UCSF

Cell Division Cycle 7-related Protein Kinase, Human (223 Compounds)

Swissprot:
CDC7_HUMAN
Stitch:
CDC7_HUMAN
UniProt:
O00311
ChEMBL:
CHEMBL5443
Reactome:
REACT_6769
REACT_1095
PDB:
CDC7

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 223 5 0 1
Binding ≤ 1μM 215 4 0 1

Reactome Network (2)

Reactome ID Description Species
REACT_6769 Activation of ATR in response to replication stress Homo sapiens
REACT_1095 Activation of the pre-replicative complex Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 4
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 1

Activation of the pre-replicative complex

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CDC42_HUMAN P60953 CHEMBL6088 Cell Division Control Protein 42 Homolog, Human 10 0 1 0
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 15
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 6
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 4
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 3
MAPK2_HUMAN P49137 CHEMBL2208 MAP Kinase-activated Protein Kinase 2, Human 3
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 2
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 2
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 2
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 2
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 2
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 1
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 1
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 1
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 1
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 1
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 1
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 1
CHK2_HUMAN O96017 CHEMBL2527 Serine/threonine-protein Kinase Chk2, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
INSR_HUMAN P06213 CHEMBL1981 Insulin Receptor, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 1
KS6A5_HUMAN O75582 CHEMBL4237 Ribosomal Protein S6 Kinase Alpha 5, Human 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
MAPK5_HUMAN Q8IW41 CHEMBL3094 MAP Kinase-activated Protein Kinase 5, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 1
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP Kinase Signal-integrating Kinase 2, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 1
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
TAOK1_HUMAN Q7L7X3 CHEMBL5261 Serine/threonine-protein Kinase TAO1, Human 1
TAOK3_HUMAN Q9H2K8 CHEMBL5701 Serine/threonine-protein Kinase TAO3, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1

Most Common Rings