UCSF

Fibronectin Receptor Alpha, Human (67 Compounds)

Swissprot:
ITA5_HUMAN
Stitch:
ITA5_HUMAN
UniProt:
P08648
ChEMBL:
CHEMBL3955
Reactome:
REACT_12051
REACT_150366
REACT_160131
REACT_13552
REACT_22272
PDB:
ITGA5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 67 2 0 1
Binding ≤ 1μM 55 1 0 1
Functional ≤ 10μM 31 2 2 2

Reactome Network (5)

Reactome ID Description Species
REACT_12051 Cell surface interactions at the vascular wall Homo sapiens
REACT_150366 Elastic fibre formation Homo sapiens
REACT_160131 Fibronectin matrix formation Homo sapiens
REACT_13552 Integrin cell surface interactions Homo sapiens
REACT_22272 Signal transduction by L1 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 61

Elastic fibre formation

Uniprot Swissprot Chembl Description Number Shared
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 48
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 61
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27

Fibronectin matrix formation

Uniprot Swissprot Chembl Description Number Shared
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 61

Integrin cell surface interactions

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 26
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 48
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 61
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 31

Signal transduction by L1

Uniprot Swissprot Chembl Description Number Shared
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 26
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 48
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 61
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 27
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 1,479 4 8 8
ITA2_HUMAN P17301 CHEMBL4998 Integrin Alpha-2, Human 32 0 0 0
ITA3_HUMAN P26006 CHEMBL3525 Integrin Alpha-3, Human 0 0 0 0
ITA4_HUMAN P13612 CHEMBL278 Integrin Alpha-4, Human 769 9 0 0
ITAL_HUMAN P20701 CHEMBL1803 Leukocyte Adhesion Glycoprotein LFA-1 Alpha, Human 471 24 2 1
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 434 0 0 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ITA5-1-E Fibronectin Receptor Alpha (cluster #1 Of 2), Eukaryotic 50 0 0 0
ITA5-2-E Fibronectin Receptor Alpha (cluster #2 Of 2), Eukaryotic 17 2 0 1
Uniprot Swissprot Chembl Description Number Shared
ITB1_HUMAN P05556 CHEMBL1905 Fibronectin Receptor Beta, Human 61
Z104292 Z104292 CHEMBL1907598 Integrin Alpha-V/beta-3 58
ITAV_HUMAN P06756 CHEMBL3660 Vitronectin Receptor Alpha, Human 48
ITB5_HUMAN P18084 CHEMBL2600 Integrin Beta-5, Human 31
ITB3_HUMAN P05106 CHEMBL207 Integrin Beta-3, Human 19
ITA2B_HUMAN P08514 CHEMBL212 Integrin Alpha-IIb, Human 18
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 13
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 13
ACHB4_HUMAN P30926 CHEMBL3002 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human 13
Z104282 Z104282 CHEMBL1907588 Acetylcholine Receptor; Alpha1/beta1/delta/gamma 7
Z104285 Z104285 CHEMBL1907591 Neuronal Acetylcholine Receptor; Alpha4/beta4 6
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 3
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 1