UCSF

P-glycoprotein 3, Mouse (72 Compounds)

Swissprot:
MDR3_MOUSE
Stitch:
MDR3_MOUSE
UniProt:
P21447
ChEMBL:
CHEMBL2573
Reactome:
REACT_196555
REACT_237882
PDB:
3G5U (DOCK)
3G60 (DOCK)
3G61 (DOCK)
Abcb4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 72 13 12 3
Binding ≤ 1μM 30 0 0 0
Functional ≤ 10μM 13 12 12 13

Reactome Network (2)

Reactome ID Description Species
REACT_196555 Abacavir transmembrane transport Mus musculus
REACT_237882 ABC-family proteins mediated transport Mus musculus
Uniprot Swissprot Chembl Description Number Shared
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 18

ABC-family proteins mediated transport

Uniprot Swissprot Chembl Description Number Shared
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 18
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 25 2 3 1
MDR2_MOUSE P21440 CHEMBL2837 P-glycoprotein 2, Mouse 7 2 3 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
MDR3-1-E P-glycoprotein 3 (cluster #1 Of 2), Eukaryotic 14 8 7 3
MDR3-2-E P-glycoprotein 3 (cluster #2 Of 2), Eukaryotic 58 5 5 0
Uniprot Swissprot Chembl Description Number Shared
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 37
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 18
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 13
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 8
MDR2_MOUSE P21440 CHEMBL2837 P-glycoprotein 2, Mouse 7
Z102121 Z102121 CHEMBL613162 Trichophyton Mentagrophytes 5
Z50408 Z50408 CHEMBL612841 Issatchenkia Orientalis 5
Z50442 Z50442 CHEMBL366 Candida Albicans 5
Z50443 Z50443 CHEMBL612647 Candida Glabrata 5
Z50452 Z50452 CHEMBL612649 Trichophyton Rubrum 5
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 4
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 4
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 4
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 4
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 4
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 4
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 4
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 4
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 4
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 4
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 4
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 4
Z50046 Z50046 CHEMBL612334 Trichophyton Quinckeanum 4
Z50409 Z50409 CHEMBL612842 Kluyveromyces Marxianus 4
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 4
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 3
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 3
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 3
Z50038 Z50038 CHEMBL612328 Plasmodium Yoelii Yoelii 3
Z50416 Z50416 CHEMBL363 Aspergillus Fumigatus 3
Z50459 Z50459 CHEMBL367 Leishmania Donovani 3
GRM6_HUMAN O15303 CHEMBL4573 Metabotropic Glutamate Receptor 6, Human 2
TRPA1_MOUSE Q8BLA8 CHEMBL1075310 Transient Receptor Potential Cation Channel Subfamily A Member 1, Mouse 2
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 2
Z50590 Z50590 CHEMBL613488 Sus Scrofa 2
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 1
CHLE_HUMAN P06276 CHEMBL1914 Butyrylcholinesterase, Human 1
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 1
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 1
Z50274 Z50274 CHEMBL614955 Aspergillus Flavus 1
Z50275 Z50275 CHEMBL358 Aspergillus Niger 1
Z50380 Z50380 CHEMBL613088 Mycobacterium Smegmatis 1
Z50426 Z50426 CHEMBL612856 Plasmodium Falciparum (isolate K1 / Thailand) 1
Z50436 Z50436 CHEMBL365 Filobasidiella Neoformans 1
Z50444 Z50444 CHEMBL612868 Candida Parapsilosis 1
Z50446 Z50446 CHEMBL612870 Candida Tropicalis 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50512 Z50512 CHEMBL369 Cavia Porcellus 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 1
Z50609 Z50609 CHEMBL613499 Simian Immunodeficiency Virus 1
Z50658 Z50658 CHEMBL380 Human Immunodeficiency Virus 2 1
Z50677 Z50677 CHEMBL613758 Human Immunodeficiency Virus 1
Z80107 Z80107 CHEMBL614564 COS-7 (Kidney Cells) 1
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 1
Z80133 Z80133 CHEMBL614294 EMT6 (Mammary Carcinoma Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80232 Z80232 CHEMBL614128 MCF7-VP 1
Z80295 Z80295 CHEMBL388 MT4 (Lymphocytes) 1
Z80362 Z80362 CHEMBL389 P388 (Lymphoma Cells) 1
Z80364 Z80364 CHEMBL614218 P388/ADR (Lymphoma Cells) 1
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 1
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 1
Z80711 Z80711 CHEMBL613829 NCI/ADR-RES (Breast Carcinoma Cells) 1
Z80773 Z80773 CHEMBL614456 CHRC/5 Cell Line 1
Z80774 Z80774 CHEMBL614457 CHRC5 Cell Line 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 1
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 1
Z81008 Z81008 CHEMBL614788 Human Breast Cancer Cell Lines 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1