UCSF

Cyclin-T2, Human (2 Compounds)

Swissprot:
CCNT2_HUMAN
Stitch:
CCNT2_HUMAN
UniProt:
O60583
ChEMBL:
CHEMBL1293321
Reactome:
REACT_22201
REACT_1845
REACT_6259
REACT_6244
REACT_22107
REACT_833
REACT_120734
PDB:
2IVX (DOCK)
CCNT2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2 1 0 1
Binding ≤ 1μM 2 1 0 1

Reactome Network (7)

Reactome ID Description Species
REACT_22201 Formation of HIV elongation complex in the absence of HIV Tat Homo sapiens
REACT_1845 Formation of RNA Pol II elongation complex Homo sapiens
REACT_6259 HIV elongation arrest and recovery Homo sapiens
REACT_6244 Pausing and recovery of HIV elongation Homo sapiens
REACT_22107 RNA Polymerase II Pre-transcription Events Homo sapiens
REACT_833 RNA Polymerase II Transcription Elongation Homo sapiens
REACT_120734 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 1
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 1

Formation of RNA Pol II elongation complex

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 1
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 1

HIV elongation arrest and recovery

Uniprot Swissprot Chembl Description Number Shared
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2

Pausing and recovery of HIV elongation

Uniprot Swissprot Chembl Description Number Shared
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2

RNA Polymerase II Pre-transcription Events

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 1
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 1

RNA Polymerase II Transcription Elongation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 1
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 1

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Uniprot Swissprot Chembl Description Number Shared
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 30 5 2 5

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 2
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 2
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 2
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 2
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 2
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 2
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 2
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 2
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 2
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 2
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 1
CDC7_HUMAN O00311 CHEMBL5443 Cell Division Cycle 7-related Protein Kinase, Human 1
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 1
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 1
DYR1A_MOUSE Q61214 CHEMBL4750 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Mouse 1
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KC1G1_HUMAN Q9HCP0 CHEMBL2426 Casein Kinase I Gamma 1, Human 1
KC1G2_HUMAN P78368 CHEMBL2543 Casein Kinase I Gamma 2, Human 1
KC1G3_HUMAN Q9Y6M4 CHEMBL5084 Casein Kinase I Isoform Gamma-3, Human 1
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
MAT1_HUMAN P51948 CHEMBL5053 CDK-activating Kinase Assembly Factor MAT1, Human 1
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 1
TAOK1_HUMAN Q7L7X3 CHEMBL5261 Serine/threonine-protein Kinase TAO1, Human 1
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 1
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 1
Z104296 Z104296 CHEMBL1907602 Cyclin-dependent Kinase 1/cyclin B1 1
Z104299 Z104299 CHEMBL1907605 Cyclin-dependent Kinase 2/cyclin E1 1