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ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (434)
Reactome (10)
Related By:
Pathway (16)
Organism (0)
Gene (0)
Org. Clust. (0)
ChEMBL (11)
Rings (14)

Vitronectin Receptor Alpha, Human (434 Compounds)

Swissprot:: ITAV_HUMAN
Stitch:: ITAV_HUMAN
UniProt:: P06756
ChEMBL:: CHEMBL3660
Reactome:: REACT_111174; REACT_163906; REACT_150366; REACT_13552; REACT_169262; REACT_150331; REACT_12519; REACT_22272; REACT_163942; REACT_228166
PDB:: 1JV2 (DOCK); 1L5G (DOCK); 1M1X (DOCK); 1U8C (DOCK); 3IJE (DOCK); ITGAV

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	434	0	0	1
Binding ≤ 1μM	358	0	0	1
Functional ≤ 10μM	53	0	0	0

Reactome ID	Description	Species
REACT_111174	Cross-presentation of particulate exogenous antigens (phagosomes)	Homo sapiens
REACT_163906	ECM proteoglycans	Homo sapiens
REACT_150366	Elastic fibre formation	Homo sapiens
REACT_13552	Integrin cell surface interactions	Homo sapiens
REACT_169262	Laminin interactions	Homo sapiens
REACT_150331	Molecules associated with elastic fibres	Homo sapiens
REACT_12519	PECAM1 interactions	Homo sapiens
REACT_22272	Signal transduction by L1	Homo sapiens
REACT_163942	Syndecan interactions	Homo sapiens
REACT_228166	VEGFA-VEGFR2 Pathway	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	258

ECM proteoglycans

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	182
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	1
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	258
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	213

Elastic fibre formation

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	48
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	213

Integrin cell surface interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
FIBB_HUMAN	P02675	CHEMBL2048	Fibrinogen Beta Chain, Human	1
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	182
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	1
ITA4_HUMAN	P13612	CHEMBL278	Integrin Alpha-4, Human	1
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	48
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	258
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	213
ITB7_HUMAN	P26010	CHEMBL2979	Integrin Beta-7, Human	1

Laminin interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	1
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101

Molecules associated with elastic fibres

Uniprot	Swissprot	Chembl	Description	Number Shared
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	258
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	213

PECAM1 interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179

Signal transduction by L1

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	182
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	48
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179

Syndecan interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	1
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	258

VEGFA-VEGFR2 Pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
Z104292	Z104292	CHEMBL1907598	Integrin Alpha-V/beta-3	381
ITB5_HUMAN	P18084	CHEMBL2600	Integrin Beta-5, Human	258
ITB6_HUMAN	P18564	CHEMBL4876	Integrin Beta-6, Human	213
ITA2B_HUMAN	P08514	CHEMBL212	Integrin Alpha-IIb, Human	182
ITB3_HUMAN	P05106	CHEMBL207	Integrin Beta-3, Human	179
ITB1_HUMAN	P05556	CHEMBL1905	Fibronectin Receptor Beta, Human	101
ITA5_HUMAN	P08648	CHEMBL3955	Fibronectin Receptor Alpha, Human	48
FIBB_HUMAN	P02675	CHEMBL2048	Fibrinogen Beta Chain, Human	1
ITA2_HUMAN	P17301	CHEMBL4998	Integrin Alpha-2, Human	1
ITA4_HUMAN	P13612	CHEMBL278	Integrin Alpha-4, Human	1
ITB7_HUMAN	P26010	CHEMBL2979	Integrin Beta-7, Human	1

Synonyms
Compounds (434)
Related By:
Pathway (16)
Organism (0)
Gene (0)
ChEMBL (11)
Org. Clust. (0)
Rings (14)