UCSF

Neprilysin, Human (912 Compounds)

Swissprot:
NEP_HUMAN
Stitch:
NEP_HUMAN
UniProt:
P08473
ChEMBL:
CHEMBL1944
Reactome:
REACT_147707
PDB:
1DL9 (DOCK)
1DMT (DOCK)
1QVD (DOCK)
1R1H (DOCK)
1R1I (DOCK)
1R1J (DOCK)
1Y8J (DOCK)
2QPJ (DOCK)
2YB9 (DOCK)
MME

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 912 5 7 19
Binding ≤ 1μM 821 3 6 17

Reactome Network (1)

Reactome ID Description Species
REACT_147707 Metabolism of Angiotensinogen to Angiotensins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 34
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 202
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 13
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 117
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NEP_MOUSE Q61391 CHEMBL2642 Neprilysin, Mouse 18 8 0 0
NEP_PIG P19621 CHEMBL6107 Neprilysin, Pig 34 2 2 2
NEP_RABIT P08049 CHEMBL3768 Neprilysin, Rabit 78 0 0 1
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 545 4 7 11

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
NEP-1-E Neprilysin (cluster #1 Of 2), Eukaryotic 289 2 0 5
NEP-2-E Neprilysin (cluster #2 Of 2), Eukaryotic 1,310 14 11 20
Uniprot Swissprot Chembl Description Number Shared
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 218
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 202
ACE_RAT P47820 CHEMBL2625 Angiotensin-converting Enzyme, Rat 180
AMPN_HUMAN P15144 CHEMBL1907 Aminopeptidase N, Human 117
ACE_MOUSE P09470 CHEMBL2994 Angiotensin-converting Enzyme, Mouse 88
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 46
THER_BACTH P00800 CHEMBL3392 Thermolysin, Bacth 40
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 39
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 34
DPP3_RAT O55096 CHEMBL2233 Dipeptidyl Peptidase III, Rat 25
DPP2_RAT Q9EPB1 CHEMBL4352 Dipeptidyl Peptidase II, Rat 23
DPP6_RAT P46101 CHEMBL4353 Dipeptidyl Peptidase VI, Rat 23
AMPE_PIG Q95334 CHEMBL4868 Aminopeptidase A, Pig 21
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 13
ANF_HUMAN P01160 CHEMBL1293193 Atrial Natriuretic Factor, Human 11
NEP_PIG P19621 CHEMBL6107 Neprilysin, Pig 10
DPP4_RAT P14740 CHEMBL4653 Dipeptidyl Peptidase IV, Rat 9
NEP_RABIT P08049 CHEMBL3768 Neprilysin, Rabit 8
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 5
AMPB_HUMAN Q9H4A4 CHEMBL2432 Aminopeptidase B, Human 3
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 3
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 2
ECE1_RAT P42893 CHEMBL2676 Endothelin-converting Enzyme 1, Rat 2
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 1
DEF1A_ARATH Q9FV53 CHEMBL1075041 Peptide Deformylase 1A, Chloroplastic, Arath 1
DEFM_HUMAN Q9HBH1 CHEMBL4647 Peptide Deformylase Mitochondrial, Human 1
DEF_ECOLI P0A6K3 CHEMBL4976 Peptide Deformylase, Ecoli 1
DEF_STAAM P68825 CHEMBL2367 Peptide Deformylase, Staam 1
ECE1_BOVIN P42891 CHEMBL2340 Endothelin-converting Enzyme 1, Bovin 1
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 1
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 1
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 1
Q9JN24_ECOLX Q9JN24 CHEMBL1795101 Peptide Deformylase, Ecolx 1

Most Common Rings