UCSF

Protein-tyrosine Phosphatase 2C, Human (45 Compounds)

Swissprot:
PTN11_HUMAN
Stitch:
PTN11_HUMAN
UniProt:
Q06124
ChEMBL:
CHEMBL3864
Reactome:
REACT_25148
REACT_147727
REACT_19344
REACT_19405
REACT_17025
REACT_21247
REACT_12578
REACT_25162
REACT_23837
REACT_27307
REACT_111184
REACT_22384
REACT_19324
REACT_12519
REACT_21270
REACT_976
REACT_75829
REACT_23879
REACT_115697
REACT_25216
REACT_24980
REACT_23916
REACT_169118
REACT_111040
REACT_111080
REACT_12621
PDB:
2SHP (DOCK)
3B7O (DOCK)
3MOW (DOCK)
3O5X (DOCK)
3TKZ (DOCK)
3TL0 (DOCK)
PTPN11

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 45 6 4 2
Binding ≤ 1μM 5 2 0 0
Functional ≤ 10μM 0 0 0 0

Reactome Network (26)

Reactome ID Description Species
REACT_25148 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Homo sapiens
REACT_147727 Constitutive PI3K/AKT Signaling in Cancer Homo sapiens
REACT_19344 Costimulation by the CD28 family Homo sapiens
REACT_19405 CTLA4 inhibitory signaling Homo sapiens
REACT_17025 Downstream signal transduction Homo sapiens
REACT_21247 FRS2-mediated cascade Homo sapiens
REACT_12578 GAB1 signalosome Homo sapiens
REACT_25162 Interferon alpha/beta signaling Homo sapiens
REACT_23837 Interleukin-3, 5 and GM-CSF signaling Homo sapiens
REACT_27307 Interleukin-6 signaling Homo sapiens
REACT_111184 Negative regulation of FGFR signaling Homo sapiens
REACT_22384 Netrin mediated repulsion signals Homo sapiens
REACT_19324 PD-1 signaling Homo sapiens
REACT_12519 PECAM1 interactions Homo sapiens
REACT_21270 PI-3K cascade Homo sapiens
REACT_976 PI3K Cascade Homo sapiens
REACT_75829 PIP3 activates AKT signaling Homo sapiens
REACT_23879 Platelet sensitization by LDL Homo sapiens
REACT_115697 Prolactin receptor signaling Homo sapiens
REACT_25216 Regulation of IFNA signaling Homo sapiens
REACT_24980 Regulation of IFNG signaling Homo sapiens
REACT_23916 Signal regulatory protein (SIRP) family interactions Homo sapiens
REACT_169118 Signaling by Leptin Homo sapiens
REACT_111040 Signaling by SCF-KIT Homo sapiens
REACT_111080 Spry regulation of FGF signaling Homo sapiens
REACT_12621 Tie2 Signaling Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

Interferon alpha/beta signaling

Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

Interleukin-3, 5 and GM-CSF signaling

Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

PD-1 signaling

Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

PECAM1 interactions

Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

Platelet sensitization by LDL

Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

Regulation of IFNA signaling

Uniprot Swissprot Chembl Description Number Shared
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 9
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

Regulation of IFNG signaling

Uniprot Swissprot Chembl Description Number Shared
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 9
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1

Signal regulatory protein (SIRP) family interactions

Uniprot Swissprot Chembl Description Number Shared
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PTN12_HUMAN Q05209 CHEMBL3236 Protein-tyrosine Phosphatase G1, Human 2 0 0 0
PTN13_HUMAN Q12923 CHEMBL2976 Protein-tyrosine Phosphatase 1E, Human 5 1 0 0
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1,512 31 25 26
PTN22_HUMAN Q9Y2R2 CHEMBL2889 Hematopoietic Cell Protein-tyrosine Phosphatase 70Z-PEP, Human 60 10 0 0
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 430 8 4 7
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 27 0 0 0
PTN7_HUMAN P35236 CHEMBL2219 Protein-tyrosine Phosphatase LC-PTP, Human 49 4 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
PTN11-1-E Protein-tyrosine Phosphatase 2C (cluster #1 Of 3), Eukaryotic 37 3 2 1
PTN11-2-E Protein-tyrosine Phosphatase 2C (cluster #2 Of 3), Eukaryotic 2 2 2 1
PTN11-3-E Protein-tyrosine Phosphatase 2C (cluster #3 Of 3), Eukaryotic 7 2 0 0
Uniprot Swissprot Chembl Description Number Shared
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 9
NR0B2_HUMAN Q15466 CHEMBL5603 Nuclear Receptor Subfamily 0 Group B Member 2, Human 4
PTCA_HUMAN Q14761 CHEMBL4806 Protein Tyrosine Phosphatase Receptor Type C-associated Protein, Human 2
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 2
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 1
DHI1_MOUSE P50172 CHEMBL3910 11-beta-hydroxysteroid Dehydrogenase 1, Mouse 1
DHI1_RAT P16232 CHEMBL2391 11-beta-hydroxysteroid Dehydrogenase 1, Rat 1
DHI2_HUMAN P80365 CHEMBL3746 11-beta-hydroxysteroid Dehydrogenase 2, Human 1
DHI2_RAT P50233 CHEMBL2908 11-beta-hydroxysteroid Dehydrogenase 2, Rat 1
HSF1_HUMAN Q00613 CHEMBL5869 Heat Shock Factor Protein 1, Human 1
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 1
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 1
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 1
PTPRA_HUMAN P18433 CHEMBL3918 Receptor-type Tyrosine-protein Phosphatase Alpha, Human 1