UCSF

Matrix Metalloproteinase-2, Human (2,765 Compounds)

Swissprot:
MMP2_HUMAN
Stitch:
MMP2_HUMAN
UniProt:
P08253
ChEMBL:
CHEMBL333
Reactome:
REACT_118682
REACT_150401
REACT_118572
REACT_228189
REACT_15428
PDB:
1CK7 (DOCK)
1CXW (DOCK)
1EAK (DOCK)
1GEN (DOCK)
1GXD (DOCK)
1HOV (DOCK)
1J7M (DOCK)
1KS0 (DOCK)
1QIB (DOCK)
1RTG (DOCK)
3AYU (DOCK)
MMP2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,765 37 17 44
Binding ≤ 1μM 2,262 22 6 32
Functional ≤ 10μM 4 0 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_228189 EPH-ephrin mediated repulsion of cells Homo sapiens
REACT_15428 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 59
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 62
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1087
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 381
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 28
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 60
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 11
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 999
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1109
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 275
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 641
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1387

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 135
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 268
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 3
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 59
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 62
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 126
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1087
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 381
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 28
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 999
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1109
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 275
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 641
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1387

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 135
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 58
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 35
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 4
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 59
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 62
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 126
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1087
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 381
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 28
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 999
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1109
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 275
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 641
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1387

EPH-ephrin mediated repulsion of cells

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 135
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1387

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l

Uniprot Swissprot Chembl Description Number Shared
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 999
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 3 0 0 1
MMP2_RAT P33436 CHEMBL1075175 72 KDa Type IV Collagenase, Rat 1 0 1 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 30 1 1 3
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MMP2-1-E 72 KDa Type IV Collagenase (cluster #1 Of 3), Eukaryotic 2,665 34 12 41
MMP2-2-E 72 KDa Type IV Collagenase (cluster #2 Of 3), Eukaryotic 112 8 7 5
MMP2-3-E 72 KDa Type IV Collagenase (cluster #3 Of 3), Eukaryotic 20 1 1 0
Uniprot Swissprot Chembl Description Number Shared
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1387
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 1109
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 1087
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 999
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 641
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 381
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 275
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 250
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 135
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 126
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 67
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 66
MMP11_MOUSE Q02853 CHEMBL3412 Matrix Metalloproteinase 11, Mouse 65
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 63
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 62
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 60
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 59
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 58
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 54
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 51
COLA_CLOPE P43153 CHEMBL2802 Microbial Collagenase, Clope 36
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 35
MMP15_HUMAN P51511 CHEMBL2963 Matrix Metalloproteinase 15, Human 28
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23
MMP13_BOVIN O77656 CHEMBL5327 Matrix Metalloproteinase 13, Bovin 22
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 17
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 16
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 16
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 16
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 16
MMP13_RAT P23097 CHEMBL4944 Matrix Metalloproteinase 13, Rat 12
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 11
MMP12_MOUSE P34960 CHEMBL2594 Matrix Metalloproteinase 12, Mouse 8
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 4
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 3
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 3
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 3
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 3
MMP2_MOUSE P33434 CHEMBL3095 Matrix Metalloproteinase-2, Mouse 3
MMP9_MOUSE P41245 CHEMBL2214 Matrix Metalloproteinase 9, Mouse 3
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 2
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 2
ATS5_BOVIN Q9TT92 CHEMBL2673 ADAMTS5, Bovin 2
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 2
FCER2_HUMAN P06734 CHEMBL2940 Immunoglobulin Epsilon Fc Receptor, Human 2
MMP12_RAT Q63341 CHEMBL5506 Macrophage Metalloelastase, Rat 2
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 2
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 2
TOP2A_HUMAN P11388 CHEMBL1806 DNA Topoisomerase II Alpha, Human 2
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 2
6PGD_HUMAN P52209 CHEMBL3404 6-phosphogluconate Dehydrogenase, Human 1
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA17_MOUSE Q9Z0F8 CHEMBL4379 ADAM17, Mouse 1
ADAM8_HUMAN P78325 CHEMBL5665 Disintegrin And Metalloproteinase Domain-containing Protein 8, Human 1
AMP1_PLAFQ O96935 CHEMBL4117 Zinc Aminopeptidase, Plafq 1
AMPB_MOUSE Q8VCT3 CHEMBL2836 Aminopeptidase B, Mouse 1
AMPB_RAT O09175 CHEMBL2452 Aminopeptidase B, Rat 1
AMPL_BOVIN P00727 CHEMBL1671610 Cytosol Aminopeptidase, Bovin 1
AMPL_HUMAN P28838 CHEMBL3965 Leucine Aminopeptidase, Human 1
ATS4_BOVIN Q9TT93 CHEMBL3874 ADAMTS4, Bovin 1
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 1
DEF1A_ARATH Q9FV53 CHEMBL1075041 Peptide Deformylase 1A, Chloroplastic, Arath 1
DEFM_HUMAN Q9HBH1 CHEMBL4647 Peptide Deformylase Mitochondrial, Human 1
DEF_STAAM P68825 CHEMBL2367 Peptide Deformylase, Staam 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
ERG1_RAT P52020 CHEMBL4241 Squalene Monooxygenase, Rat 1
G6PD_YEAST P11412 CHEMBL1075249 Glucose-6-phosphate 1-dehydrogenase, Yeast 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LCAP_RAT P97629 CHEMBL3712 Cystinyl Aminopeptidase, Rat 1
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
Q72547_9HIV1 Q72547 CHEMBL247 Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
Q9JN24_ECOLX Q9JN24 CHEMBL1795101 Peptide Deformylase, Ecolx 1
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1

Most Common Rings