ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (832)
Reactome (1)
Related By:
Pathway (3)
Organism (3)
Gene (0)
Org. Clust. (3)
ChEMBL (57)
Rings (18)

Urokinase-type Plasminogen Activator, Human (832 Compounds)

Swissprot:: UROK_HUMAN
Stitch:: UROK_HUMAN
UniProt:: P00749
ChEMBL:: CHEMBL3286
Reactome:: REACT_641
PDB:: 1C5W (DOCK); 1C5X (DOCK); 1C5Y (DOCK); 1C5Z (DOCK); 1EJN (DOCK); 1F5K (DOCK); 1F5L (DOCK); 1F92 (DOCK); 1FV9 (DOCK); 1GI7 (DOCK); 1GI8 (DOCK); 1GI9 (DOCK); 1GJ7 (DOCK); 1GJ8 (DOCK); 1GJ9 (DOCK); 1GJA (DOCK); 1GJB (DOCK); 1GJC (DOCK); 1GJD (DOCK); 1KDU (DOCK); 1LMW (DOCK); 1O3P (DOCK); 1O5A (DOCK); 1O5B (DOCK); 1O5C (DOCK); 1OWD (DOCK); 1OWE (DOCK); 1OWH (DOCK); 1OWI (DOCK); 1OWJ (DOCK); 1OWK (DOCK); 1SC8 (DOCK); 1SQA (DOCK); 1SQO (DOCK); 1SQT (DOCK); 1U6Q (DOCK); 1URK (DOCK); 1VJ9 (DOCK); 1VJA (DOCK); 1W0Z (DOCK); 1W10 (DOCK); 1W11 (DOCK); 1W12 (DOCK); 1W13 (DOCK); 1W14 (DOCK); 2FD6 (DOCK); 2I9A (DOCK); 2I9B (DOCK); 2NWN (DOCK); 2O8T (DOCK); 2O8U (DOCK); 2O8W (DOCK); 2R2W (DOCK); 2VIN (DOCK); 2VIO (DOCK); 2VIP (DOCK); 2VIQ (DOCK); 2VIV (DOCK); 2VIW (DOCK); 2VNT (DOCK); 3BT1 (DOCK); 3BT2 (DOCK); 3IG6 (DOCK); 3KGP (DOCK); 3KHV (DOCK); 3KID (DOCK); 3M61 (DOCK); 3MHW (DOCK); 3MWI (DOCK); 3OX7 (DOCK); 3OY5 (DOCK); 3OY6 (DOCK); 3PB1 (DOCK); PLAU

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	832	26	3	35
Binding ≤ 1μM	543	3	0	23

Reactome ID	Description	Species
REACT_641	Dissolution of Fibrin Clot	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PLMN_HUMAN	P00747	CHEMBL1801	Plasminogen, Human	307
TPA_HUMAN	P00750	CHEMBL1873	Tissue-type Plasminogen Activator, Human	130
UPAR_HUMAN	Q03405	CHEMBL4883	Urokinase Plasminogen Activator Surface Receptor, Human	3

UniProt	Swissprot	ChEMBL	Description	Substances
UROK_MOUSE	P06869	CHEMBL1075311	Urokinase-type Plasminogen Activator, Mouse	4
UROK_PIG	P04185	CHEMBL1075030	Urokinase-type Plasminogen Activator, Pig	2
UROK_RAT	P29598	CHEMBL1075245	Urokinase-type Plasminogen Activator, Rat	4

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
UROK-1-E	Urokinase-type Plasminogen Activator (cluster #1 Of 4), Eukaryotic	242	13	2	27
UROK-2-E	Urokinase-type Plasminogen Activator (cluster #2 Of 4), Eukaryotic	512	9	0	6
UROK-3-E	Urokinase-type Plasminogen Activator (cluster #3 Of 4), Eukaryotic	22	0	0	1
UROK-4-E	Urokinase-type Plasminogen Activator (cluster #4 Of 4), Eukaryotic	57	4	1	1

Uniprot	Swissprot	Chembl	Description	Number Shared
PLMN_HUMAN	P00747	CHEMBL1801	Plasminogen, Human	307
THRB_HUMAN	P00734	CHEMBL204	Thrombin, Human	225
FA10_HUMAN	P00742	CHEMBL244	Coagulation Factor X, Human	221
TPA_HUMAN	P00750	CHEMBL1873	Tissue-type Plasminogen Activator, Human	130
TRY1_HUMAN	P07477	CHEMBL209	Trypsin I, Human	117
FA9_HUMAN	P00740	CHEMBL2016	Coagulation Factor IX, Human	96
ST14_HUMAN	Q9Y5Y6	CHEMBL3018	Matriptase, Human	87
TRY1_BOVIN	P00760	CHEMBL3769	Trypsin I, Bovin	65
TRY2_BOVIN	Q29463	CHEMBL4472	Trypsin II, Bovin	62
KLK1_HUMAN	P06870	CHEMBL2319	Kallikrein 1, Human	39
THRB_RAT	P18292	CHEMBL3078	Thrombin, Rat	27
TRYP_PIG	P00761	CHEMBL2366	Trypsin, Pig	27
KLKB1_HUMAN	P03952	CHEMBL2000	Plasma Kallikrein, Human	26
ELNE_HUMAN	P08246	CHEMBL248	Leukocyte Elastase, Human	19
FA7_HUMAN	P08709	CHEMBL3991	Coagulation Factor VII, Human	19
THRB_BOVIN	P00735	CHEMBL4471	Thrombin, Bovin	17
PLMN_RAT	Q01177	CHEMBL3204	Plasminogen, Rat	13
FA10_BOVIN	P00743	CHEMBL3656	Coagulation Factor X, Bovin	12
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	7
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	7
TRY2_HUMAN	P07478	CHEMBL3159	Trypsin II, Human	6
TRYB1_HUMAN	Q15661	CHEMBL2617	Tryptase Beta-1, Human	6
TRYG1_HUMAN	Q9NRR2	CHEMBL4955	Tryptase Gamma, Human	6
KPCA_HUMAN	P17252	CHEMBL299	Protein Kinase C Alpha, Human	5
KPCB_HUMAN	P05771	CHEMBL3045	Protein Kinase C Beta, Human	5
KPCD1_HUMAN	Q15139	CHEMBL3863	Protein Kinase C Mu, Human	5
KPCD3_HUMAN	O94806	CHEMBL2595	Protein Kinase C Nu, Human	5
KPCD_HUMAN	Q05655	CHEMBL2996	Protein Kinase C Delta, Human	5
KPCE_HUMAN	Q02156	CHEMBL3582	Protein Kinase C Epsilon, Human	5
KPCG_HUMAN	P05129	CHEMBL2938	Protein Kinase C Gamma, Human	5
KPCI_HUMAN	P41743	CHEMBL2598	Protein Kinase C Iota, Human	5
KPCL_HUMAN	P24723	CHEMBL3616	Protein Kinase C Eta, Human	5
KPCT_HUMAN	Q04759	CHEMBL3920	Protein Kinase C Theta, Human	5
KPCZ_HUMAN	Q05513	CHEMBL3438	Protein Kinase C Zeta, Human	5
TRYD_HUMAN	Q9BZJ3	CHEMBL2402	Tryptase Delta, Human	5
C1S_HUMAN	P09871	CHEMBL3913	Complement C1s, Human	4
O77669_CANFA	O77669	CHEMBL3929	Coagulation Factor X, Canine	4
UROK_MOUSE	P06869	CHEMBL1075311	Urokinase-type Plasminogen Activator, Mouse	4
UROK_RAT	P29598	CHEMBL1075245	Urokinase-type Plasminogen Activator, Rat	4
UPAR_HUMAN	Q03405	CHEMBL4883	Urokinase Plasminogen Activator Surface Receptor, Human	3
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) Receptor, Human	2
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) Receptor, Human	2
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) Receptor, Human	2
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) Receptor, Human	2
CTRA_BOVIN	P00766	CHEMBL3314	Alpha-chymotrypsin, Bovin	2
PLMN_MOUSE	P20918	CHEMBL1075299	Plasminogen, Mouse	2
THRB_MOUSE	P19221	CHEMBL1075308	Prothrombin, Mouse	2
UROK_PIG	P04185	CHEMBL1075030	Urokinase-type Plasminogen Activator, Pig	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	1
ACCN3_HUMAN	Q9UHC3	CHEMBL5368	Amiloride-sensitive Cation Channel 3, Human	1
AOC3_RAT	O08590	CHEMBL4592	Amine Oxidase, Copper Containing, Rat	1
SCNNA_HUMAN	P37088	CHEMBL1791	Amiloride-sensitive Sodium Channel Alpha-subunit, Human	1
T2AG_HUMAN	P52657	CHEMBL4283	Transcription Initiation Factor IIA Gamma Chain, Human	1
TF_HUMAN	P13726	CHEMBL4081	Coagulation Factor III, Human	1
TM11D_HUMAN	O60235	CHEMBL1795138	Transmembrane Protease Serine 11D, Human	1
TRY3_HUMAN	P35030	CHEMBL4551	Trypsin III, Human	1