UCSF

CDK-activating Kinase Assembly Factor MAT1, Human (10 Compounds)

Swissprot:
MAT1_HUMAN
Stitch:
MAT1_HUMAN
UniProt:
P51948
ChEMBL:
CHEMBL5053
Reactome:
REACT_1857
REACT_9029
REACT_821
REACT_1574
REACT_311
REACT_2222
REACT_22201
REACT_6346
REACT_257
REACT_1845
REACT_846
REACT_6319
REACT_1941
REACT_6332
REACT_1470
REACT_200856
REACT_975
REACT_6237
REACT_2204
REACT_1913
REACT_953
REACT_1074
REACT_6253
REACT_22107
REACT_2089
REACT_833
REACT_1851
REACT_834
REACT_1655
REACT_6162
REACT_6233
PDB:
1G25 (DOCK)
MNAT1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 10 4 0 1
Binding ≤ 1μM 10 4 0 1

Reactome Network (31)

Reactome ID Description Species
REACT_1857 Cyclin A/B1 associated events during G2/M transition Homo sapiens
REACT_9029 Cyclin A:Cdk2-associated events at S phase entry Homo sapiens
REACT_821 Cyclin D associated events in G1 Homo sapiens
REACT_1574 Cyclin E associated events during G1/S transition Homo sapiens
REACT_311 Dual incision reaction in GG-NER Homo sapiens
REACT_2222 Dual incision reaction in TC-NER Homo sapiens
REACT_22201 Formation of HIV elongation complex in the absence of HIV Tat Homo sapiens
REACT_6346 Formation of HIV-1 elongation complex containing HIV-1 Tat Homo sapiens
REACT_257 Formation of incision complex in GG-NER Homo sapiens
REACT_1845 Formation of RNA Pol II elongation complex Homo sapiens
REACT_846 Formation of the Early Elongation Complex Homo sapiens
REACT_6319 Formation of the HIV-1 Early Elongation Complex Homo sapiens
REACT_1941 Formation of transcription-coupled NER (TC-NER) repair complex Homo sapiens
REACT_6332 HIV Transcription Initiation Homo sapiens
REACT_1470 mRNA Capping Homo sapiens
REACT_200856 NoRC negatively regulates rRNA expression Homo sapiens
REACT_975 RNA Pol II CTD phosphorylation and interaction with CE Homo sapiens
REACT_6237 RNA Pol II CTD phosphorylation and interaction with CE Homo sapiens
REACT_2204 RNA Polymerase I Chain Elongation Homo sapiens
REACT_1913 RNA Polymerase I Promoter Escape Homo sapiens
REACT_953 RNA Polymerase I Transcription Initiation Homo sapiens
REACT_1074 RNA Polymerase I Transcription Termination Homo sapiens
REACT_6253 RNA Polymerase II HIV Promoter Escape Homo sapiens
REACT_22107 RNA Polymerase II Pre-transcription Events Homo sapiens
REACT_2089 RNA Polymerase II Promoter Escape Homo sapiens
REACT_833 RNA Polymerase II Transcription Elongation Homo sapiens
REACT_1851 RNA Polymerase II Transcription Initiation Homo sapiens
REACT_834 RNA Polymerase II Transcription Initiation And Promoter Clearance Homo sapiens
REACT_1655 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Homo sapiens
REACT_6162 Tat-mediated elongation of the HIV-1 transcript Homo sapiens
REACT_6233 Transcription of the HIV genome Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 1
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Cyclin A:Cdk2-associated events at S phase entry

Uniprot Swissprot Chembl Description Number Shared
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 1
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Cyclin D associated events in G1

Uniprot Swissprot Chembl Description Number Shared
CCND3_HUMAN P30281 CHEMBL2422 G1/S-specific Cyclin D3, Human 1
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Cyclin E associated events during G1/S transition

Uniprot Swissprot Chembl Description Number Shared
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 1
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 1
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 2
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Dual incision reaction in GG-NER

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Dual incision reaction in TC-NER

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Formation of HIV elongation complex in the absence of HIV Tat

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4

Formation of HIV-1 elongation complex containing HIV-1 Tat

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4

Formation of incision complex in GG-NER

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Formation of RNA Pol II elongation complex

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4

Formation of the Early Elongation Complex

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Formation of the HIV-1 Early Elongation Complex

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Formation of transcription-coupled NER (TC-NER) repair complex

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

HIV Transcription Initiation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

mRNA Capping

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

NoRC negatively regulates rRNA expression

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Pol II CTD phosphorylation and interaction with CE

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10

RNA Pol II CTD phosphorylation and interaction with CE

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10

RNA Pol II CTD phosphorylation and interaction with CE

Uniprot Swissprot Chembl Description Number Shared
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Pol II CTD phosphorylation and interaction with CE

Uniprot Swissprot Chembl Description Number Shared
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase I Chain Elongation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase I Promoter Escape

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase I Transcription Initiation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase I Transcription Termination

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase II HIV Promoter Escape

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase II Pre-transcription Events

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4

RNA Polymerase II Promoter Escape

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase II Transcription Elongation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4

RNA Polymerase II Transcription Initiation

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase II Transcription Initiation And Promoter Clearance

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10

Tat-mediated elongation of the HIV-1 transcript

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4

Transcription of the HIV genome

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MATK_HUMAN P42679 CHEMBL4175 Tyrosine-protein Kinase CTK, Human 0 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CCNH_HUMAN P51946 CHEMBL2165 Cyclin H, Human 10
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 10
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 4
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 4
Z104296 Z104296 CHEMBL1907602 Cyclin-dependent Kinase 1/cyclin B1 4
CCNT1_HUMAN O60563 CHEMBL2108 Cyclin T1, Human 3
Z104299 Z104299 CHEMBL1907605 Cyclin-dependent Kinase 2/cyclin E1 3
CCNA2_HUMAN P20248 CHEMBL2582 Cyclin A2, Human 2
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 2
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 2
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 2
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 2
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
CCNA1_HUMAN P78396 CHEMBL3609 Cyclin A1, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CCND3_HUMAN P30281 CHEMBL2422 G1/S-specific Cyclin D3, Human 1
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 1
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 1
CCNT2_HUMAN O60583 CHEMBL1293321 Cyclin-T2, Human 1
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
DYR1A_MOUSE Q61214 CHEMBL4750 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Mouse 1
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
INSRR_HUMAN P14616 CHEMBL5483 Insulin Receptor-related Protein, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KC1G1_HUMAN Q9HCP0 CHEMBL2426 Casein Kinase I Gamma 1, Human 1
KC1G2_HUMAN P78368 CHEMBL2543 Casein Kinase I Gamma 2, Human 1
KC1G3_HUMAN Q9Y6M4 CHEMBL5084 Casein Kinase I Isoform Gamma-3, Human 1
KKCC2_HUMAN Q96RR4 CHEMBL5284 CaM-kinase Kinase Beta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 1
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated Protein Kinase 15, Human 1
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 1
TTK_HUMAN P33981 CHEMBL3983 Dual Specificity Protein Kinase TTK, Human 1

Most Common Rings