UCSF

Caspase-7, Human (433 Compounds)

Swissprot:
CASP7_HUMAN
Stitch:
CASP7_HUMAN
UniProt:
P55210
ChEMBL:
CHEMBL3468
Reactome:
REACT_607
REACT_107
REACT_13541
REACT_2190
REACT_1767
PDB:
1F1J (DOCK)
1GQF (DOCK)
1I4O (DOCK)
1I51 (DOCK)
1K86 (DOCK)
1K88 (DOCK)
1KMC (DOCK)
1MIA (DOCK)
1SHJ (DOCK)
1SHL (DOCK)
2QL5 (DOCK)
2QL7 (DOCK)
2QL9 (DOCK)
2QLB (DOCK)
2QLF (DOCK)
2QLJ (DOCK)
3EDR (DOCK)
3H1P (DOCK)
3IBC (DOCK)
3IBF (DOCK)
3R5K (DOCK)
CASP7

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 433 10 0 2
Binding ≤ 1μM 287 5 0 2

Reactome Network (5)

Reactome ID Description Species
REACT_607 Activation of caspases through apoptosome-mediated cleavage Homo sapiens
REACT_107 Apoptotic cleavage of cellular proteins Homo sapiens
REACT_13541 Caspase-mediated cleavage of cytoskeletal proteins Homo sapiens
REACT_2190 SMAC binds to IAPs Homo sapiens
REACT_1767 SMAC-mediated dissociation of IAP:caspase complexes Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 433
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 8

Apoptotic cleavage of cellular proteins

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 433
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 145
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 218

Caspase-mediated cleavage of cytoskeletal proteins

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 433
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 145
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 218

SMAC binds to IAPs

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 433
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 8

SMAC-mediated dissociation of IAP:caspase complexes

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 433
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 8
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 975 16 2 1
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 75 2 1 2
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 987 29 1 5
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 5 0 0 0
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4 0 0 0
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 171 7 0 1
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 444 4 1 2
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 11 2 0 0
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4 0 0 0
CASPE_HUMAN P31944 CHEMBL5991 Caspase-14, Human 1 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CASP3_HUMAN P42574 CHEMBL2334 Caspase-3, Human 433
CASP1_HUMAN P29466 CHEMBL4801 Caspase-1, Human 279
CASP8_HUMAN Q14790 CHEMBL3776 Caspase-8, Human 218
CASP6_HUMAN P55212 CHEMBL3308 Caspase-6, Human 145
CASP2_HUMAN P42575 CHEMBL4884 Caspase-2, Human 10
CASP9_HUMAN P55211 CHEMBL2273 Caspase-9, Human 8
CASP1_MOUSE P29452 CHEMBL4800 Caspase-1, Mouse 4
CASP4_HUMAN P49662 CHEMBL2226 Caspase-4, Human 4
CASP5_HUMAN P51878 CHEMBL3131 Caspase-5, Human 4
CASPA_HUMAN Q92851 CHEMBL5037 Caspase-10, Human 4
CAN1_HUMAN P07384 CHEMBL3891 Calpain 1, Human 2
CATB_HUMAN P07858 CHEMBL4072 Cathepsin B, Human 2
CATB_RAT P00787 CHEMBL2602 Cathepsin B, Rat 2

Most Common Rings