UCSF

Ephrin Type-B Receptor 3, Human (21 Compounds)

Swissprot:
EPHB3_HUMAN
Stitch:
EPHB3_HUMAN
UniProt:
P54753
ChEMBL:
CHEMBL4901
Reactome:
REACT_228189
REACT_228170
REACT_228085
REACT_228226
PDB:
3P1I (DOCK)
EPHB3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 21 4 2 2
Binding ≤ 1μM 17 2 1 1

Reactome Network (4)

Reactome ID Description Species
REACT_228189 EPH-ephrin mediated repulsion of cells Homo sapiens
REACT_228170 EPH-Ephrin signaling Homo sapiens
REACT_228085 EPHB-mediated forward signaling Homo sapiens
REACT_228226 Ephrin signaling Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 4
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 4
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 5
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 4
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 4
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 3
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 3
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 3
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 4
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 4
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 3
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 3

EPH-Ephrin signaling

Uniprot Swissprot Chembl Description Number Shared
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 4
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 4
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 5
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 4
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 4
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 3
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 3
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 3
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 4
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 4
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 3
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 3

EPHB-mediated forward signaling

Uniprot Swissprot Chembl Description Number Shared
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 3
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 3
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 4
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 4
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 3
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 3

Ephrin signaling

Uniprot Swissprot Chembl Description Number Shared
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 3
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 3
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 4
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 17 14 10 11
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 21 13 7 11
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 332 21 10 23
EPHB6_HUMAN O15197 CHEMBL5836 Ephrin Type-B Receptor 6, Human 4 4 3 4

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 5
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 4
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 4
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 4
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 4
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 4
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 4
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 4
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 3
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 3
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 3
BMX_HUMAN P51813 CHEMBL3834 Tyrosine-protein Kinase BMX, Human 3
BTK_HUMAN Q06187 CHEMBL5251 Tyrosine-protein Kinase BTK, Human 3
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 3
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 3
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 3
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 3
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 3
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 3
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 3
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 3
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 3
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 3
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 3
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 3
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 3
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 3
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 3
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 3
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 2
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 2
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 2
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 2
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 2
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 2
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 2
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 2
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 2
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 2
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 2
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 2
LCK_MOUSE P06240 CHEMBL2480 Tyrosine-protein Kinase LCK, Mouse 2
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 2
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 2
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 2
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 2
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 2
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 2
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 2
SIK1_HUMAN P57059 CHEMBL6082 Serine/threonine-protein Kinase SIK1, Human 2
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 2
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 2
TEC_HUMAN P42680 CHEMBL4246 Tyrosine-protein Kinase TEC, Human 2
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 2
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 2
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 2
TYRO3_HUMAN Q06418 CHEMBL5314 Tyrosine-protein Kinase Receptor TYRO3, Human 2
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 2
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 2
ACK1_HUMAN Q07912 CHEMBL4599 Tyrosine Kinase Non-receptor Protein 2, Human 1
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 1
ACVL1_HUMAN P37023 CHEMBL5311 Serine/threonine-protein Kinase Receptor R3, Human 1
ACVR1_HUMAN Q04771 CHEMBL5903 Activin Receptor Type-1, Human 1
ADCK3_HUMAN Q8NI60 CHEMBL5550 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 1
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 1
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
AURKA_MOUSE P97477 CHEMBL2211 Serine/threonine-protein Kinase Aurora-A, Mouse 1
AURKB_MOUSE O70126 CHEMBL1075275 Serine/threonine-protein Kinase 12, Mouse 1
AVR2A_HUMAN P27037 CHEMBL5616 Activin Receptor Type-2A, Human 1
AVR2B_HUMAN Q13705 CHEMBL5466 Activin Receptor Type-2B, Human 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
BLK_MOUSE P16277 CHEMBL3343 Tyrosine-protein Kinase BLK, Mouse 1
BMPR2_HUMAN Q13873 CHEMBL5467 Bone Morphogenetic Protein Receptor Type-2, Human 1
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CD11A_HUMAN Q9UQ88 CHEMBL5416 PITSLRE Serine/threonine-protein Kinase CDC2L2, Human 1
CD11B_HUMAN P21127 CHEMBL5808 PITSLRE Serine/threonine-protein Kinase CDC2L1, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 1
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK3_HUMAN P49761 CHEMBL4226 Dual Specificity Protein Kinase CLK3, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 1
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 1
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 1
FAK2_HUMAN Q14289 CHEMBL5469 Protein Tyrosine Kinase 2 Beta, Human 1
FER_HUMAN P16591 CHEMBL3982 Tyrosine-protein Kinase FER, Human 1
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 1
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 1
INSRR_HUMAN P14616 CHEMBL5483 Insulin Receptor-related Protein, Human 1
IRAK3_HUMAN Q9Y616 CHEMBL5081 Interleukin-1 Receptor-associated Kinase 3, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 1
KS6A5_HUMAN O75582 CHEMBL4237 Ribosomal Protein S6 Kinase Alpha 5, Human 1
LATS2_HUMAN Q9NRM7 CHEMBL5907 Serine/threonine-protein Kinase LATS2, Human 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LTK_HUMAN P29376 CHEMBL5627 Leukocyte Tyrosine Kinase Receptor, Human 1
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 1
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 1
MAPK5_HUMAN Q8IW41 CHEMBL3094 MAP Kinase-activated Protein Kinase 5, Human 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 1
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 1
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 1
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 1
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 1
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 1
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 Growth Factor Receptor, Human 1
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 1
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 1
PMYT1_HUMAN Q99640 CHEMBL3984 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 1
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1
RIPK1_HUMAN Q13546 CHEMBL5464 Receptor-interacting Serine/threonine-protein Kinase 1, Human 1
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1
ROS1_HUMAN P08922 CHEMBL5568 Proto-oncogene Tyrosine-protein Kinase ROS, Human 1
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 1
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
ST17B_HUMAN O94768 CHEMBL3980 Serine/threonine-protein Kinase 17B, Human 1
ST32B_HUMAN Q9NY57 CHEMBL5912 Serine/threonine-protein Kinase 32B, Human 1
STK33_HUMAN Q9BYT3 CHEMBL6005 Serine/threonine-protein Kinase 33, Human 1
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 1
STK3_HUMAN Q13188 CHEMBL4708 Serine/threonine-protein Kinase MST2, Human 1
STK4_HUMAN Q13043 CHEMBL4598 Serine/threonine-protein Kinase MST1, Human 1
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 1
TESK1_HUMAN Q15569 CHEMBL5604 Dual Specificity Testis-specific Protein Kinase 1, Human 1
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 1
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 1
TNK1_HUMAN Q13470 CHEMBL5334 Non-receptor Tyrosine-protein Kinase TNK1, Human 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1

Most Common Rings