UCSF

ADAMTS4, Human (190 Compounds)

Swissprot:
ATS4_HUMAN
Stitch:
ATS4_HUMAN
UniProt:
O75173
ChEMBL:
CHEMBL2318
Reactome:
REACT_118572
REACT_200626
PDB:
2RJP (DOCK)
3B2Z (DOCK)
ADAMTS4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 190 3 0 2
Binding ≤ 1μM 146 0 0 2

Reactome Network (2)

Reactome ID Description Species
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_200626 O-glycosylation of TSR domain-containing proteins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 3
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 76
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 2
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 77
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 28
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 45
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 58
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 11
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 6
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 15
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 29

O-glycosylation of TSR domain-containing proteins

Uniprot Swissprot Chembl Description Number Shared
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 3
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 76
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ATS4_BOVIN Q9TT93 CHEMBL3874 ADAMTS4, Bovin 12 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 3 0 0 0
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 352 25 0 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 77
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 76
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 58
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 45
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 31
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 29
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 28
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 23
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 18
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 15
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 14
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 11
ADA17_RAT Q9Z1K9 CHEMBL2523 ADAM17, Rat 6
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 6
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 4
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 3
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 2
ATS4_BOVIN Q9TT93 CHEMBL3874 ADAMTS4, Bovin 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 1
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 1

Most Common Rings