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TLR4_HUMAN - Toll-like Receptor 4, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Toll-like Receptor 4, Human (8 Compounds)

Swissprot:
TLR4_HUMAN
Stitch:
TLR4_HUMAN
UniProt:
O00206
ChEMBL:
CHEMBL5255
Reactome:
REACT_25148
REACT_25374
REACT_6809
REACT_6788
REACT_6894
REACT_25351
REACT_150361
PDB:
2Z62 (DOCK)
2Z63 (DOCK)
2Z65 (DOCK)
2Z66 (DOCK)
3FXI (DOCK)
TLR4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 1 0 1
Binding ≤ 1μM 8 1 0 1
Functional ≤ 10μM 4 0 0 0

Reactome Network (7)

Reactome ID Description Species
REACT_25148 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Homo sapiens
REACT_25374 IKK complex recruitment mediated by RIP1 Homo sapiens
REACT_6809 MyD88-independent cascade Homo sapiens
REACT_6788 MyD88:Mal cascade initiated on plasma membrane Homo sapiens
REACT_6894 Toll Like Receptor 4 (TLR4) Cascade Homo sapiens
REACT_25351 TRAF6 mediated induction of TAK1 complex Homo sapiens
REACT_150361 TRIF-mediated programmed cell death Homo sapiens
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TLR2_HUMAN O60603 CHEMBL4163 Toll-like Receptor 2, Human 2 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
Z80178 Z80178 CHEMBL614040 J774.A1 (Macrophage Cells) 3
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 3