UCSF

Cathepsin S, Human (1,468 Compounds)

Swissprot:
CATS_HUMAN
Stitch:
CATS_HUMAN
UniProt:
P25774
ChEMBL:
CHEMBL2954
Reactome:
REACT_150180
REACT_118572
REACT_111168
REACT_121399
REACT_118632
PDB:
1BXF (DOCK)
1GLO (DOCK)
1MS6 (DOCK)
1NPZ (DOCK)
1NQC (DOCK)
2C0Y (DOCK)
2F1G (DOCK)
2FQ9 (DOCK)
2FRA (DOCK)
2FRQ (DOCK)
2FT2 (DOCK)
2FUD (DOCK)
2FYE (DOCK)
2G6D (DOCK)
2G7Y (DOCK)
2H7J (DOCK)
2HH5 (DOCK)
2HHN (DOCK)
2HXZ (DOCK)
2OP3 (DOCK)
2R9M (DOCK)
2R9N (DOCK)
2R9O (DOCK)
3IEJ (DOCK)
3KWN (DOCK)
3MPE (DOCK)
3MPF (DOCK)
3N3G (DOCK)
3N4C (DOCK)
3OVX (DOCK)
CTSS

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,468 15 5 14
Binding ≤ 1μM 1,255 12 5 13
Functional ≤ 10μM 1 0 0 1
Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 267
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 577
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 2
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 714
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 577
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3

Endosomal/Vacuolar pathway

Uniprot Swissprot Chembl Description Number Shared
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 577
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93

MHC class II antigen presentation

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 267
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 25
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 2
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 2
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 12
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 9
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 714
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 577
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
HG2A_HUMAN P04233 CHEMBL4692 HLA-DR Antigens-associated Invariant Chain, Human 44

Trafficking and processing of endosomal TLR

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 267
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 714
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 577
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CATS_MOUSE O70370 CHEMBL4098 Cathepsin S, Mouse 25 1 0 2
CATS_RAT Q02765 CHEMBL1075217 Cathepsin S, Rat 9 0 0 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
CATS-1-E Cathepsin S (cluster #1 Of 2), Eukaryotic 629 0 0 2
CATS-2-E Cathepsin S (cluster #2 Of 2), Eukaryotic 844 15 5 12
Uniprot Swissprot Chembl Description Number Shared
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 714
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 577
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 267
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 93
HG2A_HUMAN P04233 CHEMBL4692 HLA-DR Antigens-associated Invariant Chain, Human 44
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 39
CATL1_BOVIN P25975 CHEMBL2113 Cathepsin L, Bovin 28
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 25
CATS_MOUSE O70370 CHEMBL4098 Cathepsin S, Mouse 24
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 22
CATL1_RAT P07154 CHEMBL2305 Cathepsin L, Rat 21
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 15
CATK_RABIT P43236 CHEMBL3349 Cathepsin K, Rabit 13
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 13
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 12
CATB_MOUSE P10605 CHEMBL5187 Cathepsin B, Mouse 11
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 9
CATK_MOUSE P55097 CHEMBL1075277 Cathepsin K, Mouse 9
CATL1_MOUSE P06797 CHEMBL5291 Cathepsin L1, Mouse 9
CATS_RAT Q02765 CHEMBL1075217 Cathepsin S, Rat 9
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 8
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 4
ADA1A_RABIT O02824 CHEMBL3637 Alpha-1a Adrenergic Receptor, Rabit 4
CARP_YEAST P07267 CHEMBL4451 Saccharopepesin, Yeast 4
CATZ_HUMAN Q9UBR2 CHEMBL4160 Cathepsin Z, Human 4
GLNA_HUMAN P15104 CHEMBL4612 Glutamine Synthetase, Human 4
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 4
Z50212 Z50212 CHEMBL354 Escherichia Coli 4
CATK_RAT O35186 CHEMBL3034 Cathepsin K, Rat 3
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 3
PTN13_HUMAN Q12923 CHEMBL2976 Protein-tyrosine Phosphatase 1E, Human 3
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 3
Q9NBA7_PLAFA Q9NBA7 CHEMBL4510 Cysteine Protease Falcipain-3, Plafa 3
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 3
A3EZI9_9HEPC A3EZI9 CHEMBL4893 Hepatitis C Virus NS3 Protease/helicase, 9hepc 2
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 2
CATD_HUMAN P07339 CHEMBL2581 Cathepsin D, Human 2
CATE_HUMAN P14091 CHEMBL3092 Cathepsin E, Human 2
CATG_HUMAN P08311 CHEMBL4071 Cathepsin G, Human 2
ELNE_MOUSE Q3UP87 CHEMBL5156 Neutrophil Elastase, Mouse 2
PRTN3_MOUSE Q61096 CHEMBL5384 Myeloblastin, Mouse 2
TP4A1_HUMAN Q93096 CHEMBL1075169 Protein Tyrosine Phosphatase Type IVA 1, Human 2
TP4A2_HUMAN Q12974 CHEMBL1075105 Protein Tyrosine Phosphatase Type IVA 2, Human 2
TP4A3_HUMAN O75365 CHEMBL4162 Protein-tyrosine Phosphatase 4A3, Human 2
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 2
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 1
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1
CATG_MOUSE P28293 CHEMBL5622 Cathepsin G, Mouse 1
CATL3_PARTE Q94715 CHEMBL4097 Cathepsin L2, Parte 1
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 1
CTRA_BOVIN P00766 CHEMBL3314 Alpha-chymotrypsin, Bovin 1
D2K2A8_9HEPC D2K2A8 CHEMBL2364 Hepatitis C Virus NS4A Protein, 9hepc 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
LMCPB_LEIME P36400 CHEMBL3821 Cysteine Proteinase B, Leime 1
RENI_HUMAN P00797 CHEMBL286 Renin, Human 1
Z100750 Z100750 CHEMBL612548 Osteoclasts 1