UCSF

ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (277)
Reactome (10)
Related By:
Pathway (12)
Organism (0)
Gene (0)
Org. Clust. (0)
ChEMBL (7)
Rings (2)

Gamma-secretase Subunit APH-1B, Human (277 Compounds)

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	277	3	0	0
Binding ≤ 1μM	225	3	0	0
Functional ≤ 10μM	142	2	0	0

Reactome ID	Description	Species
REACT_118614	Activated NOTCH1 Transmits Signal to the Nucleus	Homo sapiens
REACT_160254	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Homo sapiens
REACT_160243	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Homo sapiens
REACT_228189	EPH-ephrin mediated repulsion of cells	Homo sapiens
REACT_160205	NOTCH2 Activation and Transmission of Signal to the Nucleus	Homo sapiens
REACT_13643	NRIF signals cell death from the nucleus	Homo sapiens
REACT_116022	Nuclear signaling by ERBB4	Homo sapiens
REACT_13443	Regulated proteolysis of p75NTR	Homo sapiens
REACT_118862	Signaling by NOTCH3	Homo sapiens
REACT_118636	Signaling by NOTCH4	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

EPH-ephrin mediated repulsion of cells

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

NOTCH2 Activation and Transmission of Signal to the Nucleus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

NRIF signals cell death from the nucleus

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Nuclear signaling by ERBB4

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Regulated proteolysis of p75NTR

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Signaling by NOTCH3

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Signaling by NOTCH4

Uniprot	Swissprot	Chembl	Description	Number Shared
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
PEN2_HUMAN	Q9NZ42	CHEMBL2374	Gamma-secretase Subunit PEN-2, Human	415
APH1A_HUMAN	Q96BI3	CHEMBL2362	Gamma-secretase Subunit APH-1A, Human	347
NICA_HUMAN	Q92542	CHEMBL3418	Nicastrin, Human	315
PSN1_HUMAN	P49768	CHEMBL2473	Presenilin 1, Human	315
PSN2_HUMAN	P49810	CHEMBL3708	Presenilin 2, Human	315
BACE1_HUMAN	P56817	CHEMBL4822	Beta-secretase 1, Human	3
Z80936	Z80936	CHEMBL614818	HEK293 (Embryonic Kidney Fibroblasts)	3

Synonyms
Compounds (277)
Related By:
Pathway (12)
Organism (0)
Gene (0)
ChEMBL (7)
Org. Clust. (0)
Rings (2)