UCSF

Integrin Alpha-IIb, Human (1,479 Compounds)

Swissprot:
ITA2B_HUMAN
Stitch:
ITA2B_HUMAN
UniProt:
P08514
ChEMBL:
CHEMBL212
Reactome:
REACT_163906
REACT_15443
REACT_15523
REACT_13552
REACT_15381
REACT_318
REACT_22272
PDB:
1DPK (DOCK)
1DPQ (DOCK)
1JX5 (DOCK)
1KUP (DOCK)
1KUZ (DOCK)
1M8O (DOCK)
1RN0 (DOCK)
1S4W (DOCK)
1TYE (DOCK)
1UV9 (DOCK)
2K1A (DOCK)
2K9J (DOCK)
2KNC (DOCK)
2VC2 (DOCK)
2VDK (DOCK)
2VDL (DOCK)
2VDM (DOCK)
2VDN (DOCK)
2VDO (DOCK)
2VDP (DOCK)
2VDQ (DOCK)
2VDR (DOCK)
3FCS (DOCK)
3FCU (DOCK)
3NID (DOCK)
3NIF (DOCK)
3NIG (DOCK)
ITGA2B

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,479 4 8 8
Binding ≤ 1μM 1,220 4 8 8
Functional ≤ 10μM 793 5 7 8

Reactome Network (7)

Reactome ID Description Species
REACT_163906 ECM proteoglycans Homo sapiens
REACT_15443 GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens
REACT_15523 Integrin alphaIIb beta3 signaling Homo sapiens
REACT_13552 Integrin cell surface interactions Homo sapiens
REACT_15381 p130Cas linkage to MAPK signaling for integrins Homo sapiens
REACT_318 Platelet degranulation Homo sapiens
REACT_22272 Signal transduction by L1 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 1
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 182
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 72
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 163
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83

GRB2:SOS provides linkage to MAPK signaling for Integrins

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870

Integrin alphaIIb beta3 signaling

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870

Integrin cell surface interactions

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 1
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 2
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 26
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 182
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 72
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 163
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83

p130Cas linkage to MAPK signaling for integrins

Uniprot Swissprot Chembl Description Number Shared
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870

Platelet degranulation

Uniprot Swissprot Chembl Description Number Shared
ALBU_HUMAN P02768 CHEMBL3253 Serum Albumin, Human 2
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870

Signal transduction by L1

Uniprot Swissprot Chembl Description Number Shared
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 26
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 182
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 72
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 1870
Z104292 Z104292 CHEMBL1907598 Integrin Alpha-V/beta-3 465
Z50587 Z50587 CHEMBL372 Homo Sapiens 340
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 182
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 163
ITB6_HUMAN P18564 CHEMBL4876 Integrin Beta-6, Human 83
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 63
Z50512 Z50512 CHEMBL369 Cavia Porcellus 27
ITA5_HUMAN P08648 CHEMBL3955 Fibronectin Receptor Alpha, Human 18
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 15
Z50588 Z50588 CHEMBL373 Canis Familiaris 8
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 7
UROK_HUMAN P00749 CHEMBL3286 Urokinase-type Plasminogen Activator, Human 7
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 5
PAR4_HUMAN Q96RI0 CHEMBL4691 Proteinase Activated Receptor 4, Human 5
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 4
ALBU_HUMAN P02768 CHEMBL3253 Serum Albumin, Human 2
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 2
FIBB_HUMAN P02675 CHEMBL2048 Fibrinogen Beta Chain, Human 1
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 1
O77669_CANFA O77669 CHEMBL3929 Coagulation Factor X, Canine 1

Most Common Rings