UCSF

ATP-binding Cassette Sub-family G Member 2, Human (83 Compounds)

Swissprot:
ABCG2_HUMAN
Stitch:
ABCG2_HUMAN
UniProt:
Q9UNQ0
ChEMBL:
CHEMBL5393
Reactome:
REACT_120801
REACT_25060
PDB:
ABCG2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 83 30 35 9
Binding ≤ 1μM 26 4 5 2

Reactome Network (2)

Reactome ID Description Species
REACT_120801 Abacavir transmembrane transport Homo sapiens
REACT_25060 Iron uptake and transport Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 9

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ABCG2-1-E ATP-binding Cassette Sub-family G Member 2 (cluster #1 Of 2), Eukaryotic 32 18 25 5
ABCG2-2-E ATP-binding Cassette Sub-family G Member 2 (cluster #2 Of 2), Eukaryotic 51 12 10 4
Uniprot Swissprot Chembl Description Number Shared
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 9
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 7
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 5
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 5
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 5
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 5
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 5
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 5
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 4
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 4
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 4
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 4
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 4
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 4
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 3
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 3
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 3
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 3
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 3
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 3
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 3
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 3
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 3
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 3
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 3
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 3
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 3
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 2
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 2
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 2
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 2
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 2
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 2
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 2
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 2
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 2
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 2
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 2
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 2
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 2
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 2
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 2
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 2
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 2
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 2
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 2
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 2
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 2
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 2
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 2
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 2
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 2
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 2
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 2
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 2
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 2
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
A1Z199_HUMAN A1Z199 CHEMBL6105 BCR/ABL P210 Fusion Protein, Human 1
ABL1_MOUSE P00520 CHEMBL3099 Tyrosine-protein Kinase ABL, Mouse 1
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CD38_HUMAN P28907 CHEMBL4660 Lymphocyte Differentiation Antigen CD38, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 1
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 1
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 1
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 1
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 1
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 1
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 1
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 1
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 1
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 1
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 1
ERR1_HUMAN P11474 CHEMBL3429 Estrogen-related Receptor Alpha, Human 1
ERR2_HUMAN O95718 CHEMBL3751 Estrogen-related Receptor Beta, Human 1
FABI_ECOLI P0AEK4 CHEMBL1857 Enoyl-[acyl-carrier-protein] Reductase, Ecoli 1
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 1
IRAK3_HUMAN Q9Y616 CHEMBL5081 Interleukin-1 Receptor-associated Kinase 3, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
MELK_HUMAN Q14680 CHEMBL4578 Maternal Embryonic Leucine Zipper Kinase, Human 1
MGA_HUMAN O43451 CHEMBL2074 Maltase-glucoamylase, Human 1
MK04_HUMAN P31152 CHEMBL5759 Mitogen-activated Protein Kinase 4, Human 1
MK06_HUMAN Q16659 CHEMBL5121 Mitogen-activated Protein Kinase 6, Human 1
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 1
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 1
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 1
MRP2_HUMAN Q92887 CHEMBL5748 Canalicular Multispecific Organic Anion Transporter 1, Human 1
MRP3_HUMAN O15438 CHEMBL5918 Canalicular Multispecific Organic Anion Transporter 2, Human 1
MYLK2_HUMAN Q9H1R3 CHEMBL2777 Myosin Light Chain Kinase 2, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PHKG1_HUMAN Q16816 CHEMBL4004 Phosphorylase Kinase Gamma Subunit 1, Human 1
PHKG2_HUMAN P15735 CHEMBL2349 Phosphorylase Kinase Gamma Subunit 2, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 1
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
ST17B_HUMAN O94768 CHEMBL3980 Serine/threonine-protein Kinase 17B, Human 1
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 1
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 1
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 1
TOP1_RAT Q9WUL0 CHEMBL1075164 DNA Topoisomerase 1, Rat 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 1
ULK3_MOUSE Q3U3Q1 CHEMBL3832 ULK3 Kinase, Mouse 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1

Most Common Rings