UCSF

Matrix Metalloproteinase 15, Human (30 Compounds)

Swissprot:
MMP15_HUMAN
Stitch:
MMP15_HUMAN
UniProt:
P51511
ChEMBL:
CHEMBL2963
Reactome:
REACT_118682
REACT_150401
REACT_118572
PDB:
MMP15

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 30 1 1 3
Binding ≤ 1μM 23 1 1 2

Reactome Network (3)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 3
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 5
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 27
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 29
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 19
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 28
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 6
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 11
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 6
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 27

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 1
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 4
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 3
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 26
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 5
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 27
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 19
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 28
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 6
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 11
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 6
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 27

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 1
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 1
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 1
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 1
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 3
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 26
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 5
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 27
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 19
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 28
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 6
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 11
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 6
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 27
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 82 1 1 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 71 1 1 1
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 289 8 4 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 2,513 43 6 37
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 507 9 8 14
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 61 3 1 4
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 29 1 1 1
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2,665 22 9 44
MMP25_HUMAN Q9NPA2 CHEMBL1795103 Matrix Metalloproteinase-25, Human 8 0 0 1
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23 1 1 2
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 2,765 37 17 44
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 2,212 22 9 40
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 467 10 4 22
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 980 16 6 25
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 2,243 31 11 34

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MMP16_HUMAN P51512 CHEMBL2200 Matrix Metalloproteinase 16, Human 29
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 28
MMP14_HUMAN P50281 CHEMBL3869 Matrix Metalloproteinase 14, Human 27
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 27
MMP12_HUMAN P39900 CHEMBL4393 Matrix Metalloproteinase 12, Human 26
MMP26_HUMAN Q9NRE1 CHEMBL4707 Matrix Metalloproteinase 26, Human 23
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 19
MMP7_HUMAN P09237 CHEMBL4073 Matrix Metalloproteinase 7, Human 11
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 6
MMP8_HUMAN P22894 CHEMBL4588 Matrix Metalloproteinase 8, Human 6
ADA17_PIG O77636 CHEMBL3332 ADAM17, Pig 5
MMP13_HUMAN P45452 CHEMBL280 Matrix Metalloproteinase 13, Human 5
MMP10_HUMAN P09238 CHEMBL4270 Matrix Metalloproteinase 10, Human 3
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 2
ADA10_HUMAN O14672 CHEMBL5028 ADAM10, Human 1
ADA12_HUMAN O43184 CHEMBL5030 ADAM12, Human 1
ADA33_HUMAN Q9BZ11 CHEMBL6121 Disintegrin And Metalloproteinase Domain-containing Protein 33, Human 1
ADAM9_HUMAN Q13443 CHEMBL5982 ADAM9, Human 1
ATS1_HUMAN Q9UHI8 CHEMBL5133 ADAMTS1, Human 1
ATS4_HUMAN O75173 CHEMBL2318 ADAMTS4, Human 1
ATS5_HUMAN Q9UNA0 CHEMBL2285 ADAMTS5, Human 1
MMP11_HUMAN P24347 CHEMBL2867 Matrix Metalloproteinase 11, Human 1
MMP17_HUMAN Q9ULZ9 CHEMBL2937 Matrix Metalloproteinase 17, Human 1
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 1