ZINC 12

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Names
Compounds (2,212)
Reactome (5)
Related By:
Pathway (30)
Organism (0)
Gene (15)
Org. Clust. (2)
ChEMBL (58)
Rings (50)

Matrix Metalloproteinase 3, Human (2,212 Compounds)

Swissprot:: MMP3_HUMAN
Stitch:: MMP3_HUMAN
UniProt:: P08254
ChEMBL:: CHEMBL283
Reactome:: REACT_118682; REACT_150180; REACT_150401; REACT_118572; REACT_121096
PDB:: 1B3D (DOCK); 1B8Y (DOCK); 1BIW (DOCK); 1BM6 (DOCK); 1BQO (DOCK); 1C3I (DOCK); 1C8T (DOCK); 1CAQ (DOCK); 1CIZ (DOCK); 1CQR (DOCK); 1D5J (DOCK); 1D7X (DOCK); 1D8F (DOCK); 1D8M (DOCK); 1G05 (DOCK); 1G49 (DOCK); 1G4K (DOCK); 1HFS (DOCK); 1HY7 (DOCK); 1M1W (DOCK); 1OO9 (DOCK); 1QIA (DOCK); 1QIC (DOCK); 1SLM (DOCK); 1SLN (DOCK); 1UEA (DOCK); 1UMS (DOCK); 1UMT (DOCK); 1USN (DOCK); 2D1O (DOCK); 2JNP (DOCK); 2JT5 (DOCK); 2JT6 (DOCK); 2SRT (DOCK); 2USN (DOCK); 3OHL (DOCK); 3OHO (DOCK); 3USN (DOCK); MMP3

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2,212	22	9	40
Binding ≤ 1μM	1,731	16	6	33

Reactome ID	Description	Species
REACT_118682	Activation of Matrix Metalloproteinases	Homo sapiens
REACT_150180	Assembly of collagen fibrils and other multimeric structures	Homo sapiens
REACT_150401	Collagen degradation	Homo sapiens
REACT_118572	Degradation of the extracellular matrix	Homo sapiens
REACT_121096	EGFR Transactivation by Gastrin	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	73
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	66
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	702
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	121
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	20
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	29
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1103
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1109
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	386
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	534
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	834

Assembly of collagen fibrils and other multimeric structures

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	702
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	386
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	834

Collagen degradation

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	34
ADA17_HUMAN	P78536	CHEMBL3706	ADAM17, Human	245
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	65
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	73
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	66
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	60
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	702
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	121
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1103
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1109
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	386
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	534
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	834

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	34
ADAM8_HUMAN	P78325	CHEMBL5665	Disintegrin And Metalloproteinase Domain-containing Protein 8, Human	1
ATS1_HUMAN	Q9UHI8	CHEMBL5133	ADAMTS1, Human	3
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	11
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	6
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	3
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	73
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	66
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	60
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	702
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	121
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1103
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1109
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	386
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	534
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	834

EGFR Transactivation by Gastrin

Uniprot	Swissprot	Chembl	Description	Number Shared
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	82	1	1	1
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	71	1	1	1
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	289	8	4	5
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	2,513	43	6	37
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	507	9	8	14
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	30	1	1	3
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	61	3	1	4
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	29	1	1	1
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	2,665	22	9	44
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8	0	0	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	23	1	1	2
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	2,765	37	17	44
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	467	10	4	22
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	980	16	6	25
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	2,243	31	11	34

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
MMP3-1-E	Matrix Metalloproteinase 3 (cluster #1 Of 3), Eukaryotic	2,093	21	10	37
MMP3-2-E	Matrix Metalloproteinase 3 (cluster #2 Of 3), Eukaryotic	146	4	2	7
MMP3-3-E	Matrix Metalloproteinase 3 (cluster #3 Of 3), Eukaryotic	3	0	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	1109
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	1103
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	834
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	702
MMP8_HUMAN	P22894	CHEMBL4588	Matrix Metalloproteinase 8, Human	534
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	386
ADA17_HUMAN	P78536	CHEMBL3706	ADAM17, Human	227
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	121
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	73
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	66
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	65
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	60
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	34
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	29
ADA17_PIG	O77636	CHEMBL3332	ADAM17, Pig	25
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	20
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	16
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	16
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	16
PDE4D_HUMAN	Q08499	CHEMBL288	Phosphodiesterase 4D, Human	16
MMP13_RAT	P23097	CHEMBL4944	Matrix Metalloproteinase 13, Rat	12
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	11
ERBB2_HUMAN	P04626	CHEMBL1824	Receptor Protein-tyrosine Kinase ErbB-2, Human	11
MMP12_MOUSE	P34960	CHEMBL2594	Matrix Metalloproteinase 12, Mouse	9
CAH4_BOVIN	Q95323	CHEMBL281	Carbonic Anhydrase IV, Bovin	8
FCER2_HUMAN	P06734	CHEMBL2940	Immunoglobulin Epsilon Fc Receptor, Human	8
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	6
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	6
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
CASP1_HUMAN	P29466	CHEMBL4801	Caspase-1, Human	5
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	4
MMP13_BOVIN	O77656	CHEMBL5327	Matrix Metalloproteinase 13, Bovin	4
TNFA_HUMAN	P01375	CHEMBL1825	TNF-alpha, Human	4
ATS1_HUMAN	Q9UHI8	CHEMBL5133	ADAMTS1, Human	3
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	3
DEF_ECOLI	P0A6K3	CHEMBL4976	Peptide Deformylase, Ecoli	3
LEF_BACAN	P15917	CHEMBL4372	Anthrax Lethal Factor, Bacan	3
MMP2_MOUSE	P33434	CHEMBL3095	Matrix Metalloproteinase-2, Mouse	3
MMP9_MOUSE	P41245	CHEMBL2214	Matrix Metalloproteinase 9, Mouse	3
ADA33_HUMAN	Q9BZ11	CHEMBL6121	Disintegrin And Metalloproteinase Domain-containing Protein 33, Human	2
MMP12_RAT	Q63341	CHEMBL5506	Macrophage Metalloelastase, Rat	2
NEP_HUMAN	P08473	CHEMBL1944	Neprilysin, Human	2
ADA12_HUMAN	O43184	CHEMBL5030	ADAM12, Human	1
ADAM8_HUMAN	P78325	CHEMBL5665	Disintegrin And Metalloproteinase Domain-containing Protein 8, Human	1
ATS5_BOVIN	Q9TT92	CHEMBL2673	ADAMTS5, Bovin	1
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	1
DEF1A_ARATH	Q9FV53	CHEMBL1075041	Peptide Deformylase 1A, Chloroplastic, Arath	1
DEFM_HUMAN	Q9HBH1	CHEMBL4647	Peptide Deformylase Mitochondrial, Human	1
DEF_STAAM	P68825	CHEMBL2367	Peptide Deformylase, Staam	1
ECE1_HUMAN	P42892	CHEMBL4791	Endothelin-converting Enzyme 1, Human	1
M3K8_HUMAN	P41279	CHEMBL4899	Mitogen-activated Protein Kinase Kinase Kinase 8, Human	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	1
MMP8_RAT	O88766	CHEMBL2312	Matrix Metalloproteinase 8, Rat	1
MMP9_RAT	P50282	CHEMBL3870	Matrix Metalloproteinase 9, Rat	1
Q72874_9HIV1	Q72874	CHEMBL243	Human Immunodeficiency Virus Type 1 Protease, 9hiv1	1
Q9JN24_ECOLX	Q9JN24	CHEMBL1795101	Peptide Deformylase, Ecolx	1
TIMP3_RAT	P48032	CHEMBL3881	Tissue Inhibitor Of Metalloproteinases-3, Rat	1