UCSF

Mitogen-activated Protein Kinase Kinase Kinase 8, Human (172 Compounds)

Swissprot:
M3K8_HUMAN
Stitch:
M3K8_HUMAN
UniProt:
P41279
ChEMBL:
CHEMBL4899
Reactome:
REACT_19358
REACT_22442
PDB:
MAP3K8

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 172 3 0 0
Binding ≤ 1μM 136 2 0 0
Functional ≤ 10μM 16 1 0 0

Reactome Network (2)

Uniprot Swissprot Chembl Description Number Shared
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1

Interleukin-1 signaling

Uniprot Swissprot Chembl Description Number Shared
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 14
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
M3K10_HUMAN Q02779 CHEMBL2873 Mitogen-activated Protein Kinase Kinase Kinase 10, Human 19 5 4 4
M3K11_HUMAN Q16584 CHEMBL2708 Mitogen-activated Protein Kinase Kinase Kinase 11, Human 43 9 5 6
M3K13_HUMAN O43283 CHEMBL1163124 Mitogen-activated Protein Kinase Kinase Kinase 13, Human 1 1 1 1
M3K14_HUMAN Q99558 CHEMBL5888 Mitogen-activated Protein Kinase Kinase Kinase 14, Human 2 1 1 1
M3K15_HUMAN Q6ZN16 CHEMBL1163127 Mitogen-activated Protein Kinase Kinase Kinase 15, Human 1 1 1 1
M3K1_HUMAN Q13233 CHEMBL3956 Mitogen-activated Protein Kinase Kinase Kinase 1, Human 1 0 0 0
M3K2_HUMAN Q9Y2U5 CHEMBL5914 Mitogen-activated Protein Kinase Kinase Kinase 2, Human 1 1 1 1
M3K3_HUMAN Q99759 CHEMBL5970 Mitogen-activated Protein Kinase Kinase Kinase 3, Human 1 1 1 1
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 8 8 6 7
M3K5_HUMAN Q99683 CHEMBL5285 Mitogen-activated Protein Kinase Kinase Kinase 5, Human 9 5 4 1
M3K6_HUMAN O95382 CHEMBL1163123 Mitogen-activated Protein Kinase Kinase Kinase 6, Human 0 0 0 0
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 20 5 4 4
M3K9_HUMAN P80192 CHEMBL2872 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 47 12 6 8

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 11
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 6
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 5
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 5
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 5
Z100744 Z100744 CHEMBL613301 Monocytes 5
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 4
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 2
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 1
KCC2A_HUMAN Q9UQM7 CHEMBL4147 CaM Kinase II Alpha, Human 1
KCC2B_HUMAN Q13554 CHEMBL4121 CaM Kinase II Beta, Human 1
KCC2D_HUMAN Q13557 CHEMBL2801 CaM Kinase II Delta, Human 1
KCC2G_HUMAN Q13555 CHEMBL3829 CaM Kinase II Gamma, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1