UCSF

Nicastrin, Human (246 Compounds)

Swissprot:
NICA_HUMAN
Stitch:
NICA_HUMAN
UniProt:
Q92542
ChEMBL:
CHEMBL3418
Reactome:
REACT_118614
REACT_160254
REACT_160243
REACT_118572
REACT_228189
REACT_160205
REACT_13643
REACT_116022
REACT_13443
REACT_118862
REACT_118636
PDB:
NCSTN

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 246 0 0 0
Binding ≤ 1μM 191 0 0 0
Functional ≤ 10μM 142 2 0 0
Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
PSN1_HUMAN P49768 CHEMBL2473 Presenilin 1, Human 384

EPH-ephrin mediated repulsion of cells

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

NOTCH2 Activation and Transmission of Signal to the Nucleus

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

NRIF signals cell death from the nucleus

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Nuclear signaling by ERBB4

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Regulated proteolysis of p75NTR

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Signaling by NOTCH3

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Signaling by NOTCH4

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 384
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 384
PSN1_HUMAN P49768 CHEMBL2473 Presenilin 1, Human 384
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 384
APH1B_HUMAN Q8WW43 CHEMBL2385 Gamma-secretase Subunit APH-1B, Human 315
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 3
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 3