UCSF

Aminopeptidase N, Human (297 Compounds)

Swissprot:
AMPN_HUMAN
Stitch:
AMPN_HUMAN
UniProt:
P15144
ChEMBL:
CHEMBL1907
Reactome:
REACT_147707
PDB:
ANPEP

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 297 4 3 9
Binding ≤ 1μM 213 2 1 7

Reactome Network (1)

Reactome ID Description Species
REACT_147707 Metabolism of Angiotensinogen to Angiotensins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 1
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 2
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 42
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 117
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AMPN_ECOLI P04825 CHEMBL4325 Aminopeptidase N, Ecoli 9 0 0 0
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 272 4 1 5
AMPN_RAT P15684 CHEMBL3259 Aminopeptidase N, Rat 1 0 0 0

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
AMPN-1-B Aminopeptidase N (cluster #1 Of 1), Bacterial 9 0 0 0
AMPN-1-E Aminopeptidase N (cluster #1 Of 5), Eukaryotic 51 3 1 1
AMPN-2-E Aminopeptidase N (cluster #2 Of 5), Eukaryotic 403 2 2 11
AMPN-3-E Aminopeptidase N (cluster #3 Of 5), Eukaryotic 28 0 0 0
AMPN-4-E Aminopeptidase N (cluster #4 Of 5), Eukaryotic 0 0 0 0
AMPN-5-E Aminopeptidase N (cluster #5 Of 5), Eukaryotic 94 2 0 3
Uniprot Swissprot Chembl Description Number Shared
NEP_HUMAN P08473 CHEMBL1944 Neprilysin, Human 117
AMPE_HUMAN Q07075 CHEMBL3439 Aminopeptidase A, Human 42
AMPL_HUMAN P28838 CHEMBL3965 Leucine Aminopeptidase, Human 29
AMPN_PIG P15145 CHEMBL2590 Aminopeptidase N, Pig 29
ACE_RAT P47820 CHEMBL2625 Angiotensin-converting Enzyme, Rat 15
LCAP_HUMAN Q9UIQ6 CHEMBL2693 Cystinyl Aminopeptidase, Human 14
AMPB_HUMAN Q9H4A4 CHEMBL2432 Aminopeptidase B, Human 13
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 12
AMPB_RAT O09175 CHEMBL2452 Aminopeptidase B, Rat 7
AMP1_PLAFQ O96935 CHEMBL4117 Zinc Aminopeptidase, Plafq 6
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 2
DNPEP_HUMAN Q9ULA0 CHEMBL2761 Aspartyl Aminopeptidase, Human 2
LCAP_RAT P97629 CHEMBL3712 Cystinyl Aminopeptidase, Rat 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2
ACE2_HUMAN Q9BYF1 CHEMBL3736 Angiotensin-converting Enzyme 2, Human 1
ACE_RABIT P12822 CHEMBL4074 Angiotensin-converting Enzyme, Rabit 1
AMPB_MOUSE Q8VCT3 CHEMBL2836 Aminopeptidase B, Mouse 1
AMPE_PIG Q95334 CHEMBL4868 Aminopeptidase A, Pig 1
AMPL_BOVIN P00727 CHEMBL1671610 Cytosol Aminopeptidase, Bovin 1
DAPE_HAEIN P44514 CHEMBL1075192 Succinyl-diaminopimelate Desuccinylase, Haein 1
DPP2_RAT Q9EPB1 CHEMBL4352 Dipeptidyl Peptidase II, Rat 1
DPP3_RAT O55096 CHEMBL2233 Dipeptidyl Peptidase III, Rat 1
DPP4_RAT P14740 CHEMBL4653 Dipeptidyl Peptidase IV, Rat 1
DPP6_RAT P46101 CHEMBL4353 Dipeptidyl Peptidase VI, Rat 1
ECE1_HUMAN P42892 CHEMBL4791 Endothelin-converting Enzyme 1, Human 1
NEP_RAT P07861 CHEMBL3369 Neprilysin, Rat 1
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
THER_BACTH P00800 CHEMBL3392 Thermolysin, Bacth 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1

Most Common Rings