UCSF

Serine/threonine-protein Kinase B-raf, Human (423 Compounds)

Swissprot:
BRAF_HUMAN
Stitch:
BRAF_HUMAN
UniProt:
P15056
ChEMBL:
CHEMBL5145
Reactome:
REACT_12002
REACT_20568
REACT_12076
REACT_12077
REACT_111080
PDB:
1UWH (DOCK)
1UWJ (DOCK)
2FB8 (DOCK)
2L05 (DOCK)
3C4C (DOCK)
3C4D (DOCK)
3D4Q (DOCK)
3IDP (DOCK)
3II5 (DOCK)
3NY5 (DOCK)
3OG7 (DOCK)
3PPJ (DOCK)
3PPK (DOCK)
3PRF (DOCK)
3PRI (DOCK)
3PSB (DOCK)
3PSD (DOCK)
3Q4C (DOCK)
3Q96 (DOCK)
3SKC (DOCK)
3TV4 (DOCK)
3TV6 (DOCK)
BRAF

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 423 22 6 8
Binding ≤ 1μM 371 16 5 7
Functional ≤ 10μM 28 1 1 1

Reactome Network (5)

Reactome ID Description Species
REACT_12002 ARMS-mediated activation Homo sapiens
REACT_20568 CREB phosphorylation through the activation of Ras Homo sapiens
REACT_12076 Frs2-mediated activation Homo sapiens
REACT_12077 Signalling to p38 via RIT and RIN Homo sapiens
REACT_111080 Spry regulation of FGF signaling Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 7

CREB phosphorylation through the activation of Ras

Uniprot Swissprot Chembl Description Number Shared
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 4
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 5
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 5
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 43

Frs2-mediated activation

Uniprot Swissprot Chembl Description Number Shared
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 7

Signalling to p38 via RIT and RIN

Uniprot Swissprot Chembl Description Number Shared
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 7

Spry regulation of FGF signaling

Uniprot Swissprot Chembl Description Number Shared
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 55
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 43
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 36
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 26
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 20
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 19
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 18
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 14
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 14
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 14
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 13
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 13
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 12
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 12
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 11
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 11
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 11
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 10
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 10
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 10
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 10
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 10
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 9
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 9
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 9
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 9
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 8
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 8
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 8
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 8
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 8
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 8
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 8
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 8
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 8
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 8
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 7
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 7
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 7
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 7
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 7
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 7
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 7
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 7
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 7
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 7
ABL1_MOUSE P00520 CHEMBL3099 Tyrosine-protein Kinase ABL, Mouse 6
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 6
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 6
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 6
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 6
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 6
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 6
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 5
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 5
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 5
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 5
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 5
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 5
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 5
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 5
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 5
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 5
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 5
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 5
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 5
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 5
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 5
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 5
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 4
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 4
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 4
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 4
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 4
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 4
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 4
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 4
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 4
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 4
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 4
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 4
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 4
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 4
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 4
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 4
PIM2_HUMAN Q9P1W9 CHEMBL4523 Serine/threonine-protein Kinase PIM2, Human 4
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 4
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 4
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 4
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 4
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 3
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 3
AVR2B_HUMAN Q13705 CHEMBL5466 Activin Receptor Type-2B, Human 3
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 3
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 3
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 3
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 3
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 3
E2AK2_HUMAN P19525 CHEMBL5785 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 3
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 3
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 3
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 3
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 3
KC1AL_HUMAN Q8N752 CHEMBL5520 Casein Kinase I Isoform Alpha-like, Human 3
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 3
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 3
M3K11_HUMAN Q16584 CHEMBL2708 Mitogen-activated Protein Kinase Kinase Kinase 11, Human 3
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 3
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 3
MK14_MOUSE P47811 CHEMBL2336 MAP Kinase P38 Alpha, Mouse 3
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 3
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 3
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 3
MYLK2_HUMAN Q9H1R3 CHEMBL2777 Myosin Light Chain Kinase 2, Human 3
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 3
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 Growth Factor Receptor, Human 3
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 3
SIK1_HUMAN P57059 CHEMBL6082 Serine/threonine-protein Kinase SIK1, Human 3
ST32B_HUMAN Q9NY57 CHEMBL5912 Serine/threonine-protein Kinase 32B, Human 3
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 3
TNK1_HUMAN Q13470 CHEMBL5334 Non-receptor Tyrosine-protein Kinase TNK1, Human 3
AAPK1_HUMAN Q13131 CHEMBL4045 AMP-activated Protein Kinase, Alpha-1 Subunit, Human 2
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 2
ANKK1_HUMAN Q8NFD2 CHEMBL5547 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 2
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 2
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 2
BTK_HUMAN Q06187 CHEMBL5251 Tyrosine-protein Kinase BTK, Human 2
CD11A_HUMAN Q9UQ88 CHEMBL5416 PITSLRE Serine/threonine-protein Kinase CDC2L2, Human 2
CD11B_HUMAN P21127 CHEMBL5808 PITSLRE Serine/threonine-protein Kinase CDC2L1, Human 2
CDK14_HUMAN O94921 CHEMBL6162 Serine/threonine-protein Kinase PFTAIRE-1, Human 2
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 2
CDK17_HUMAN Q00537 CHEMBL5790 Serine/threonine-protein Kinase PCTAIRE-2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 2
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 2
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 2
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 2
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 2
FAK2_HUMAN Q14289 CHEMBL5469 Protein Tyrosine Kinase 2 Beta, Human 2
FER_HUMAN P16591 CHEMBL3982 Tyrosine-protein Kinase FER, Human 2
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 2
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 2
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 2
KCC1A_HUMAN Q14012 CHEMBL2493 CaM Kinase I Alpha, Human 2
LATS2_HUMAN Q9NRM7 CHEMBL5907 Serine/threonine-protein Kinase LATS2, Human 2
LCK_MOUSE P06240 CHEMBL2480 Tyrosine-protein Kinase LCK, Mouse 2
LTK_HUMAN P29376 CHEMBL5627 Leukocyte Tyrosine Kinase Receptor, Human 2
M3K8_HUMAN P41279 CHEMBL4899 Mitogen-activated Protein Kinase Kinase Kinase 8, Human 2
MELK_HUMAN Q14680 CHEMBL4578 Maternal Embryonic Leucine Zipper Kinase, Human 2
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 2
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 2
NEK5_HUMAN Q6P3R8 CHEMBL5044 Serine/threonine-protein Kinase Nek5, Human 2
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 2
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 2
Q5SC61_TOXGO Q5SC61 CHEMBL6051 Mitogen-activated Protein Kinase 1, Toxgo 2
RIPK1_HUMAN Q13546 CHEMBL5464 Receptor-interacting Serine/threonine-protein Kinase 1, Human 2
ROS1_HUMAN P08922 CHEMBL5568 Proto-oncogene Tyrosine-protein Kinase ROS, Human 2
SGK1_HUMAN O00141 CHEMBL2343 Serine/threonine-protein Kinase Sgk1, Human 2
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 2
STK33_HUMAN Q9BYT3 CHEMBL6005 Serine/threonine-protein Kinase 33, Human 2
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 2
TESK1_HUMAN Q15569 CHEMBL5604 Dual Specificity Testis-specific Protein Kinase 1, Human 2
TYK2_HUMAN P29597 CHEMBL3553 Tyrosine-protein Kinase TYK2, Human 2
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 2
A1Z199_HUMAN A1Z199 CHEMBL6105 BCR/ABL P210 Fusion Protein, Human 1
AAK1_HUMAN Q2M2I8 CHEMBL3830 Adaptor-associated Kinase, Human 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
ACK1_HUMAN Q07912 CHEMBL4599 Tyrosine Kinase Non-receptor Protein 2, Human 1
ACVL1_HUMAN P37023 CHEMBL5311 Serine/threonine-protein Kinase Receptor R3, Human 1
ACVR1_HUMAN Q04771 CHEMBL5903 Activin Receptor Type-1, Human 1
ADCK3_HUMAN Q8NI60 CHEMBL5550 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 1
AVR2A_HUMAN P27037 CHEMBL5616 Activin Receptor Type-2A, Human 1
BLK_MOUSE P16277 CHEMBL3343 Tyrosine-protein Kinase BLK, Mouse 1
BMP2K_HUMAN Q9NSY1 CHEMBL4522 BMP-2-inducible Protein Kinase, Human 1
BMX_HUMAN P51813 CHEMBL3834 Tyrosine-protein Kinase BMX, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK15_HUMAN Q96Q40 CHEMBL5856 Serine/threonine-protein Kinase PFTAIRE-2, Human 1
CDK18_HUMAN Q07002 CHEMBL5316 Serine/threonine-protein Kinase PCTAIRE-3, Human 1
CDK3_HUMAN Q00526 CHEMBL4442 Cyclin-dependent Kinase 3, Human 1
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 1
CDKL2_HUMAN Q92772 CHEMBL5728 Cyclin-dependent Kinase-like 2, Human 1
CDKL3_HUMAN Q8IVW4 CHEMBL1163117 Cyclin-dependent Kinase-like 3, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
DAPK1_HUMAN P53355 CHEMBL2558 Death-associated Protein Kinase 1, Human 1
DAPK2_HUMAN Q9UIK4 CHEMBL3123 Death-associated Protein Kinase 2, Human 1
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 1
EPHB3_HUMAN P54753 CHEMBL4901 Ephrin Type-B Receptor 3, Human 1
EPHB6_HUMAN O15197 CHEMBL5836 Ephrin Type-B Receptor 6, Human 1
FES_HUMAN P07332 CHEMBL5455 Tyrosine-protein Kinase FES, Human 1
HIPK1_HUMAN Q86Z02 CHEMBL5427 Homeodomain-interacting Protein Kinase 1, Human 1
HIPK2_HUMAN Q9H2X6 CHEMBL4576 Homeodomain-interacting Protein Kinase 2, Human 1
HIPK3_HUMAN Q9H422 CHEMBL4577 Homeodomain-interacting Protein Kinase 3, Human 1
HIPK4_HUMAN Q8NE63 CHEMBL1075167 Homeodomain-interacting Protein Kinase 4, Human 1
HSPB1_HUMAN P04792 CHEMBL5976 Heat Shock Protein Beta-1, Human 1
HXK4_HUMAN P35557 CHEMBL3820 Hexokinase Type IV, Human 1
INSRR_HUMAN P14616 CHEMBL5483 Insulin Receptor-related Protein, Human 1
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 1
IRAK3_HUMAN Q9Y616 CHEMBL5081 Interleukin-1 Receptor-associated Kinase 3, Human 1
ITK_HUMAN Q08881 CHEMBL2959 Tyrosine-protein Kinase ITK/TSK, Human 1
JAK1_HUMAN P23458 CHEMBL2835 Tyrosine-protein Kinase JAK1, Human 1
KC1G2_HUMAN P78368 CHEMBL2543 Casein Kinase I Gamma 2, Human 1
KC1G3_HUMAN Q9Y6M4 CHEMBL5084 Casein Kinase I Isoform Gamma-3, Human 1
KCC1G_HUMAN Q96NX5 CHEMBL5258 CaM Kinase I Gamma, Human 1
KCC4_HUMAN Q16566 CHEMBL2494 CaM Kinase IV, Human 1
KKCC1_HUMAN Q8N5S9 CHEMBL5256 CaM-kinase Kinase Alpha, Human 1
KKCC2_HUMAN Q96RR4 CHEMBL5284 CaM-kinase Kinase Beta, Human 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 1
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 1
KPCD2_HUMAN Q9BZL6 CHEMBL4900 Serine/threonine-protein Kinase D2, Human 1
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 1
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 1
KS6A5_HUMAN O75582 CHEMBL4237 Ribosomal Protein S6 Kinase Alpha 5, Human 1
LATS1_HUMAN O95835 CHEMBL6167 Serine/threonine-protein Kinase LATS1, Human 1
M3K10_HUMAN Q02779 CHEMBL2873 Mitogen-activated Protein Kinase Kinase Kinase 10, Human 1
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
M3K9_HUMAN P80192 CHEMBL2872 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 1
MARK3_HUMAN P27448 CHEMBL5600 Serine/threonine-protein Kinase C-TAK1, Human 1
MP2K4_HUMAN P45985 CHEMBL2897 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 1
MP2K6_HUMAN P52564 CHEMBL2171 Dual Specificity Mitogen-activated Protein Kinase Kinase 6, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
MYO3A_HUMAN Q8NEV4 CHEMBL5546 Myosin IIIA, Human 1
MYO3B_HUMAN Q8WXR4 CHEMBL5654 Myosin-IIIB, Human 1
NEK2_HUMAN P51955 CHEMBL3835 Serine/threonine-protein Kinase NEK2, Human 1
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 1
PAK3_HUMAN O75914 CHEMBL2999 Serine/threonine-protein Kinase PAK 3, Human 1
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 1
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PMYT1_HUMAN Q99640 CHEMBL3984 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 1
Q8IXA3_HUMAN Q8IXA3 CHEMBL5434 Casein Kinase I Gamma 1 Isoform, Human 1
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
STK16_HUMAN O75716 CHEMBL3938 Serine/threonine-protein Kinase 16, Human 1
STK25_HUMAN O00506 CHEMBL5552 Serine/threonine-protein Kinase 25, Human 1
STK3_HUMAN Q13188 CHEMBL4708 Serine/threonine-protein Kinase MST2, Human 1
TAOK1_HUMAN Q7L7X3 CHEMBL5261 Serine/threonine-protein Kinase TAO1, Human 1
TAOK3_HUMAN Q9H2K8 CHEMBL5701 Serine/threonine-protein Kinase TAO3, Human 1
TEC_HUMAN P42680 CHEMBL4246 Tyrosine-protein Kinase TEC, Human 1
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1
YSK4_HUMAN Q56UN5 CHEMBL6191 SPS1/STE20-related Protein Kinase YSK4, Human 1
Z100405 Z100405 CHEMBL613835 MV4-11 (Myeloid Leukemia Cells) 1
Z103203 Z103203 CHEMBL1075388 A375 1
Z104299 Z104299 CHEMBL1907605 Cyclin-dependent Kinase 2/cyclin E1 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 1
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 1
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81338 Z81338 CHEMBL614309 T-cells 1
ZAP70_HUMAN P43403 CHEMBL2803 Tyrosine-protein Kinase ZAP-70, Human 1

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