| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 11 | 2 | 0 | 0 |
| Binding ≤ 1μM | 10 | 2 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_607 | Activation of caspases through apoptosome-mediated cleavage | Homo sapiens |
| REACT_12564 | AKT phosphorylates targets in the cytosol | Homo sapiens |
| REACT_147727 | Constitutive PI3K/AKT Signaling in Cancer | Homo sapiens |
| REACT_89 | Formation of apoptosome | Homo sapiens |
| REACT_75776 | NOD1/2 Signaling Pathway | Homo sapiens |
| REACT_22128 | Role of DCC in regulating apoptosis | Homo sapiens |
| REACT_2190 | SMAC binds to IAPs | Homo sapiens |
| REACT_1767 | SMAC-mediated dissociation of IAP:caspase complexes | Homo sapiens |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| CASP3_HUMAN | P42574 | CHEMBL2334 | Caspase-3, Human | 11 |
| CASP7_HUMAN | P55210 | CHEMBL3468 | Caspase-7, Human | 8 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| CASP1_HUMAN | P29466 | CHEMBL4801 | Caspase-1, Human | 8 |
| CASP8_HUMAN | Q14790 | CHEMBL3776 | Caspase-8, Human | 11 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| CASP3_HUMAN | P42574 | CHEMBL2334 | Caspase-3, Human | 11 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| CASP3_HUMAN | P42574 | CHEMBL2334 | Caspase-3, Human | 11 |
| CASP7_HUMAN | P55210 | CHEMBL3468 | Caspase-7, Human | 8 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| CASP3_HUMAN | P42574 | CHEMBL2334 | Caspase-3, Human | 11 |
| CASP7_HUMAN | P55210 | CHEMBL3468 | Caspase-7, Human | 8 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| CASP1_HUMAN | P29466 | CHEMBL4801 | Caspase-1, Human | 975 | 16 | 2 | 1 |
| CASP2_HUMAN | P42575 | CHEMBL4884 | Caspase-2, Human | 75 | 2 | 1 | 2 |
| CASP3_HUMAN | P42574 | CHEMBL2334 | Caspase-3, Human | 987 | 29 | 1 | 5 |
| CASP4_HUMAN | P49662 | CHEMBL2226 | Caspase-4, Human | 5 | 0 | 0 | 0 |
| CASP5_HUMAN | P51878 | CHEMBL3131 | Caspase-5, Human | 4 | 0 | 0 | 0 |
| CASP6_HUMAN | P55212 | CHEMBL3308 | Caspase-6, Human | 171 | 7 | 0 | 1 |
| CASP7_HUMAN | P55210 | CHEMBL3468 | Caspase-7, Human | 433 | 10 | 0 | 2 |
| CASP8_HUMAN | Q14790 | CHEMBL3776 | Caspase-8, Human | 444 | 4 | 1 | 2 |
| CASPA_HUMAN | Q92851 | CHEMBL5037 | Caspase-10, Human | 4 | 0 | 0 | 0 |
| CASPE_HUMAN | P31944 | CHEMBL5991 | Caspase-14, Human | 1 | 0 | 0 | 0 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| CASP3_HUMAN | P42574 | CHEMBL2334 | Caspase-3, Human | 11 |
| CASP8_HUMAN | Q14790 | CHEMBL3776 | Caspase-8, Human | 11 |
| CASP6_HUMAN | P55212 | CHEMBL3308 | Caspase-6, Human | 9 |
| CASP1_HUMAN | P29466 | CHEMBL4801 | Caspase-1, Human | 8 |
| CASP7_HUMAN | P55210 | CHEMBL3468 | Caspase-7, Human | 8 |
| CASP1_MOUSE | P29452 | CHEMBL4800 | Caspase-1, Mouse | 7 |
| CAN1_HUMAN | P07384 | CHEMBL3891 | Calpain 1, Human | 2 |
| CATB_HUMAN | P07858 | CHEMBL4072 | Cathepsin B, Human | 2 |
| CATB_RAT | P00787 | CHEMBL2602 | Cathepsin B, Rat | 2 |