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ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (246)
Reactome (11)
Related By:
Pathway (13)
Organism (0)
Gene (0)
Org. Clust. (0)
ChEMBL (7)
Rings (2)

Nicastrin, Human (246 Compounds)

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	246	0	0	0
Binding ≤ 1μM	191	0	0	0
Functional ≤ 10μM	142	2	0	0

Reactome ID	Description	Species
REACT_118614	Activated NOTCH1 Transmits Signal to the Nucleus	Homo sapiens
REACT_160254	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Homo sapiens
REACT_160243	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Homo sapiens
REACT_118572	Degradation of the extracellular matrix	Homo sapiens
REACT_228189	EPH-ephrin mediated repulsion of cells	Homo sapiens
REACT_160205	NOTCH2 Activation and Transmission of Signal to the Nucleus	Homo sapiens
REACT_13643	NRIF signals cell death from the nucleus	Homo sapiens
REACT_116022	Nuclear signaling by ERBB4	Homo sapiens
REACT_13443	Regulated proteolysis of p75NTR	Homo sapiens
REACT_118862	Signaling by NOTCH3	Homo sapiens
REACT_118636	Signaling by NOTCH4	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
PSN1_HUMAN	P49768	CHEMBL2473	Presenilin 1, Human	384

EPH-ephrin mediated repulsion of cells

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

NOTCH2 Activation and Transmission of Signal to the Nucleus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

NRIF signals cell death from the nucleus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Nuclear signaling by ERBB4

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Regulated proteolysis of p75NTR

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Signaling by NOTCH3

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Signaling by NOTCH4

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	384
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	384
PSN1_HUMAN	P49768	CHEMBL2473	Presenilin 1, Human	384
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	384
APH1B_HUMAN	Q8WW43	CHEMBL2385	Gamma-secretase Subunit APH-1B, Human	315
BACE1_HUMAN	P56817	CHEMBL4822	Beta-secretase 1, Human	3
Z80936	Z80936	CHEMBL614818	HEK293 (Embryonic Kidney Fibroblasts)	3

Synonyms
Compounds (246)
Related By:
Pathway (13)
Organism (0)
Gene (0)
ChEMBL (7)
Org. Clust. (0)
Rings (2)