UCSF

Cathepsin L2, Human (111 Compounds)

Swissprot:
CATL2_HUMAN
Stitch:
CATL2_HUMAN
UniProt:
O60911
ChEMBL:
CHEMBL3272
Reactome:
REACT_118682
REACT_150180
REACT_118572
REACT_111168
REACT_121399
REACT_118632
PDB:
1FH0 (DOCK)
3H6S (DOCK)
3KFQ (DOCK)
CTSL2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 111 8 9 4
Binding ≤ 1μM 65 7 5 3

Reactome Network (6)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150180 Assembly of collagen fibrils and other multimeric structures Homo sapiens
REACT_118572 Degradation of the extracellular matrix Homo sapiens
REACT_111168 Endosomal/Vacuolar pathway Homo sapiens
REACT_121399 MHC class II antigen presentation Homo sapiens
REACT_118632 Trafficking and processing of endosomal TLR Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 93
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1

Assembly of collagen fibrils and other multimeric structures

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 76
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 93

Degradation of the extracellular matrix

Uniprot Swissprot Chembl Description Number Shared
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 1
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 93
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 93
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1

Endosomal/Vacuolar pathway

Uniprot Swissprot Chembl Description Number Shared
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 93

MHC class II antigen presentation

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 76
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 7
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 11
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 3
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 93
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 93

Trafficking and processing of endosomal TLR

Uniprot Swissprot Chembl Description Number Shared
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 76
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 93
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 88
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 93
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 980 26 7 16

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CATK_HUMAN P43235 CHEMBL268 Cathepsin K, Human 93
CATS_HUMAN P25774 CHEMBL2954 Cathepsin S, Human 93
CATL1_HUMAN P07711 CHEMBL3837 Cathepsin L, Human 88
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 76
CATF_HUMAN Q9UBX1 CHEMBL2517 Cathepsin F, Human 11
CATC_HUMAN P53634 CHEMBL2252 Dipeptidyl Peptidase I, Human 7
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 6
CAN2_HUMAN P17655 CHEMBL2382 Calpain 2, Human 4
CATH_HUMAN P09668 CHEMBL2225 Cathepsin H, Human 3
CATZ_HUMAN Q9UBR2 CHEMBL4160 Cathepsin Z, Human 3
CMA1_HUMAN P23946 CHEMBL4068 Chymase, Human 3
PAPA1_CARPA P00784 CHEMBL4779 Papain, Carpa 3
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 3
A3EZI9_9HEPC A3EZI9 CHEMBL4893 Hepatitis C Virus NS3 Protease/helicase, 9hepc 2
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 2
TPA_HUMAN P00750 CHEMBL1873 Tissue-type Plasminogen Activator, Human 2
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 1
CAN1_PIG P35750 CHEMBL4062 Calpain 1, Pig 1
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 1
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1
CATB_BOVIN P07688 CHEMBL2323 Cathepsin B, Bovin 1
CATK_RABIT P43236 CHEMBL3349 Cathepsin K, Rabit 1
CELA1_HUMAN Q9UNI1 CHEMBL3000 Elastase 1, Human 1
CPNS1_PIG P04574 CHEMBL2205 Calpain Small Subunit 1, Pig 1
D2K2A8_9HEPC D2K2A8 CHEMBL2364 Hepatitis C Virus NS4A Protein, 9hepc 1
ELNE_HUMAN P08246 CHEMBL248 Leukocyte Elastase, Human 1
PLMN_BOVIN P06868 CHEMBL2957 Plasminogen, Bovin 1
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
Q95WR6_LEIDO Q95WR6 CHEMBL4751 Cysteine Protease, Leido 1
Q9N6S8_PLAFA Q9N6S8 CHEMBL5800 Falcipain 2, Plafa 1
Q9NAW4_PLAFA Q9NAW4 CHEMBL1697661 Cysteine Protease Falcipain-3, Plafa 1
Q9NBD4_PLAFA Q9NBD4 CHEMBL5801 Cysteine Protease Falcipain-2, Plafa 1
ST14_HUMAN Q9Y5Y6 CHEMBL3018 Matriptase, Human 1
TRY1_BOVIN P00760 CHEMBL3769 Trypsin I, Bovin 1

Most Common Rings