UCSF

Gamma-secretase Subunit APH-1B, Human (277 Compounds)

Swissprot:
APH1B_HUMAN
Stitch:
APH1B_HUMAN
UniProt:
Q8WW43
ChEMBL:
CHEMBL2385
Reactome:
REACT_118614
REACT_160254
REACT_160243
REACT_228189
REACT_160205
REACT_13643
REACT_116022
REACT_13443
REACT_118862
REACT_118636
PDB:
APH1B

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 277 3 0 0
Binding ≤ 1μM 225 3 0 0
Functional ≤ 10μM 142 2 0 0
Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

EPH-ephrin mediated repulsion of cells

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

NOTCH2 Activation and Transmission of Signal to the Nucleus

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

NRIF signals cell death from the nucleus

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Nuclear signaling by ERBB4

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Regulated proteolysis of p75NTR

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Signaling by NOTCH3

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Signaling by NOTCH4

Uniprot Swissprot Chembl Description Number Shared
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 415
APH1A_HUMAN Q96BI3 CHEMBL2362 Gamma-secretase Subunit APH-1A, Human 347
NICA_HUMAN Q92542 CHEMBL3418 Nicastrin, Human 315
PSN1_HUMAN P49768 CHEMBL2473 Presenilin 1, Human 315
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 315
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 3
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 3