ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (980)
Reactome (3)
Related By:
Pathway (32)
Organism (1)
Gene (15)
Org. Clust. (3)
ChEMBL (55)
Rings (50)

Matrix Metalloproteinase 8, Human (980 Compounds)

Swissprot:: MMP8_HUMAN
Stitch:: MMP8_HUMAN
UniProt:: P22894
ChEMBL:: CHEMBL4588
Reactome:: REACT_118682; REACT_150401; REACT_118572
PDB:: 1A85 (DOCK); 1A86 (DOCK); 1BZS (DOCK); 1I73 (DOCK); 1I76 (DOCK); 1JAN (DOCK); 1JAO (DOCK); 1JAP (DOCK); 1JAQ (DOCK); 1JH1 (DOCK); 1JJ9 (DOCK); 1KBC (DOCK); 1MMB (DOCK); 1MNC (DOCK); 1ZP5 (DOCK); 1ZS0 (DOCK); 1ZVX (DOCK); 2OY2 (DOCK); 2OY4 (DOCK); 3DNG (DOCK); 3DPE (DOCK); 3DPF (DOCK); MMP8

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	980	16	6	25
Binding ≤ 1μM	855	12	6	22

Reactome ID	Description	Species
REACT_118682	Activation of Matrix Metalloproteinases	Homo sapiens
REACT_150401	Collagen degradation	Homo sapiens
REACT_118572	Degradation of the extracellular matrix	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	67
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	68
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	434
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	198
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	35
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	1
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	402
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	641
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	534
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	119
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	610

Collagen degradation

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	3
ADA17_HUMAN	P78536	CHEMBL3706	ADAM17, Human	32
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	1
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	67
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	68
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	83
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	434
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	198
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	402
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	641
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	534
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	119
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	610

Degradation of the extracellular matrix

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	3
ATS1_HUMAN	Q9UHI8	CHEMBL5133	ADAMTS1, Human	2
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	15
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	10
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	4
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	67
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	68
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	83
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	434
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	198
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	402
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	641
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	534
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	119
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	610

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MMP8_RAT	O88766	CHEMBL2312	Matrix Metalloproteinase 8, Rat	11	0	0	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	82	1	1	1
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	71	1	1	1
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	289	8	4	5
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	2,513	43	6	37
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	507	9	8	14
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	30	1	1	3
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	61	3	1	4
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	29	1	1	1
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	2,665	22	9	44
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8	0	0	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	23	1	1	2
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	2,765	37	17	44
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	2,212	22	9	40
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	467	10	4	22
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	2,243	31	11	34

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
MMP8-1-E	Matrix Metalloproteinase 8 (cluster #1 Of 4), Eukaryotic	615	7	6	16
MMP8-2-E	Matrix Metalloproteinase 8 (cluster #2 Of 4), Eukaryotic	5	0	0	0
MMP8-3-E	Matrix Metalloproteinase 8 (cluster #3 Of 4), Eukaryotic	111	4	0	3
MMP8-4-E	Matrix Metalloproteinase 8 (cluster #4 Of 4), Eukaryotic	345	6	1	7

Uniprot	Swissprot	Chembl	Description	Number Shared
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	641
MMP9_HUMAN	P14780	CHEMBL321	Matrix Metalloproteinase 9, Human	610
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	534
MMP13_HUMAN	P45452	CHEMBL280	Matrix Metalloproteinase 13, Human	434
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	402
MMP14_HUMAN	P50281	CHEMBL3869	Matrix Metalloproteinase 14, Human	198
MMP7_HUMAN	P09237	CHEMBL4073	Matrix Metalloproteinase 7, Human	119
MMP12_HUMAN	P39900	CHEMBL4393	Matrix Metalloproteinase 12, Human	83
MMP11_HUMAN	P24347	CHEMBL2867	Matrix Metalloproteinase 11, Human	68
MMP10_HUMAN	P09238	CHEMBL4270	Matrix Metalloproteinase 10, Human	67
MMP11_MOUSE	Q02853	CHEMBL3412	Matrix Metalloproteinase 11, Mouse	65
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	56
CAH4_BOVIN	Q95323	CHEMBL281	Carbonic Anhydrase IV, Bovin	51
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	45
COLA_CLOPE	P43153	CHEMBL2802	Microbial Collagenase, Clope	36
MMP16_HUMAN	P51512	CHEMBL2200	Matrix Metalloproteinase 16, Human	35
ADA17_HUMAN	P78536	CHEMBL3706	ADAM17, Human	29
ATS4_HUMAN	O75173	CHEMBL2318	ADAMTS4, Human	15
ADA17_PIG	O77636	CHEMBL3332	ADAM17, Pig	11
MMP13_RAT	P23097	CHEMBL4944	Matrix Metalloproteinase 13, Rat	11
ATS5_HUMAN	Q9UNA0	CHEMBL2285	ADAMTS5, Human	10
MMP25_HUMAN	Q9NPA2	CHEMBL1795103	Matrix Metalloproteinase-25, Human	8
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	7
MMP12_MOUSE	P34960	CHEMBL2594	Matrix Metalloproteinase 12, Mouse	7
AMP1_PLAFQ	O96935	CHEMBL4117	Zinc Aminopeptidase, Plafq	6
MMP15_HUMAN	P51511	CHEMBL2963	Matrix Metalloproteinase 15, Human	6
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	4
ADA10_HUMAN	O14672	CHEMBL5028	ADAM10, Human	3
AMPN_PIG	P15145	CHEMBL2590	Aminopeptidase N, Pig	2
ATS1_HUMAN	Q9UHI8	CHEMBL5133	ADAMTS1, Human	2
ATS5_BOVIN	Q9TT92	CHEMBL2673	ADAMTS5, Bovin	2
LEF_BACAN	P15917	CHEMBL4372	Anthrax Lethal Factor, Bacan	2
ADA12_HUMAN	O43184	CHEMBL5030	ADAM12, Human	1
ADA33_HUMAN	Q9BZ11	CHEMBL6121	Disintegrin And Metalloproteinase Domain-containing Protein 33, Human	1
ADAM9_HUMAN	Q13443	CHEMBL5982	ADAM9, Human	1
ATS4_BOVIN	Q9TT93	CHEMBL3874	ADAMTS4, Bovin	1
DEF1A_ARATH	Q9FV53	CHEMBL1075041	Peptide Deformylase 1A, Chloroplastic, Arath	1
DEFM_HUMAN	Q9HBH1	CHEMBL4647	Peptide Deformylase Mitochondrial, Human	1
DEF_ECOLI	P0A6K3	CHEMBL4976	Peptide Deformylase, Ecoli	1
DEF_STAAM	P68825	CHEMBL2367	Peptide Deformylase, Staam	1
ECE1_HUMAN	P42892	CHEMBL4791	Endothelin-converting Enzyme 1, Human	1
FCER2_HUMAN	P06734	CHEMBL2940	Immunoglobulin Epsilon Fc Receptor, Human	1
MMP12_RAT	Q63341	CHEMBL5506	Macrophage Metalloelastase, Rat	1
MMP13_BOVIN	O77656	CHEMBL5327	Matrix Metalloproteinase 13, Bovin	1
MMP17_HUMAN	Q9ULZ9	CHEMBL2937	Matrix Metalloproteinase 17, Human	1
MMP26_HUMAN	Q9NRE1	CHEMBL4707	Matrix Metalloproteinase 26, Human	1
MMP2_MOUSE	P33434	CHEMBL3095	Matrix Metalloproteinase-2, Mouse	1
MMP8_RAT	O88766	CHEMBL2312	Matrix Metalloproteinase 8, Rat	1
MMP9_MOUSE	P41245	CHEMBL2214	Matrix Metalloproteinase 9, Mouse	1
MMP9_RAT	P50282	CHEMBL3870	Matrix Metalloproteinase 9, Rat	1
NEP_HUMAN	P08473	CHEMBL1944	Neprilysin, Human	1
Q72874_9HIV1	Q72874	CHEMBL243	Human Immunodeficiency Virus Type 1 Protease, 9hiv1	1
Q9JN24_ECOLX	Q9JN24	CHEMBL1795101	Peptide Deformylase, Ecolx	1
TIMP3_RAT	P48032	CHEMBL3881	Tissue Inhibitor Of Metalloproteinases-3, Rat	1
TNFA_HUMAN	P01375	CHEMBL1825	TNF-alpha, Human	1