UCSF

Caspase-6, Human (171 Compounds)

Swissprot:
CASP6_HUMAN
Stitch:
CASP6_HUMAN
UniProt:
P55212
ChEMBL:
CHEMBL3308
Reactome:
REACT_107
REACT_13472
REACT_13541
PDB:
1MI9 (DOCK)
2WDP (DOCK)
3K7E (DOCK)
3NKF (DOCK)
3NR2 (DOCK)
3OD5 (DOCK)
3P45 (DOCK)
3P4U (DOCK)
3QNW (DOCK)
CASP6

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 171 7 0 1
Binding ≤ 1μM 87 7 0 1

Reactome Network (3)

Reactome ID Description Species
REACT_107 Apoptotic cleavage of cellular proteins Homo sapiens
REACT_13472 Breakdown of the nuclear lamina Homo sapiens
REACT_13541 Caspase-mediated cleavage of cytoskeletal proteins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 168
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 145
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 98

Caspase-mediated cleavage of cytoskeletal proteins

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 168
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 145
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 98
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 975 16 2 1
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 75 2 1 2
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 987 29 1 5
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 5 0 0 0
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4 0 0 0
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 433 10 0 2
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 444 4 1 2
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11 2 0 0
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4 0 0 0
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 168
CASP7_HUMAN P55210 CHEMBL3468 Caspase-7, Human 145
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 131
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 98
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 10
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 9
CASP1_MOUSE P29452 CHEMBL4800 Caspase-1, Mouse 5
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 5
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 2
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 2
CATL2_HUMAN O60911 CHEMBL3272 Cathepsin L2, Human 2
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 2
CATZ_HUMAN Q9UBR2 CHEMBL4160 Cathepsin Z, Human 2
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 2
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 2
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 2
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 1

Most Common Rings