UCSF

Tyrosine-protein Kinase ABL, Mouse (8 Compounds)

Swissprot:
ABL1_MOUSE
Stitch:
ABL1_MOUSE
UniProt:
P00520
ChEMBL:
CHEMBL3099
Reactome:
REACT_258600
REACT_198649
REACT_198374
REACT_254504
PDB:
1ABO (DOCK)
1ABQ (DOCK)
1FPU (DOCK)
1IEP (DOCK)
1M52 (DOCK)
1OPJ (DOCK)
1OPK (DOCK)
2HZN (DOCK)
2QOH (DOCK)
2Z60 (DOCK)
3DK3 (DOCK)
3DK6 (DOCK)
3DK7 (DOCK)
3IK3 (DOCK)
3K5V (DOCK)
3KF4 (DOCK)
3KFA (DOCK)
3MS9 (DOCK)
3MSS (DOCK)
3OXZ (DOCK)
3OY3 (DOCK)
Abl1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 3 3 3
Binding ≤ 1μM 7 2 2 2

Reactome Network (4)

Reactome ID Description Species
REACT_258600 CDO in myogenesis Mus musculus
REACT_198649 Factors involved in megakaryocyte development and platelet production Mus musculus
REACT_198374 Regulation of actin dynamics for phagocytic cup formation Mus musculus
REACT_254504 Role of Abl in Robo-Slit signaling Mus musculus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 930 96 23 42
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ABL2_MOUSE Q4JIM5 CHEMBL5222 Tyrosine-protein Kinase ABL2, Mouse 2 1 1 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 6
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 5
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 3
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 3
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 2
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 2
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 2
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 2
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 2
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 2
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 2
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 2
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 2
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 2
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 2
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 2
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 2
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 2
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 2
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 2
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 2
A1Z199_HUMAN A1Z199 CHEMBL6105 BCR/ABL P210 Fusion Protein, Human 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 1
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 1
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK14_HUMAN O94921 CHEMBL6162 Serine/threonine-protein Kinase PFTAIRE-1, Human 1
CDK15_HUMAN Q96Q40 CHEMBL5856 Serine/threonine-protein Kinase PFTAIRE-2, Human 1
CDK17_HUMAN Q00537 CHEMBL5790 Serine/threonine-protein Kinase PCTAIRE-2, Human 1
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 1
CDKL2_HUMAN Q92772 CHEMBL5728 Cyclin-dependent Kinase-like 2, Human 1
CDKL3_HUMAN Q8IVW4 CHEMBL1163117 Cyclin-dependent Kinase-like 3, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 1
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 1
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 1
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 1
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 1
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 1
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 1
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 1
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 1
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 1
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 1
EPHB6_HUMAN O15197 CHEMBL5836 Ephrin Type-B Receptor 6, Human 1
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 1
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 1
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 1
HIPK1_HUMAN Q86Z02 CHEMBL5427 Homeodomain-interacting Protein Kinase 1, Human 1
HIPK2_HUMAN Q9H2X6 CHEMBL4576 Homeodomain-interacting Protein Kinase 2, Human 1
HIPK3_HUMAN Q9H422 CHEMBL4577 Homeodomain-interacting Protein Kinase 3, Human 1
HIPK4_HUMAN Q8NE63 CHEMBL1075167 Homeodomain-interacting Protein Kinase 4, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 1
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 1
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 1
MELK_HUMAN Q14680 CHEMBL4578 Maternal Embryonic Leucine Zipper Kinase, Human 1
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 1
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 1
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 1
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 1
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 1
MYLK2_HUMAN Q9H1R3 CHEMBL2777 Myosin Light Chain Kinase 2, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 Growth Factor Receptor, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1
RON_HUMAN Q04912 CHEMBL2689 Macrophage-stimulating Protein Receptor, Human 1
RON_MOUSE Q62190 CHEMBL1795170 Macrophage-stimulating Protein Receptor, Mouse 1
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 1
STK33_HUMAN Q9BYT3 CHEMBL6005 Serine/threonine-protein Kinase 33, Human 1
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 1
TAOK1_HUMAN Q7L7X3 CHEMBL5261 Serine/threonine-protein Kinase TAO1, Human 1
TAOK3_HUMAN Q9H2K8 CHEMBL5701 Serine/threonine-protein Kinase TAO3, Human 1
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 1
TIE2_MOUSE Q02858 CHEMBL5199 Tyrosine-protein Kinase TIE-2, Mouse 1
TNK1_HUMAN Q13470 CHEMBL5334 Non-receptor Tyrosine-protein Kinase TNK1, Human 1
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1
YSK4_HUMAN Q56UN5 CHEMBL6191 SPS1/STE20-related Protein Kinase YSK4, Human 1

Most Common Rings