| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 8 | 1 | 0 | 1 |
| Binding ≤ 1μM | 8 | 1 | 0 | 1 |
| Functional ≤ 10μM | 4 | 0 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_25148 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | Homo sapiens |
| REACT_25374 | IKK complex recruitment mediated by RIP1 | Homo sapiens |
| REACT_6809 | MyD88-independent cascade | Homo sapiens |
| REACT_6788 | MyD88:Mal cascade initiated on plasma membrane | Homo sapiens |
| REACT_6894 | Toll Like Receptor 4 (TLR4) Cascade | Homo sapiens |
| REACT_25351 | TRAF6 mediated induction of TAK1 complex | Homo sapiens |
| REACT_150361 | TRIF-mediated programmed cell death | Homo sapiens |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| TLR2_HUMAN | O60603 | CHEMBL4163 | Toll-like Receptor 2, Human | 2 | 0 | 0 | 0 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| Z80178 | Z80178 | CHEMBL614040 | J774.A1 (Macrophage Cells) | 3 |
| Z80936 | Z80936 | CHEMBL614818 | HEK293 (Embryonic Kidney Fibroblasts) | 3 |