL2-NS (Lymphoblastoid Cells) 2
Z80600 Z80600 CHEMBL613533 XF498 (Glioma Cells) 2
Z80608 Z80608 CHEMBL614393 ZR-75-1 (Breast Carcinoma Cells) 2
Z80661 Z80661 CHEMBL614567 A704 (Renal Carcinoma Cells) 2
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 2
Z80726 Z80726 CHEMBL614367 TRAMP-C1A (Prostate Carcinoma Cells) 2
Z80730 Z80730 CHEMBL614368 C2D Cell Line 2
Z80731 Z80731 CHEMBL613541 C2G Cell Line 2
Z80732 Z80732 CHEMBL614369 TRAMP-C2H (Prostate Carcinoma Cells) 2
Z80735 Z80735 CHEMBL614739 C38 (Colon Carcinoma) 2
Z80762 Z80762 CHEMBL613843 BP8 (Ascites Sarcoma Cells) 2
Z80768 Z80768 CHEMBL614455 CH1 (Ovarian Carcinoma Cells) 2
Z80784 Z80784 CHEMBL614462 Col2 (Colon Carcinoma Cells) 2
Z80801 Z80801 CHEMBL614151 CRL-7065 Cell Line 2
Z80846 Z80846 CHEMBL614493 F460pv8/eto Cell Line 2
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 2
Z80887 Z80887 CHEMBL614802 H2981 Cell Line 2
Z80889 Z80889 CHEMBL614803 NCI-H322M (Non-small Cell Lung Carcinoma Cells) 2
Z80896 Z80896 CHEMBL614805 NCI-H69 (Small Cell Lung Carcinoma Cells) 2
Z80943 Z80943 CHEMBL614819 HEL 299 2
Z80945 Z80945 CHEMBL614735 HEp-2 (Laryngeal Carcinoma Cells) 2
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 2
Z81005 Z81005 CHEMBL614839 HTB-54 Cell Line 2
Z81006 Z81006 CHEMBL612259 Human Breast 401NL Tumor Cell Line 2
Z81017 Z81017 CHEMBL614647 WiDr (Colon Adenocarcinoma Cells) 2
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 2
Z81025 Z81025 CHEMBL613890 Human Lung LXF 529L Tumor Cell Line 2
Z81026 Z81026 CHEMBL614689 Human Lung LXF 629L Tumor Cell Line 2
Z81028 Z81028 CHEMBL613892 Human Melanoma Cell Line 2
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 2
Z81043 Z81043 CHEMBL613969 N592 2
Z81054 Z81054 CHEMBL613977 SF-268 (Glioblastoma Cells) 2
Z81101 Z81101 CHEMBL614010 KBM-3 Cell Line 2
Z81102 Z81102 CHEMBL613994 KBM-3/DOX Cell Line 2
Z81133 Z81133 CHEMBL614000 L1210 (1565) 2
Z81134 Z81134 CHEMBL614650 L2987 (Lung Adenocarcinoma Cells) 2
Z81160 Z81160 CHEMBL614088 Lewis Lung Carcinoma Cell Line 2
Z81164 Z81164 CHEMBL614091 LL Cell Line 2
Z81167 Z81167 CHEMBL614093 LLTC Cell Line 2
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 2
Z81184 Z81184 CHEMBL614096 LOX IMVI (Melanoma Cells) 2
Z81201 Z81201 CHEMBL614643 HOP-62 (Non-small Cell Lung Carcinoma Cells) 2
Z81211 Z81211 CHEMBL614109 LXFL529 Cell Line 2
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 2
Z81257 Z81257 CHEMBL614732 MEL-AC Cell Line 2
Z81261 Z81261 CHEMBL614127 UACC-375 2
Z81277 Z81277 CHEMBL613287 NCI-N417 2
Z81280 Z81280 CHEMBL614740 NCI-H226 (Non-small Cell Lung Carcinoma Cells) 2
Z81284 Z81284 CHEMBL614999 NCI-H647 2
Z81341 Z81341 CHEMBL614310 Tumor Cell Lines 2
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
ADO_HUMAN Q06278 CHEMBL3257 Aldehyde Oxidase, Human 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
CASR_HUMAN P41180 CHEMBL1878 Calcium Sensing Receptor, Human 1
CASR_RAT P48442 CHEMBL2516 Calcium Sensing Receptor, Rat 1
CRFR1_HUMAN P34998 CHEMBL1800 Corticotropin Releasing Factor Receptor 1, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
KCNQ2_HUMAN O43526 CHEMBL2476 Voltage-gated Potassium Channel Subunit Kv7.2, Human 1
KCNQ3_HUMAN O43525 CHEMBL2684 Voltage-gated Potassium Channel Subunit Kv7.3, Human 1
KCNQ5_HUMAN Q9NR82 CHEMBL2925 Voltage-gated Potassium Channel Subunit Kv7.5, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
Q862F3_BOVIN Q862F3 CHEMBL4262 Tubulin Alpha Chain, Bovin 1
Q862L2_BOVIN Q862L2 CHEMBL3752 Tubulin Alpha-1 Chain, Bovin 1
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 1
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 1
TBB2B_BOVIN Q6B856 CHEMBL3394 Tubulin Beta Chain, Bovin 1
Z100201 Z100201 CHEMBL612422 Splenocytes (Spleen Cells) 1
Z100695 Z100695 CHEMBL612587 WRL68 (Embryonic Hepatoma Cells) 1
Z101973 Z101973 CHEMBL613240 Paracentrotus Lividus 1
Z102213 Z102213 CHEMBL613416 Blood 1
Z103196 Z103196 CHEMBL1075381 22RV1 1
Z50420 Z50420 CHEMBL612851 Trypanosoma Brucei Brucei 1
Z50426 Z50426 CHEMBL612856 Plasmodium Falciparum (isolate K1 / Thailand) 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50512 Z50512 CHEMBL369 Cavia Porcellus 1
Z50602 Z50602 CHEMBL377 Human Herpesvirus 1 1
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 1
Z50651 Z50651 CHEMBL613739 Vesicular Stomatitis Virus 1
Z80110 Z80110 CHEMBL613507 CV-1 (Kidney Cells) 1
Z80121 Z80121 CHEMBL614286 DMS-79 (Small Cell Lung Carcinoma Cells) 1
Z80284 Z80284 CHEMBL614176 MOLT-3 (T-lymphoblastic Leukemia Cells) 1
Z80427 Z80427 CHEMBL614879 RKO (Colon Carcinoma) 1
Z80561 Z80561 CHEMBL615023 U2OS (Osteosarcoma Cells) 1
Z80640 Z80640 CHEMBL613102 786-0 (Renal Carcinoma Cells) 1
Z80761 Z80761 CHEMBL614453 AhR+/+5L (Hepatoma Cells) 1
Z80800 Z80800 CHEMBL614725 MIA PaCa-2 (Pancreatic Carcinoma Cells) 1
Z80847 Z80847 CHEMBL612250 FaDu (Pharyngeal Carcinoma Cells) 1
Z80866 Z80866 CHEMBL612707 GLC4 Cell Line 1
Z81068 Z81068 CHEMBL614649 Ishikawa (Uterine Carcinoma Cells) 1
Z81135 Z81135 CHEMBL614793 L6 (Skeletal Muscle Myoblast Cells) 1