UCSF

Integrin Beta-3, Human (1,479 Compounds)

Swissprot:
ITB3_HUMAN
Stitch:
ITB3_HUMAN
UniProt:
P05106
ChEMBL:
CHEMBL207
Reactome:
REACT_163906
REACT_150366
REACT_15443
REACT_15523
REACT_13552
REACT_150331
REACT_15381
REACT_12519
REACT_318
REACT_22272
REACT_163942
REACT_228166
PDB:
1JV2 (DOCK)
1KUP (DOCK)
1KUZ (DOCK)
1L5G (DOCK)
1M1X (DOCK)
1M8O (DOCK)
1MK7 (DOCK)
1MK9 (DOCK)
1RN0 (DOCK)
1S4X (DOCK)
1TYE (DOCK)
1U8C (DOCK)
2INI (DOCK)
2K9J (DOCK)
2KNC (DOCK)
2KV9 (DOCK)
2L1C (DOCK)
2L91 (DOCK)
2LJD (DOCK)
2LJE (DOCK)
2LJF (DOCK)
2Q6W (DOCK)
2RMZ (DOCK)
2RN0 (DOCK)
2VC2 (DOCK)
2VDK (DOCK)
2VDL (DOCK)
2VDM (DOCK)
2VDN (DOCK)
2VDO (DOCK)
2VDP (DOCK)
2VDQ (DOCK)
2VDR (DOCK)
3FCS (DOCK)
3FCU (DOCK)
3IJE (DOCK)
3NID (DOCK)
3NIF (DOCK)
3NIG (DOCK)
ITGB3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,479 4 8 8
Binding ≤ 1μM 1,221 4 8 8
Functional ≤ 10μM 838 5 7 8

Reactome Network (12)

Reactome ID Description Species
REACT_163906 ECM proteoglycans Homo sapiens
REACT_150366 Elastic fibre formation Homo sapiens
REACT_15443 GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens
REACT_15523 Integrin alphaIIb beta3 signaling Homo sapiens
REACT_13552 Integrin cell surface interactions Homo sapiens
REACT_150331 Molecules associated with elastic fibres Homo sapiens
REACT_15381 p130Cas linkage to MAPK signaling for integrins Homo sapiens
REACT_12519 PECAM1 interactions Homo sapiens
REACT_318 Platelet degranulation Homo sapiens
REACT_22272 Signal transduction by L1 Homo sapiens
REACT_163942 Syndecan interactions Homo sapiens
REACT_228166 VEGFA-VEGFR2 Pathway Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 27
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 157
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83

Elastic fibre formation

Uniprot Swissprot Chembl Description Number Shared
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 27
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 73
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83

GRB2:SOS provides linkage to MAPK signaling for Integrins

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870

Integrin alphaIIb beta3 signaling

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870

Integrin cell surface interactions

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 27
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 47
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 27
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 157
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83

Molecules associated with elastic fibres

Uniprot Swissprot Chembl Description Number Shared
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 157
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83

p130Cas linkage to MAPK signaling for integrins

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870

PECAM1 interactions

Uniprot Swissprot Chembl Description Number Shared
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179

Platelet degranulation

Uniprot Swissprot Chembl Description Number Shared
ALBU_HUMAN P02768 CHEMBL3253 Serum Albumin, Human 2
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870

Signal transduction by L1

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 27
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 73

Syndecan interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 27
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 73
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 157

VEGFA-VEGFR2 Pathway

Uniprot Swissprot Chembl Description Number Shared
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 249 1 0 0
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 207 5 0 0
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 280 0 0 1
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 213 0 0 0
ITB7_HUMAN P26010 CHEMBL2979 Integrin Beta-7, Human 355 9 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1870
Z104292 Z104292 CHEMBL1907598 Integrin Alpha-V/beta-3 459
Z50587 Z50587 CHEMBL372 Homo Sapiens 340
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 179
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 157
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 64
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 47
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 27
Z50512 Z50512 CHEMBL369 Cavia Porcellus 27
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 19
Z50588 Z50588 CHEMBL373 Canis Familiaris 8
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 7
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 7
Z102352 Z102352 CHEMBL613652 Plasma 6
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 5
PAR4_HUMAN Q96RI0 CHEMBL4691 Proteinase Activated Receptor 4, Human 5
ALBU_HUMAN P02768 CHEMBL3253 Serum Albumin, Human 2
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 1
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
O77669_CANFA O77669 CHEMBL3929 Coagulation Factor X, Canine 1

Most Common Rings