UCSF

Protein-tyrosine Phosphatase 1C, Human (27 Compounds)

Swissprot:
PTN6_HUMAN
Stitch:
PTN6_HUMAN
UniProt:
P29350
ChEMBL:
CHEMBL3166
Reactome:
REACT_19344
REACT_111133
REACT_25162
REACT_25078
REACT_23891
REACT_23837
REACT_19324
REACT_12519
REACT_23879
REACT_25216
REACT_24980
REACT_111225
REACT_23916
PDB:
1FPR (DOCK)
1GWZ (DOCK)
1X6C (DOCK)
2B3O (DOCK)
2RMX (DOCK)
2YU7 (DOCK)
3PS5 (DOCK)
PTPN6

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 27 0 0 0
Binding ≤ 1μM 6 0 0 0

Reactome Network (13)

Reactome ID Description Species
REACT_19344 Costimulation by the CD28 family Homo sapiens
REACT_111133 Growth hormone receptor signaling Homo sapiens
REACT_25162 Interferon alpha/beta signaling Homo sapiens
REACT_25078 Interferon gamma signaling Homo sapiens
REACT_23891 Interleukin receptor SHC signaling Homo sapiens
REACT_23837 Interleukin-3, 5 and GM-CSF signaling Homo sapiens
REACT_19324 PD-1 signaling Homo sapiens
REACT_12519 PECAM1 interactions Homo sapiens
REACT_23879 Platelet sensitization by LDL Homo sapiens
REACT_25216 Regulation of IFNA signaling Homo sapiens
REACT_24980 Regulation of IFNG signaling Homo sapiens
REACT_111225 Regulation of KIT signaling Homo sapiens
REACT_23916 Signal regulatory protein (SIRP) family interactions Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1

Growth hormone receptor signaling

Uniprot Swissprot Chembl Description Number Shared
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 26

Interferon alpha/beta signaling

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1

Interleukin-3, 5 and GM-CSF signaling

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1

PD-1 signaling

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1

PECAM1 interactions

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1

Platelet sensitization by LDL

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1

Regulation of IFNA signaling

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 26

Regulation of IFNG signaling

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 26

Signal regulatory protein (SIRP) family interactions

Uniprot Swissprot Chembl Description Number Shared
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 45 6 4 2
PTN12_HUMAN Q05209 CHEMBL3236 Protein-tyrosine Phosphatase G1, Human 2 0 0 0
PTN13_HUMAN Q12923 CHEMBL2976 Protein-tyrosine Phosphatase 1E, Human 5 1 0 0
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1,512 31 25 26
PTN22_HUMAN Q9Y2R2 CHEMBL2889 Hematopoietic Cell Protein-tyrosine Phosphatase 70Z-PEP, Human 60 10 0 0
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 430 8 4 7
PTN7_HUMAN P35236 CHEMBL2219 Protein-tyrosine Phosphatase LC-PTP, Human 49 4 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PTN6-1-E Protein-tyrosine Phosphatase 1C (cluster #1 Of 2), Eukaryotic 22 0 0 0
PTN6-2-E Protein-tyrosine Phosphatase 1C (cluster #2 Of 2), Eukaryotic 5 0 0 0
Uniprot Swissprot Chembl Description Number Shared
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 26
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 14
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 6
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 5
PTN22_HUMAN Q9Y2R2 CHEMBL2889 Hematopoietic Cell Protein-tyrosine Phosphatase 70Z-PEP, Human 5
PTN7_HUMAN P35236 CHEMBL2219 Protein-tyrosine Phosphatase LC-PTP, Human 4
PTN12_HUMAN Q05209 CHEMBL3236 Protein-tyrosine Phosphatase G1, Human 2
PTPRB_HUMAN P23467 CHEMBL2706 Receptor-type Tyrosine-protein Phosphatase Beta, Human 2
PTPRF_HUMAN P10586 CHEMBL3521 Receptor-type Tyrosine-protein Phosphatase F (LAR), Human 2
DUS3_HUMAN P51452 CHEMBL2635 Dual Specificity Protein Phosphatase 3, Human 1
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 1
PTP1_YEAST P25044 CHEMBL4452 Protein-tyrosine Phosphatase 1, Yeast 1