UCSF

Leukocyte Elastase, Human (1,572 Compounds)

Swissprot:
ELNE_HUMAN
Stitch:
ELNE_HUMAN
UniProt:
P08246
ChEMBL:
CHEMBL248
Reactome:
REACT_118682
REACT_150401
REACT_118572
PDB:
1B0F (DOCK)
1H1B (DOCK)
1HNE (DOCK)
1PPF (DOCK)
1PPG (DOCK)
2RG3 (DOCK)
2Z7F (DOCK)
3Q76 (DOCK)
3Q77 (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,572 50 4 13
Binding ≤ 1μM 1,365 35 1 13
Functional ≤ 10μM 1 0 0 0

Reactome Network (3)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 12
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 1
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 4
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 7
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 6
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 3

Collagen degradation

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 3
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 3

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 12
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 1
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 3
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 3
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ELNE_MOUSE Q3UP87 CHEMBL5156 Neutrophil Elastase, Mouse 6 0 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
ELNE-1-E Neutrophil Elastase (cluster #1 Of 3), Eukaryotic 485 35 3 7
ELNE-2-E Neutrophil Elastase (cluster #2 Of 3), Eukaryotic 1,077 3 1 8
ELNE-3-E Neutrophil Elastase (cluster #3 Of 3), Eukaryotic 38 14 0 0
Uniprot Swissprot Chembl Description Number Shared
CEL2A_PIG P08419 CHEMBL2407 Elastase 2A, Pig 25
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 20
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 19
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 18
CTRC_HUMAN Q99895 CHEMBL2386 Chymotrypsin C, Human 16
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 12
CEL2A_HUMAN P08217 CHEMBL2119 Elastase 2A, Human 9
CEL2B_HUMAN P08218 CHEMBL3887 Elastase 2B, Human 9
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 9
CELA1_PIG P00772 CHEMBL3517 Elastase 1, Pig 9
CEL3A_HUMAN P09093 CHEMBL2809 Elastase IIIA, Human 7
CEL3B_HUMAN P08861 CHEMBL4995 Elastase IIIB, Human 7
CEL_BOVIN P30122 CHEMBL2988 Cholesterol Esterase, Bovin 7
CTRB1_HUMAN P17538 CHEMBL4796 Beta-chymotrypsin, Human 7
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 7
KLKB1_HUMAN P03952 CHEMBL2000 Plasma Kallikrein, Human 6
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 4
ELNE_MOUSE Q3UP87 CHEMBL5156 Neutrophil Elastase, Mouse 4
PRTN3_MOUSE Q61096 CHEMBL5384 Myeloblastin, Mouse 4
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 3
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 3
CATG_MOUSE P28293 CHEMBL5622 Cathepsin G, Mouse 3
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 3
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 3
CEL2A_RAT P00774 CHEMBL3888 Elastase 2A, Rat 3
TRYB1_HUMAN Q15661 CHEMBL2617 Tryptase Beta-1, Human 3
TRYD_HUMAN Q9BZJ3 CHEMBL2402 Tryptase Delta, Human 3
TRYG1_HUMAN Q9NRR2 CHEMBL4955 Tryptase Gamma, Human 3
A3EZI9_9HEPC A3EZI9 CHEMBL4893 Hepatitis C Virus NS3 Protease/helicase, 9hepc 2
D2K2A8_9HEPC D2K2A8 CHEMBL2364 Hepatitis C Virus NS4A Protein, 9hepc 2
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 2
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 2
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 2
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 1
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 1
FA10_RAT Q63207 CHEMBL3755 Coagulation Factor X, Rat 1
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
PPGB_HUMAN P10619 CHEMBL6115 Lysosomal Protective Protein, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 1

Most Common Rings