UCSF

Trypsin I, Human (1,764 Compounds)

Swissprot:
TRY1_HUMAN
Stitch:
TRY1_HUMAN
UniProt:
P07477
ChEMBL:
CHEMBL209
Reactome:
REACT_118682
REACT_163862
PDB:
1FXY (DOCK)
1TRN (DOCK)
2RA3 (DOCK)
PRSS1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,764 48 13 44
Binding ≤ 1μM 1,050 9 4 29

Reactome Network (2)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_163862 Cobalamin (Cbl, vitamin B12) transport and metabolism Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 41
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 34
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 36
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 8
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 24
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 195
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 414
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 87

Cobalamin (Cbl, vitamin B12) transport and metabolism

Uniprot Swissprot Chembl Description Number Shared
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 36
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 101
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 405 7 5 12
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 415 34 2 6
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 101 1 0 0
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 397 1 0 2
TRYD_HUMAN Q9BZJ3 CHEMBL2402 Tryptase Delta, Human 231 1 0 1
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 225 1 0 1

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
TRY1-1-E Trypsin I (cluster #1 Of 5), Eukaryotic 1,015 13 8 39
TRY1-2-E Trypsin I (cluster #2 Of 5), Eukaryotic 2 2 1 1
TRY1-3-E Trypsin I (cluster #3 Of 5), Eukaryotic 807 4 6 9
TRY1-4-E Trypsin I (cluster #4 Of 5), Eukaryotic 325 32 1 2
TRY1-5-E Trypsin I (cluster #5 Of 5), Eukaryotic 5 0 0 0
Uniprot Swissprot Chembl Description Number Shared
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1226
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 968
TRY2_HUMAN P07478 CHEMBL3159 Trypsin II, Human 414
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 195
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 117
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 112
TRY3_HUMAN P35030 CHEMBL4551 Trypsin III, Human 101
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 87
FA7_HUMAN P08709 CHEMBL3991 Coagulation Factor VII, Human 69
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 41
CEL2A_PIG P08419 CHEMBL2407 Elastase 2A, Pig 40
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 37
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 36
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 34
TRYD_HUMAN Q9BZJ3 CHEMBL2402 Tryptase Delta, Human 34
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 34
KLK1_HUMAN P06870 CHEMBL2319 Kallikrein 1, Human 33
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 33
PLMN_RAT Q01177 CHEMBL3204 Plasminogen, Rat 25
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 24
FA9_HUMAN P00740 CHEMBL2016 Coagulation Factor IX, Human 19
THRB_BOVIN P00735 CHEMBL4471 Thrombin, Bovin 11
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 11
CTRB_BOVIN P00767 CHEMBL3063 Beta-chymotrypsin, Bovin 9
FA10_BOVIN P00743 CHEMBL3656 Coagulation Factor X, Bovin 8
KLK10_HUMAN O43240 CHEMBL4180 Kallikrein 10, Human 8
KLK11_HUMAN Q9UBX7 CHEMBL3031 Kallikrein 11, Human 8
KLK12_HUMAN Q9UKR0 CHEMBL4943 Kallikrein 12, Human 8
KLK13_HUMAN Q9UKR3 CHEMBL4863 Kallikrein 13, Human 8
KLK14_HUMAN Q9P0G3 CHEMBL2641 Kallikrein 14, Human 8
KLK15_HUMAN Q9H2R5 CHEMBL2174 Kallikrein 15, Human 8
KLK2_HUMAN P20151 CHEMBL2442 Kallikrein 2, Human 8
KLK3_HUMAN P07288 CHEMBL2099 Prostate Specific Antigen, Human 8
KLK4_HUMAN Q9Y5K2 CHEMBL4446 Kallikrein 4, Human 8
KLK5_HUMAN Q9Y337 CHEMBL4447 Kallikrein 5, Human 8
KLK6_HUMAN Q92876 CHEMBL4448 Kallikrein 6, Human 8
KLK7_HUMAN P49862 CHEMBL2443 Kallikrein 7, Human 8
KLK8_HUMAN O60259 CHEMBL4812 Kallikrein 8, Human 8
KLK9_HUMAN Q9UKQ9 CHEMBL3029 Kallikrein 9, Human 8
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 7
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 7
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 7
C1R_HUMAN P00736 CHEMBL4611 Complement C1r, Human 6
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 6
CTRC_HUMAN Q99895 CHEMBL2386 Chymotrypsin C, Human 6
THRB_RAT P18292 CHEMBL3078 Thrombin, Rat 5
C1S_HUMAN P09871 CHEMBL3913 Complement C1s, Human 4
FA10_RAT Q63207 CHEMBL3755 Coagulation Factor X, Rat 4
O77669_CANFA O77669 CHEMBL3929 Coagulation Factor X, Canine 4
APOH_HUMAN P02749 CHEMBL2859 Apolipoprotein H, Human 3
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 3
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 3
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 3
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 3
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 3
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 3
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 3
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 3
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 3
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 3
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 3
TRYP_PIG P00761 CHEMBL2366 Trypsin, Pig 3
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 2
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 2
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
ANT3_HUMAN P01008 CHEMBL1950 Antithrombin-III Precursor, Human 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
S100B_HUMAN P04271 CHEMBL4300 S-100 Protein Beta Chain, Human 1
T2AG_HUMAN P52657 CHEMBL4283 Transcription Initiation Factor IIA Gamma Chain, Human 1
TRY2_RAT P00763 CHEMBL4290 Trypsin II, Rat 1
TRYB1_MOUSE Q02844 CHEMBL4749 Tryptase Alpha/beta-1, Mouse 1
TRYB1_RAT P27435 CHEMBL3320 Tryptase Alpha/beta-1, Rat 1
TRYT_CANFA P15944 CHEMBL4700 Tryptase, Canine 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 1

Most Common Rings