UCSF

Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 (2,159 Compounds)

Swissprot:
Q72547_9HIV1
Stitch:
Q72547_9HIV1
UniProt:
Q72547
ChEMBL:
CHEMBL247
PDB:
2JLE (DOCK)
3HYF (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,159 77 25 39
Binding ≤ 1μM 1,540 53 20 35
Functional ≤ 10μM 218 6 5 9

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 4,810 37 27 40
Q77YF8_9HIV1 Q77YF8 CHEMBL3852 Human Immunodeficiency Virus Type 1 REV, 9hiv1 12 0 0 0
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 464 78 45 16
Q993A8_9HIV1 Q993A8 CHEMBL3022 Envelope Polyprotein GP120, 9hiv1 4 0 0 0

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
Q72547-1-V Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #1 Of 6), Viral 2,020 73 23 36
Q72547-2-V Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #2 Of 6), Viral 41 1 0 2
Q72547-3-V Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #3 Of 6), Viral 13 0 0 0
Q72547-4-V Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #4 Of 6), Viral 12 1 1 2
Q72547-5-V Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #5 Of 6), Viral 87 2 0 1
Q72547-6-V Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #6 Of 6), Viral 1 1 1 1
Uniprot Swissprot Chembl Description Number Shared
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 160
Z80295 Z80295 CHEMBL388 MT4 (Lymphocytes) 75
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 46
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 23
Z80076 Z80076 CHEMBL614548 CEM-SS (T-cell Leukemia) 22
DPOG1_HUMAN P54098 CHEMBL2732 DNA Polymerase Gamma Subunit 1, Human 16
DPOLB_HUMAN P06746 CHEMBL2392 DNA Polymerase Beta, Human 16
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 16
Z50606 Z50606 CHEMBL613497 Hepatitis B Virus 13
DPOLA_HUMAN P09884 CHEMBL1828 DNA Polymerase Alpha Subunit, Human 12
Z50677 Z50677 CHEMBL613758 Human Immunodeficiency Virus 7
Z80897 Z80897 CHEMBL614806 H9 (T-lymphoid Cells) 7
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 5
Z80052 Z80052 CHEMBL614533 C8166 (Leukemic T-cells) 5
Z80566 Z80566 CHEMBL612794 U-937 (Histiocytic Lymphoma Cells) 5
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 5
Z50658 Z50658 CHEMBL380 Human Immunodeficiency Virus 2 4
Z80294 Z80294 CHEMBL614184 MT2 (Lymphocytes) 4
6PGD_HUMAN P52209 CHEMBL3404 6-phosphogluconate Dehydrogenase, Human 2
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 2
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 2
DPOL_VZVD P09252 CHEMBL4859 DNA Polymerase, Vzvd 2
G6PD_YEAST P11412 CHEMBL1075249 Glucose-6-phosphate 1-dehydrogenase, Yeast 2
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 2
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 2
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 1
DPOD1_HUMAN P28340 CHEMBL2735 DNA Polymerase Delta Subunit 1, Human 1
DPOL_HCMVA P08546 CHEMBL3414 Human Herpesvirus 5 DNA Polymerase, Hcmva 1
DPOL_HHV11 P04293 CHEMBL1872 Human Herpesvirus 1 DNA Polymerase, Hhv11 1
DPOL_HHV1K P04292 CHEMBL5944 DNA Polymerase Catalytic Subunit, Hhv1k 1
ERG1_RAT P52020 CHEMBL4241 Squalene Monooxygenase, Rat 1
FABI_ECOLI P0AEK4 CHEMBL1857 Enoyl-[acyl-carrier-protein] Reductase, Ecoli 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
KITH_HUMAN P04183 CHEMBL2883 Thymidine Kinase, Cytosolic, Human 1
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 1
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
TYRO_HUMAN P14679 CHEMBL1973 Tyrosinase, Human 1
Z102020 Z102020 CHEMBL613016 Porcine Endogenous Retrovirus 1
Z50459 Z50459 CHEMBL367 Leishmania Donovani 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50602 Z50602 CHEMBL377 Human Herpesvirus 1 1
Z50609 Z50609 CHEMBL613499 Simian Immunodeficiency Virus 1
Z50613 Z50613 CHEMBL613550 Avian Myeloblastosis Virus 1
Z50624 Z50624 CHEMBL613715 Human Adenovirus Type 2 1
Z50664 Z50664 CHEMBL613748 Rauscher Murine Leukemia Virus 1
Z50737 Z50737 CHEMBL612359 Human Immunodeficiency Virus 3 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80071 Z80071 CHEMBL614028 CEM-0 (T-cell Leukemia) 1
Z80073 Z80073 CHEMBL614545 CEM-c113 1
Z80079 Z80079 CHEMBL614549 CEM-V 1
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 1
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 1
Z80384 Z80384 CHEMBL614233 PBL (Peripheral Blood Lymphocytes) 1
Z80516 Z80516 CHEMBL614940 SUP-T1 1
Z80683 Z80683 CHEMBL614272 ATH8 Cell Line 1
Z80688 Z80688 CHEMBL614797 B(EBV+) Cell Line 1
Z80721 Z80721 CHEMBL614366 BxT Cell Line 1
Z80737 Z80737 CHEMBL614372 C3H/3T3 (Embryonic Fibroblast Cells) 1
Z80760 Z80760 CHEMBL614779 CFU-GM Cell Line 1
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 1
Z81223 Z81223 CHEMBL614115 M Cell Line 1

Most Common Rings