UCSF

Matrix Metalloproteinase 3, Human (2,212 Compounds)

Swissprot:
MMP3_HUMAN
Stitch:
MMP3_HUMAN
UniProt:
P08254
ChEMBL:
CHEMBL283
Reactome:
REACT_118682
REACT_150180
REACT_150401
REACT_118572
REACT_121096
PDB:
1B3D (DOCK)
1B8Y (DOCK)
1BIW (DOCK)
1BM6 (DOCK)
1BQO (DOCK)
1C3I (DOCK)
1C8T (DOCK)
1CAQ (DOCK)
1CIZ (DOCK)
1CQR (DOCK)
1D5J (DOCK)
1D7X (DOCK)
1D8F (DOCK)
1D8M (DOCK)
1G05 (DOCK)
1G49 (DOCK)
1G4K (DOCK)
1HFS (DOCK)
1HY7 (DOCK)
1M1W (DOCK)
1OO9 (DOCK)
1QIA (DOCK)
1QIC (DOCK)
1SLM (DOCK)
1SLN (DOCK)
1UEA (DOCK)
1UMS (DOCK)
1UMT (DOCK)
1USN (DOCK)
2D1O (DOCK)
2JNP (DOCK)
2JT5 (DOCK)
2JT6 (DOCK)
2SRT (DOCK)
2USN (DOCK)
3OHL (DOCK)
3OHO (DOCK)
3USN (DOCK)
MMP3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,212 22 9 40
Binding ≤ 1μM 1,731 16 6 33
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 73
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 66
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 702
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 121
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 20
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1103
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1109
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 386
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 534
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 834

Assembly of collagen fibrils and other multimeric structures

Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 702
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 386
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 834

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 34
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 245
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 65
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 73
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 66
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 60
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 702
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 121
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1103
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1109
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 386
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 534
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 834

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 34
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 3
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 11
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 6
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 3
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 73
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 66
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 60
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 702
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 121
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1103
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1109
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 386
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 534
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 834

EGFR Transactivation by Gastrin

Uniprot Swissprot Chembl Description Number Shared
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MMP3-1-E Matrix Metalloproteinase 3 (cluster #1 Of 3), Eukaryotic 2,093 21 10 37
MMP3-2-E Matrix Metalloproteinase 3 (cluster #2 Of 3), Eukaryotic 146 4 2 7
MMP3-3-E Matrix Metalloproteinase 3 (cluster #3 Of 3), Eukaryotic 3 0 0 0
Uniprot Swissprot Chembl Description Number Shared
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1109
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 1103
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 834
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 702
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 534
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 386
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 227
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 121
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 73
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 66
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 65
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 60
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 34
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 25
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 20
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 16
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 16
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 16
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 16
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 12
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 11
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 11
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 9
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 8
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 8
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 6
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 6
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 6
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 5
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 4
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 4
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 4
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 3
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 3
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 3
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 3
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 3
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 3
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 2
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 2
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 2
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
DEF1A_ARATH Q9FV53 CHEMBL1075041 Peptide Deformylase 1A, Chloroplastic, Arath 1
DEFM_HUMAN Q9HBH1 CHEMBL4647 Peptide Deformylase Mitochondrial, Human 1
DEF_STAAM P68825 CHEMBL2367 Peptide Deformylase, Staam 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
M3K8_HUMAN P41279 CHEMBL4899 Mitogen-activated Protein Kinase Kinase Kinase 8, Human 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 1
MMP8_RAT O88766 CHEMBL2312 Matrix Metalloproteinase 8, Rat 1
MMP9_RAT P50282 CHEMBL3870 Matrix Metalloproteinase 9, Rat 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q9JN24_ECOLX Q9JN24 CHEMBL1795101 Peptide Deformylase, Ecolx 1
TIMP3_RAT P48032 CHEMBL3881 Tissue Inhibitor Of Metalloproteinases-3, Rat 1