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ZINC 12

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Names
Compounds (21)
Reactome (16)
Related By:
Pathway (4)
Organism (0)
Gene (0)
Org. Clust. (0)
ChEMBL (12)
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Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human (21 Compounds)

Swissprot:: 2A5A_HUMAN
Stitch:: 2A5A_HUMAN
UniProt:: Q15172
ChEMBL:: CHEMBL4763
Reactome:: REACT_228196; REACT_228285; REACT_11065; REACT_19405; REACT_11063; REACT_200610; REACT_228314; REACT_682; REACT_23879; REACT_150425; REACT_228159; REACT_228251; REACT_228137; REACT_150471; REACT_228261; REACT_228060
PDB:: PPP2R5A

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	21	9	1	1
Binding ≤ 1μM	1	1	1	1

Reactome ID	Description	Species
REACT_228196	APC truncation mutants have impaired AXIN binding	Homo sapiens
REACT_228285	AXIN missense mutants destabilize the destruction complex	Homo sapiens
REACT_11065	Beta-catenin phosphorylation cascade	Homo sapiens
REACT_19405	CTLA4 inhibitory signaling	Homo sapiens
REACT_11063	Degradation of beta-catenin by the destruction complex	Homo sapiens
REACT_200610	disassembly of the destruction complex and recruitment of AXIN to the membrane	Homo sapiens
REACT_228314	misspliced GSK3beta mutants stabilize beta-catenin	Homo sapiens
REACT_682	Mitotic Prometaphase	Homo sapiens
REACT_23879	Platelet sensitization by LDL	Homo sapiens
REACT_150425	Resolution of Sister Chromatid Cohesion	Homo sapiens
REACT_228159	S33 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_228251	S37 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_228137	S45 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_150471	Separation of Sister Chromatids	Homo sapiens
REACT_228261	T41 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_228060	truncations of AMER1 destabilize the destruction complex	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

AXIN missense mutants destabilize the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Beta-catenin phosphorylation cascade

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

CTLA4 inhibitory signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Degradation of beta-catenin by the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

disassembly of the destruction complex and recruitment of AXIN to the membrane

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

misspliced GSK3beta mutants stabilize beta-catenin

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Mitotic Prometaphase

Uniprot	Swissprot	Chembl	Description	Number Shared
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Platelet sensitization by LDL

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Resolution of Sister Chromatid Cohesion

Uniprot	Swissprot	Chembl	Description	Number Shared
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

S33 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

S37 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

S45 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Separation of Sister Chromatids

Uniprot	Swissprot	Chembl	Description	Number Shared
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

T41 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

truncations of AMER1 destabilize the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
2ABG_HUMAN	Q9Y2T4	CHEMBL2507	Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human	21
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21
PTPA_HUMAN	Q15257	CHEMBL2505	Protein Phosphatase 2A Regulatory Subunit B', Human	21
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1
PP1A_HUMAN	P62136	CHEMBL2164	Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human	1
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AA_MOUSE	P63330	CHEMBL2451	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse	1
PPM1B_HUMAN	O75688	CHEMBL2845	Protein Phosphatase 2C Beta, Human	1
PPM1J_MOUSE	Q149T7	CHEMBL2776	Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse	1
PTN1_HUMAN	P18031	CHEMBL335	Protein-tyrosine Phosphatase 1B, Human	1
Q8AWE3_CHICK	Q8AWE3	CHEMBL2669	Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick	1

Synonyms
Compounds (21)
Related By:
Pathway (4)
Organism (0)
Gene (0)
ChEMBL (12)
Org. Clust. (0)
Rings (0)