ZINC 12

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Names
Compounds (1,512)
Reactome (4)
Related By:
Pathway (2)
Organism (2)
Gene (7)
Org. Clust. (3)
ChEMBL (66)
Rings (23)

Protein-tyrosine Phosphatase 1B, Human (1,512 Compounds)

Swissprot:: PTN1_HUMAN
Stitch:: PTN1_HUMAN
UniProt:: P18031
ChEMBL:: CHEMBL335
Reactome:: REACT_111133; REACT_15523; REACT_25216; REACT_24980
PDB:: 1A5Y (DOCK); 1AAX (DOCK); 1BZC (DOCK); 1BZH (DOCK); 1BZJ (DOCK); 1C83 (DOCK); 1C84 (DOCK); 1C85 (DOCK); 1C86 (DOCK); 1C87 (DOCK); 1C88 (DOCK); 1ECV (DOCK); 1EEN (DOCK); 1EEO (DOCK); 1G1F (DOCK); 1G1G (DOCK); 1G1H (DOCK); 1G7F (DOCK); 1G7G (DOCK); 1GFY (DOCK); 1I57 (DOCK); 1JF7 (DOCK); 1KAK (DOCK); 1KAV (DOCK); 1L8G (DOCK); 1LQF (DOCK); 1NL9 (DOCK); 1NNY (DOCK); 1NO6 (DOCK); 1NWE (DOCK); 1NWL (DOCK); 1NZ7 (DOCK); 1OEM (DOCK); 1OEO (DOCK); 1OES (DOCK); 1OET (DOCK); 1OEU (DOCK); 1OEV (DOCK); 1ONY (DOCK); 1ONZ (DOCK); 1PA1 (DOCK); 1PH0 (DOCK); 1PTT (DOCK); 1PTU (DOCK); 1PTV (DOCK); 1PTY (DOCK); 1PXH (DOCK); 1PYN (DOCK); 1Q1M (DOCK); 1Q6J (DOCK); 1Q6M (DOCK); 1Q6N (DOCK); 1Q6P (DOCK); 1Q6S (DOCK); 1Q6T (DOCK); 1QXK (DOCK); 1SUG (DOCK); 1T48 (DOCK); 1T49 (DOCK); 1T4J (DOCK); 1WAX (DOCK); 1XBO (DOCK); 2AZR (DOCK); 2B07 (DOCK); 2B4S (DOCK); 2BGD (DOCK); 2BGE (DOCK); 2CM2 (DOCK); 2CM3 (DOCK); 2CM7 (DOCK); 2CM8 (DOCK); 2CMA (DOCK); 2CMB (DOCK); 2CMC (DOCK); 2CNE (DOCK); 2CNF (DOCK); 2CNG (DOCK); 2CNH (DOCK); 2CNI (DOCK); 2F6F (DOCK); 2F6T (DOCK); 2F6V (DOCK); 2F6W (DOCK); 2F6Y (DOCK); 2F6Z (DOCK); 2F70 (DOCK); 2F71 (DOCK); 2FJM (DOCK); 2FJN (DOCK); 2H4G (DOCK); 2H4K (DOCK); 2HB1 (DOCK); 2HNP (DOCK); 2HNQ (DOCK); 2NT7 (DOCK); 2NTA (DOCK); 2QBP (DOCK); 2QBQ (DOCK); 2QBR (DOCK); 2QBS (DOCK); 2VEU (DOCK); 2VEV (DOCK); 2VEW (DOCK); 2VEX (DOCK); 2VEY (DOCK); 2ZMM (DOCK); 2ZN7 (DOCK); 3A5J (DOCK); 3A5K (DOCK); 3CWE (DOCK); 3D9C (DOCK); 3EAX (DOCK); 3EB1 (DOCK); 3EU0 (DOCK); 3I7Z (DOCK); 3I80 (DOCK); 3SME (DOCK); 3ZV2 (DOCK); PTPN1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,512	31	25	26
Binding ≤ 1μM	862	6	1	9

Reactome ID	Description	Species
REACT_111133	Growth hormone receptor signaling	Homo sapiens
REACT_15523	Integrin alphaIIb beta3 signaling	Homo sapiens
REACT_25216	Regulation of IFNA signaling	Homo sapiens
REACT_24980	Regulation of IFNG signaling	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PTN6_HUMAN	P29350	CHEMBL3166	Protein-tyrosine Phosphatase 1C, Human	26

Regulation of IFNA signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
PTN11_HUMAN	Q06124	CHEMBL3864	Protein-tyrosine Phosphatase 2C, Human	9
PTN6_HUMAN	P29350	CHEMBL3166	Protein-tyrosine Phosphatase 1C, Human	26

Regulation of IFNG signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
PTN11_HUMAN	Q06124	CHEMBL3864	Protein-tyrosine Phosphatase 2C, Human	9
PTN6_HUMAN	P29350	CHEMBL3166	Protein-tyrosine Phosphatase 1C, Human	26

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PTN1_MOUSE	P35821	CHEMBL3336	Protein-tyrosine Phosphatase 1B, Mouse	3	0	0	2
PTN1_RAT	P20417	CHEMBL2371	Protein-tyrosine Phosphatase 1B, Rat	11	0	0	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PTN11_HUMAN	Q06124	CHEMBL3864	Protein-tyrosine Phosphatase 2C, Human	45	6	4	2
PTN12_HUMAN	Q05209	CHEMBL3236	Protein-tyrosine Phosphatase G1, Human	2	0	0	0
PTN13_HUMAN	Q12923	CHEMBL2976	Protein-tyrosine Phosphatase 1E, Human	5	1	0	0
PTN22_HUMAN	Q9Y2R2	CHEMBL2889	Hematopoietic Cell Protein-tyrosine Phosphatase 70Z-PEP, Human	60	10	0	0
PTN2_HUMAN	P17706	CHEMBL3807	T-cell Protein-tyrosine Phosphatase, Human	430	8	4	7
PTN6_HUMAN	P29350	CHEMBL3166	Protein-tyrosine Phosphatase 1C, Human	27	0	0	0
PTN7_HUMAN	P35236	CHEMBL2219	Protein-tyrosine Phosphatase LC-PTP, Human	49	4	0	0

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
PTN1-1-E	Protein-tyrosine Phosphatase 1B (cluster #1 Of 4), Eukaryotic	1,336	21	17	22
PTN1-2-E	Protein-tyrosine Phosphatase 1B (cluster #2 Of 4), Eukaryotic	136	2	0	3
PTN1-3-E	Protein-tyrosine Phosphatase 1B (cluster #3 Of 4), Eukaryotic	79	7	7	2
PTN1-4-E	Protein-tyrosine Phosphatase 1B (cluster #4 Of 4), Eukaryotic	16	1	1	0

Uniprot	Swissprot	Chembl	Description	Number Shared
PTN2_HUMAN	P17706	CHEMBL3807	T-cell Protein-tyrosine Phosphatase, Human	425
PTPRF_HUMAN	P10586	CHEMBL3521	Receptor-type Tyrosine-protein Phosphatase F (LAR), Human	64
MPIP2_HUMAN	P30305	CHEMBL4804	Dual Specificity Phosphatase Cdc25B, Human	44
PTPRA_HUMAN	P18433	CHEMBL3918	Receptor-type Tyrosine-protein Phosphatase Alpha, Human	30
PTN6_HUMAN	P29350	CHEMBL3166	Protein-tyrosine Phosphatase 1C, Human	26
PTPRC_HUMAN	P08575	CHEMBL3243	Leukocyte Common Antigen, Human	25
PPAC_HUMAN	P24666	CHEMBL4903	Low Molecular Weight Phosphotyrosine Protein Phosphatase, Human	15
DUS3_HUMAN	P51452	CHEMBL2635	Dual Specificity Protein Phosphatase 3, Human	14
MPIP1_HUMAN	P30304	CHEMBL3775	Dual Specificity Phosphatase Cdc25A, Human	13
PPM1B_HUMAN	O75688	CHEMBL2845	Protein Phosphatase 2C Beta, Human	13
Q8AWE3_CHICK	Q8AWE3	CHEMBL2669	Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick	13
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	10
PTN11_HUMAN	Q06124	CHEMBL3864	Protein-tyrosine Phosphatase 2C, Human	9
PTN7_HUMAN	P35236	CHEMBL2219	Protein-tyrosine Phosphatase LC-PTP, Human	9
PTN22_HUMAN	Q9Y2R2	CHEMBL2889	Hematopoietic Cell Protein-tyrosine Phosphatase 70Z-PEP, Human	8
PTPRB_HUMAN	P23467	CHEMBL2706	Receptor-type Tyrosine-protein Phosphatase Beta, Human	8
DUS1_HUMAN	P28562	CHEMBL6026	Dual Specificity Protein Phosphatase 1, Human	5
Q7ARH8_YERPE	Q7ARH8	CHEMBL3643	Secreted Protein-tyrosine Phosphatase, Yerpe	5
YOPH_YEREN	P15273	CHEMBL4404	Tyrosine-protein Phosphatase YopH, Yeren	3
DHI1_HUMAN	P28845	CHEMBL4235	11-beta-hydroxysteroid Dehydrogenase 1, Human	2
DPOLB_RAT	P06766	CHEMBL4343	DNA Polymerase Beta, Rat	2
PA2GA_HUMAN	P14555	CHEMBL3474	Phospholipase A2 Group IIA, Human	2
PP1A_HUMAN	P62136	CHEMBL2164	Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human	2
PTN12_HUMAN	Q05209	CHEMBL3236	Protein-tyrosine Phosphatase G1, Human	2
PTN1_MOUSE	P35821	CHEMBL3336	Protein-tyrosine Phosphatase 1B, Mouse	2
PTP1_YEAST	P25044	CHEMBL4452	Protein-tyrosine Phosphatase 1, Yeast	2
PTPA_MYCTU	P65716	CHEMBL4542	Probable Low Molecular Weight Protein-tyrosine-phosphatase, Myctu	2
PYGM_RABIT	P00489	CHEMBL4696	Glycogen Phosphorylase, Muscle Form, Rabit	2
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	1
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1
2ABG_HUMAN	Q9Y2T4	CHEMBL2507	Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human	1
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	1
CAH12_HUMAN	O43570	CHEMBL3242	Carbonic Anhydrase XII, Human	1
CAH14_HUMAN	Q9ULX7	CHEMBL3510	Carbonic Anhydrase XIV, Human	1
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	1
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	1
CAH3_HUMAN	P07451	CHEMBL2885	Carbonic Anhydrase III, Human	1
CAH5A_HUMAN	P35218	CHEMBL4789	Carbonic Anhydrase VA, Human	1
CAH5B_HUMAN	Q9Y2D0	CHEMBL3969	Carbonic Anhydrase VB, Human	1
CAH6_HUMAN	P23280	CHEMBL3025	Carbonic Anhydrase VI, Human	1
CAH7_HUMAN	P43166	CHEMBL2326	Carbonic Anhydrase VII, Human	1
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	1
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	1
DPOLB_HUMAN	P06746	CHEMBL2392	DNA Polymerase Beta, Human	1
EST1_HUMAN	P23141	CHEMBL2265	Acyl Coenzyme A:cholesterol Acyltransferase, Human	1
I23O1_HUMAN	P14902	CHEMBL4685	Indoleamine 2,3-dioxygenase, Human	1
IKKB_HUMAN	O14920	CHEMBL1991	Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human	1
LOX1_SOYBN	P08170	CHEMBL4586	Seed Lipoxygenase-1, Soybn	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
MPIP2_MOUSE	P30306	CHEMBL2723	Dual Specificity Phosphatase Cdc25B, Mouse	1
MPIP3_HUMAN	P30307	CHEMBL2378	Dual Specificity Phosphatase Cdc25C, Human	1
NANH_CLOPE	P10481	CHEMBL5189	Sialidase, Clope	1
O49150_SOLTU	O49150	CHEMBL3317	5-lipoxygenase, Soltu	1
PA21B_NAJME	P00599	CHEMBL3967	Phospholipase A2 Isozyme DE-I, Najme	1
PA2A_PROFL	P59264	CHEMBL5022	Phospholipase A2 Isozyme PLA-A, Profl	1
PA2GD_HUMAN	Q9UNK4	CHEMBL4281	Group IID Secretory Phospholipase A2, Human	1
PA2GE_HUMAN	Q9NZK7	CHEMBL2154	Group IIE Secretory Phospholipase A2, Human	1
PA2GF_HUMAN	Q9BZM2	CHEMBL4278	Group IIF Secretory Phospholipase A2, Human	1
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	1
PP2AA_MOUSE	P63330	CHEMBL2451	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse	1
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	1
PPAL_YEAST	P40347	CHEMBL5397	Low Molecular Weight Phosphotyrosine Protein Phosphatase, Yeast	1
PPM1J_MOUSE	Q149T7	CHEMBL2776	Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse	1
PTPA_HUMAN	Q15257	CHEMBL2505	Protein Phosphatase 2A Regulatory Subunit B', Human	1
Q4U254_9ENTO	Q4U254	CHEMBL2857	Human Rhinovirus A Protease, 9ento	1
Q7T3S7_ECHCA	Q7T3S7	CHEMBL4195	Phospholipase A2, Echca	1