UCSF

PI3-kinase P110-beta Subunit, Human (290 Compounds)

Swissprot:
PK3CB_HUMAN
Stitch:
PK3CB_HUMAN
UniProt:
P42338
ChEMBL:
CHEMBL3145
Reactome:
REACT_147727
REACT_147814
REACT_17025
REACT_12555
REACT_1695
REACT_23891
REACT_23837
REACT_23832
REACT_976
REACT_12464
REACT_75829
REACT_23787
REACT_163769
REACT_160158
REACT_121025
REACT_12621
REACT_228166
PDB:
PIK3CB

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 290 24 3 8
Binding ≤ 1μM 144 15 2 5

Reactome Network (17)

Reactome ID Description Species
REACT_147727 Constitutive PI3K/AKT Signaling in Cancer Homo sapiens
REACT_147814 DAP12 signaling Homo sapiens
REACT_17025 Downstream signal transduction Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_1695 GPVI-mediated activation cascade Homo sapiens
REACT_23891 Interleukin receptor SHC signaling Homo sapiens
REACT_23837 Interleukin-3, 5 and GM-CSF signaling Homo sapiens
REACT_23832 Nephrin interactions Homo sapiens
REACT_976 PI3K Cascade Homo sapiens
REACT_12464 PI3K/AKT activation Homo sapiens
REACT_75829 PIP3 activates AKT signaling Homo sapiens
REACT_23787 Regulation of signaling by CBL Homo sapiens
REACT_163769 Role of LAT2/NTAL/LAB on calcium mobilization Homo sapiens
REACT_160158 Role of phospholipids in phagocytosis Homo sapiens
REACT_121025 Synthesis of PIPs at the plasma membrane Homo sapiens
REACT_12621 Tie2 Signaling Homo sapiens
REACT_228166 VEGFA-VEGFR2 Pathway Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 7
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 93
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 162
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273

DAP12 signaling

Uniprot Swissprot Chembl Description Number Shared
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

Downstream signal transduction

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

Downstream TCR signaling

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

GPVI-mediated activation cascade

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 7
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 270

Interleukin receptor SHC signaling

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273

Interleukin-3, 5 and GM-CSF signaling

Uniprot Swissprot Chembl Description Number Shared
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273

Nephrin interactions

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

PI3K Cascade

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3C3_HUMAN Q8NEB9 CHEMBL1075165 Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

PI3K/AKT activation

Uniprot Swissprot Chembl Description Number Shared
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

PIP3 activates AKT signaling

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 7
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 93
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 162
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273

Regulation of signaling by CBL

Uniprot Swissprot Chembl Description Number Shared
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 128
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273

Role of LAT2/NTAL/LAB on calcium mobilization

Uniprot Swissprot Chembl Description Number Shared
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

Role of phospholipids in phagocytosis

Uniprot Swissprot Chembl Description Number Shared
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

Synthesis of PIPs at the plasma membrane

Uniprot Swissprot Chembl Description Number Shared
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 7
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 270

Tie2 Signaling

Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273

VEGFA-VEGFR2 Pathway

Uniprot Swissprot Chembl Description Number Shared
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 102

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PK3CB-1-E PI3-kinase P110-beta Subunit (cluster #1 Of 2), Eukaryotic 21 6 2 3
PK3CB-2-E PI3-kinase P110-beta Subunit (cluster #2 Of 2), Eukaryotic 274 19 1 5
Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 273
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 273
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 270
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 162
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 140
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 128
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 124
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 122
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 102
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 100
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 93
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 61
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 14
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 7
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 7
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 5
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 5
Q9BJF5_TOXGO Q9BJF5 CHEMBL1781862 Calmodulin-domain Protein Kinase 1, Toxgo 4
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 3
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 2
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 2
PK3CA_MOUSE P42337 CHEMBL2499 PI3-kinase P110-alpha Subunit, Mouse 2
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 2
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 2
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DAPK1_HUMAN P53355 CHEMBL2558 Death-associated Protein Kinase 1, Human 1
DAPK2_HUMAN Q9UIK4 CHEMBL3123 Death-associated Protein Kinase 2, Human 1
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
KCC2A_MOUSE P11798 CHEMBL3347 CaM Kinase II Alpha, Mouse 1
KCC2B_MOUSE P28652 CHEMBL4735 CaM Kinase II Beta, Mouse 1
KCC2G_MOUSE Q923T9 CHEMBL4456 CaM Kinase II Gamma, Mouse 1
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
M3K9_HUMAN P80192 CHEMBL2872 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
MTOR_RAT P42346 CHEMBL1075134 Serine/threonine-protein Kinase MTOR, Rat 1
MYLK_CHICK P11799 CHEMBL3062 Myosin Light Chain Kinase, Smooth Muscle, Chick 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3C3_HUMAN Q8NEB9 CHEMBL1075165 Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1

Most Common Rings